Extract of palm fruit creeping (Serenoa repens) has antiproliferative antiandrogenic, anti-inflammatory, and anti-edematous effects, which are selectively manifested at the level of the prostate gland.In this case, the drug does not affect the level of sex hormones in the blood plasma, does not affect the potency and libido and does not change the level of prostate-specific antigen in the blood plasma.
Local antiproliferative effect of the drug is decreased activity of growth factors (especially the epidermal and fibroblastic), inhibition of binding of prolactin receptors and subsequent signal transduction processes violation in prostate cells and accelerate the apoptosis of prostate cells, which is reflected in the inhibition of growth of the prostate gland.
Mechanism topical antiandrogenic action due to inhibition of the synthesis of DHT from testosterone (by inhibiting the enzyme 5-alpha reductase type I and II) and its fixation to the cytosolic receptor of prostate cells, which prevents the penetration of the hormone to the nucleus. As a result, protein synthesis is reduced.
The mechanism of local anti-inflammatory effect is due to the fact that the fruit extract creeping palm (Serenoa repens) inhibits the activity of phospholipase A2, 5-lipoxygenase and the release of arachidonic acid, thereby reducing the synthesis of prostaglandins and leukotrienes which are mediators of inflammation. Prostamol® Uno reduces capillary permeability and vascular stasis, reduces swelling and inflammation in the prostate, eliminates the compression of the neck of the bladder and urinary canal, improving urodynamics.
Thus, the drug Prostamol® Uno contributes, on the one hand, to a decrease in the severity of the pathological symptoms of benign prostatic hyperplasia (dysuria, pollakiuria, nocturia, painful sensations and feelings of stress during urination, incomplete emptying of the bladder), increased volume and strength of urination. On the other hand, against the background of the use of the drug, further growth and increase in the volume of the prostate gland is slowed down.