PROTOLOR® Protargol (Prostolor protargol)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceSilver ProteinSilver Protein
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    • Dosage form: & nbsptablets for solution for topical use
    Composition:

    Composition per 1 tablet:

    Active substance:

    Silver Proteinate (Protargol) 200.0 mg

    Excipients:

    Povidone K-17 20.0 mg.

    Description:

    Round flat cylindrical tablets of yellow-brown or brown color, with a facet on both sides and risk from one side. Color heterogeneity is allowed.

    Pharmacotherapeutic group:Antiseptic
    ATX: & nbsp

    R.02.A.A   Antiseptics

    D.08.A.X   Other antiseptics and disinfectants

    D.08.A   Antiseptics and disinfectants

    D.08   Antiseptics and disinfectants

    Pharmacodynamics:

    Upon ingestion, silver proteinate dissociates with the formation of silver ions, which have an astringent, antiseptic and anti-inflammatory effect. Violating the replication of bacterial DNA, silver ions have a bacteriostatic effect. The mechanism of action of PROTOLOR 'Protargol is based on the fact that silver ions on the damaged mucous membrane precipitate proteins and form a protective film,which helps reduce the sensitivity of nerve endings and narrowing of blood vessels (this leads to a reduction in edema), which in turn causes the inhibition of inflammatory reactions.

    Silver ions also inhibit the multiplication of various bacteria. It is active against gram-positive and gram-negative microorganisms: Bacillus cereus, Candida albicans, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Aspergillus brasiliensis, Salmonella enterica subsp. enterica serovar abony.

    Pharmacokinetics:

    The preparation PROTOLOR® protargol with local application is practically not absorbed, the concentration in the plasma is extremely small, systemic effects and cases of silver poisoning in clinical practice have not been revealed.

    Indications:Symptomatic therapy of acute nasopharyngitis (rhinitis), sinusitis.
    Contraindications:

    - Hypersensitivity to the components of the drug;

    - Pregnancy;

    - The period of breastfeeding;

    - Atrophic rhinitis.

    Pregnancy and lactation:

    PROTOLOR® protectorol is contraindicated in pregnancy, as well as during lactation. Breastfeeding should be discontinued if necessary to use the drug.

    Dosing and Administration:

    Apply the solution topically.

    To prepare a 2% solution, 1 tablet (200 mg) is dissolved in 10 ml of the supplied solvent.

    After dilution, store the solution at a temperature of 2 to 8 ° C for no more than 30 days.

    Shake before use.

    In children under 6 years old, and also older than 6 years and adults, use a 2% solution of PROTOLOR® Protargol, dropping, respectively, 1-2 or 3-5 drops of the solution 2-3 times a day, respectively, into each nostril.

    Side effects:

    The incidence of adverse events following the use of the drug is classified according to WHO recommendations: very frequent -> 10%; frequent -> 1% and <10%; infrequent -> 0.1% and <1%; rare -> 0.01% and <0.1%; very rare - <0.01%; unknown frequency - based on available data, the frequency can not be estimated.

    Immune system disorders: rare - allergic reactions (skin itching, urticaria), very rare - anaphylactic shock, Quincke's edema, atopic dermatitis.

    General disorders and disorders at the site of administration: rare - irritation, burning sensation and numbness of the nasal mucosa.

    Other: rare - dry mouth, red eyes.

    In case of detection of undesirable reactions, including those not indicated in these instructions for use, discontinue use of the drug and consult a doctor.

    Overdose:

    Cases of an overdose have not been revealed.

    Interaction:

    Interactions with other drugs have not been identified.

    Special instructions:

    Before using the drug should consult with a specialist. Read the instructions for use carefully before using the product. Keep the manual, it may be needed again.

    The medicine you are treating is intended for you personally, and it should not be passed on to others, as it can harm them even if you have the same symptoms as you.

    Before application, it is necessary to clean the nasal passages.

    Do not exceed recommended doses, especially in children and the elderly.

    Do not use the drug for more than 7 days, unless the doctor has recommended a different duration of treatment. If symptoms persist after this time, you should consult your doctor.

    It is possible to stain the discharge from the nose in gray or blue.

    Effect on the ability to drive transp. cf. and fur:

    The drug does not affect the ability to drive vehicles and work with mechanisms that require rapidity of psychomotor reactions.

    Form release / dosage:

    Tablets for the preparation of a solution for topical application, 200 mg.

    Packaging:

    1 tablet in a planar cell packaging made of polyvinylchloride / polyvinylidene chloride film and aluminum foil printed lacquered.

    Solvent - "Water for Injection" in ampoules of low density polyethylene 10 ml.

    1 contour pack with the drug and 1 ampoule with a solvent, along with a bottle of dark glass, equipped with a lid-pipette and instructions for use in a pack of cardboard.

    Storage conditions:

    In the dark place at a temperature of no higher than 30 ° C.

    Keep out of the reach of children!

    Shelf life:

    2 years.

    Do not use after the expiry date printed on the package.

    Terms of leave from pharmacies:Without recipe
    Registration number:LP-004798
    Date of registration:13.04.2018
    Expiration Date:13.04.2023
    The owner of the registration certificate:BRIGHTFARM, LLCBRIGHTFARM, LLC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp15.05.2018
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