Silver proteinate - instructions for use, dose, side effects, contraindications

Has antimicrobial, astringent, cauterizing properties. During dissociation, silver ions cause the precipitation of proteins and cause bactericidal action. Interacts with tissue proteins, which leads to the formation of silver albumin. Then metal silver is recovered from the albumin, which interacts with the active groups of the enzymes, blocks them, thereby disrupting the metabolic processes in the microbial cell. At small concentrations of silver ions, only the precipitation of interstitial proteins occurs and astringent and anti-inflammatory effects occur. In high concentrations, silver ions cause damage to cell membranes and intracellular structures, providing a cauterizing effect (friable albumins are formed).

Pharmacokinetics:

Not studied.

Indications:

Gonorrheal chronic urethritis; conjunctivitis, blepharitis, blenorrhea; external otitis, acute and chronic rhinitis, hypertrophic pharyngitis.

ICD-10

XIV.N30-N39.N37.0 * Urethritis in diseases classified elsewhere

XIV.N30-N39.N34.2 Other urethritis

I.A50-A64.A54.9 Gonococcal infection, unspecified

I.A50-A64.A54.8 Other gonococcal infections

I.A50-A64.A54.6 Gonococcal infection of the anorectal region

I.A50-A64.A54.5 Gonococcal pharyngitis

I.A50-A64.A54.4 Gonococcal infection of the musculoskeletal system

I.A50-A64.A54.3 Gonococcal infection of the eye

I.A50-A64.A54.1 Gonococcal infection of the lower parts of the genito-urinary tract with abscessing of the periurethral and accessory glands

I.A50-A64.A54 Gonococcal infection

VIII.H60-H62.H62.4 * Otitis externa in other diseases classified elsewhere

VIII.H60-H62.H62.3 * External otitis in other infectious and parasitic diseases classified elsewhere

VIII.H60-H62.H62.1 * Otitis externa in viral diseases classified elsewhere

VIII.H60-H62.H62.0 * Otitis externa in bacterial diseases classified elsewhere

Contraindications:

Hypersensitivity, pregnancy, lactation.

Carefully:

Children up to 14 years.

Pregnancy and lactation:

The category of FDA recommendations is not defined.

Application during pregnancy and breastfeeding is contraindicated.

Dosing and Administration:

Locally. To lubricate the mucous membranes of the upper respiratory tract 1-5% solution is used, for washing the urethra and bladder - 1-3% solution, for washing the eyes - 1-3% solution.

For introduction into the external auditory meatus (with external otitis) or in each half of the nose (with rhinitis) 5 drops 3-5% solution 2 times a day.

Side effects:

Slight irritation of the mucous membrane, burning, itching.

Overdose:

Slight irritation of the mucous membrane, burning, itching.

Interaction:

Incompatible with zinc sulfate in combination Diphenhydramine + naphazoline + zinc sulfate, boric acid + zinc sulfate.

Special instructions:

In connection with the availability of more effective antibacterial agents, silver preparations of wide application do not currently have.

Instructions

Silver Protein (Argenti proteinas)