A single dose for immunization is 1 ml.
PRE-EXPOSURE IMMUNIZATION
Immunization according to the scheme: 1 ml of the immunizing dose at 0, 7 and 21 or 28 days. REVAKCINATION
- Persons with a constant risk of infection are advised to monitor the level of specific antibodies in the blood every 6 months.
- People with a frequent risk of infection are advised to check their antibody levels every two years.
In the case of a decrease in the level of antibodies in the blood below 0.5 IU / ml, one single booster dose is given by one immunizing dose.
It is necessary to take into account the fact that immunization with the Rabipur® vaccine provides a pronounced immune response and a protective level of specific antibodies that circulate for a long time.
In cases where the serological response is not possible, the first revaccination is recommended one year after the immunization course. Subsequent revaccinations are performed once every five years with a single immunizing dose.
POSTEXPOSITION VACCINATION
Begin the vaccination as soon as possible.
| For indications for use, see Table 1. Table 1. Relevant post-exposure immunization schedules, depending on contact categories. | Contact category | Nature of contact (Contact with an animal in whom rabies is suspected or suspected to be a disease, contact at an autopsy) | Vaccination schedule | | I | - Touching or feeding animals in the absence of mucus membranes and mucous membranes. Patient's skin without damage before and after contact. | Vaccination is not required. In case of doubt, vaccination is recommended according to the scheme: 1.0 ml of Rabipur ® at 0, 3, 7, 14, 30 and 90 days. | | II | Inflammation of intact skin; abrasions, scratches, superficial necrotic bites of the trunk, upper and lower extremities (except bites of dangerous localization: head, face, neck, hand, fingers and feet) caused by domestic and farm animals. | In the case of a bite, an immediate treatment is given to a domestic animal or a known animal according to the scheme: 1.0 ml of Rabipur ® at 0, 3, 7.14, 30 and 90 days). In the case of a bite, an unknown or suspicious rabies animal is assigned immediate combined treatment (active and passive immunization) according to the pattern: rabies immunoglobulin at day 0 and Rabipur® 1.0 ml at 0.37.14.30 and 90 days. If the observed pet remains healthy for 10 days, the treatment is discontinued. In other cases, treatment should continue. If laboratory evidence of the absence of rabies in an animal, the treatment is precautionary. | | III | -Any oblivion of the mucous membranes, any bites of the head, face, neck, hand, fingers and toes, genitals; single or multiple deep, bleeding laceration wounds inflicted by domestic or farm animals.-Any oblivion and damage caused by wild carnivorous cattle, bats and rodents. | Immediate combination treatment (active and passive immunization) according to the scheme: rabies immunoglobulin on day 0 and Rabipur® 1.0 ml at 0.37.14.30 and 90 days. If the observed pet remains healthy for 10 days, the treatment is discontinued. In other cases, treatment should continue. If the absence of rabies in an animal is proven in laboratory, the treatment is stopped. | |
* The patient should be warned that the immunization is not completed. In the event of subsequent contact with a rabid suspected rabies, a full vaccination course is necessary.
If it is necessary to carry out a combined course of anti-rabies treatment, an antirabies immunoglobulin is first introduced and, no more than 30 minutes later, the Rabipur® vaccine is administered after it. Heterologous anti-rabies immunoglobulin is prescribed in a dose of 40 ME for 1 kg of body weight, and homologous rabies immunoglobulin - in a dose of 20 ME per 1 kg of body weight. Do not exceed or decrease the dose, nor do you re-enter it due to the danger of reducing the effectiveness of vaccination.If the rabies immunoglobulin is unavailable at the time of the first injection, it should be administered no later than 3 days after the bite for immunoglobulin of rabies from the horse's serum (heterologous), and no later than 7 days after the bite for the rabies immunoglobulin from human serum homologous).
Persons who have been fully immunized.
In order to address the issue of the tactics of providing anti-rabies care to persons who have an indication in the history of a complete course of anti-rabies vaccination, it is recommended that the level of anti-rabies antibodies in the blood be determined. The protective level of antibodies is 0.5 IU / ml.
Depending on the timing of the course of anti-rabies vaccination, the regimens listed in Table 2 should be followed. Persons with immuno-deficient conditions.
| Table 2. Schemes of vaccination of persons previously immunized after bite. | Interval after the course of vaccination | Vaccination schedule | | Less than 1 year (subject to receiving a full course of immunization) | Vaccination in 0,3,7 days to 1,0 ml of Rabipur® | | More than 1 year | Full immunization according to the scheme of post-exposure prophylaxis (in accordance with the type of injury). | |
Persons with immuno-deficient conditions.
Persons with immunodeficient conditions receiving post-exposure anti-rabies treatment, it is recommended to monitor the protective level of antibodies in the blood 14 days after the end of the vaccination course. Depending on the level detected, sKeepantibodies, additional vaccine administration may be necessary. If the antibody level is lower than the protective level (0.5 IU / ml), an additional three-fold administration of the vaccine is necessary according to the scheme of 0.7, 21 or 28 days.
Sposabout the application.
The Rabipur vaccine can be used to vaccinate all age groups.
Restored vaccine: a clear or slightly opalescent liquid, colorless or light yellow in color.
The lyophilizate must be dissolved in the water for injection supplied in the package, just before use. Before administration, the solution should be shaken gently. The dissolved vaccine is not subject to storage and should be used immediately after the preparation of the solution.
Rabipur® must be injected intramuscularly into the deltoid muscle, or into the anterior lateral surface of the thigh in young children (up to 18 months).
You can not inject the vaccine into the gluteus muscle.