Hartman's solution - instructions for use, doses, side effects, contraindications

Excipients: hydrochloric acid - to pH 5.5-6.3, water for injection - up to 1000 ml, which corresponds to: sodium (Na⁺) - 131.0 mmol / l, potassium (K⁺) - 5.0 mmol / l, calcium (Ca²⁺) - 2.0 mmol / l, chloride (Cl^-) - 112.0 mmol / l, lactate - 28.0 mmol / l.

Theoretical osmolarity: 278 mOsm / l

Description:

A clear, colorless solution.

Pharmacotherapeutic group:electrolyte balance recovery agent

ATX: & nbsp

B.05.B.B.01 Electrolytes

Pharmacodynamics:

Hartmann's solution for composition and osmolarity corresponds to extracellular fluid. Therefore, it is used to compensate extracellular fluid and electrolytes, as well as to regulate the acid-base balance.Theoretically, Hartmann's solution is better than an isotonic infusion solution of sodium chloride, because it provides compensation for three important cations (Na⁺, K⁺ and Ca²⁺) in the extracellular fluid. Lactate is metabolized in the body to bicarbonate, so the solution has an alkalizing effect.

Pharmacokinetics:There is no information.

Indications:

Hypovolemia and pronounced dehydration with normal acid-base state or weak acidosis, incl. with the aim of compensating for water and electrolyte deficiencies due to severe vomiting and diarrhea, extensive burns, peritonitis, severe infection;

Maintaining the volume of extracellular fluid during and after surgery, which makes it possible to temporarily delay blood transfusion;

The initial stage of treatment of significant blood loss, shock, trauma.

Contraindications:

Hypersensitivity, hypervolemia, hypertonic dehydration, hyperkalemia, hypernatremia, arterial hypertension, cardiac and / or renal insufficiency, hyperchloremia, alkalosis, hepatic insufficiency (decrease in the formation of bicarbonate from lactate), hyperlactacidemia.

Carefully:Respiratory failure, acute dehydration, hypoproteinemia, simultaneous treatment with glucocorticosteroids and corticotropin.

Pregnancy and lactation:

During pregnancy, apply in cases where the expected benefit to the mother exceeds the possible risk to the fetus.

It should refrain from breastfeeding during the period of use of the drug because of the lack of relevant clinical data.

Dosing and Administration:

The total amount assigned depends on the clinical condition of the patient.

It is used up to 2500 ml per day in the form of intravenous infusion, with an average speed of 60 drops / minute, that is, 2.5 ml / kg of body weight / hour, with urgent conditions, the infusion rate can be increased to 100 drops / minute.

The average daily intake for adults - 1 liter, for children - 20-30 ml / kg.

During the first 24 hours, it is necessary to provide a daily fluid demand, plus half the deficit, and for the next 2 days - by a percentage of the fluid deficit. Thus, the total fluid deficit is compensated within 72 hours. When recovering a previously lost liquid, it is necessary to take into account the loss that continues and to reimburse it.

Side effects:

Hypervolaemia, hyperhydration, hyperchloremia; thrombophlebitis; anxiety; allergic reactions.

Overdose:There is no information.

Interaction:

It is possible to increase sodium retention in the body while taking the following medicines at the same time: nonsteroidal anti-inflammatory drugs, androgens, anabolic hormones, estrogens, corticotropin, mineralocorticoids, vasodilators, ganglion blockers.

When taking with potassium-sparing diuretics, inhibitors of angiotensin-converting enzyme and potassium preparations, the risk of hyperkalemia increases.

In combination with cardiac glycosides, the likelihood of their toxic effects increases.

It alkalinizes the urine and inhibits the elimination of drugs that have an alkaline reaction.

Accelerates the selection Li+ and salicylates.

Special instructions:

It is used to maintain the volume of plasma in physiological limits in urgent conditions.

Do not use if there is a pronounced deficit Na⁺, K⁺, Ca²⁺.

When used in a large volume, the acid-base state should be monitored.

In case of an overdose it is usually enough to stop the injection.

With renal failure, hemodialysis can be used with continuous monitoring of the acid-base state.

You can use only undamaged bottles, with a clear solution!

Effect on the ability to drive transp. cf. and fur:There is no information.

Form release / dosage:

Solution for infusion.

Packaging:500 ml of solution in a bottle (of low-density polyethylene) with a built-in holder for the dropper, marked with a scale, closed with a lid of rubber and plastic, with a ring-controlled first opening.

10 bottles together with instructions for use in a carton box (packaging for hospitals).

Storage conditions:

Store at a temperature of 15 to 25 ° C.

Keep out of the reach of children.

Shelf life:

3 years.

Do not use after the expiry date printed on the package.

Terms of leave from pharmacies:For hospitals

Registration number:П N014666 / 01

Date of registration:31.03.2008

Expiration Date:Unlimited

The owner of the registration certificate:Hemofarm ADHemofarm AD Serbia

Manufacturer: & nbsp

HEMOFARM, A.D. Serbia

Representation: & nbspHEMOFARM A.D. HEMOFARM A.D. Serbia

Information update date: & nbsp16.12.2016

Illustrated instructions

Instructions

Hartmann's solution (Hartman's solution)