Has antihypoxic effect. Normalizes the energy metabolism of cells, exposed to hypoxia or ischemia. Directly influencing on cardiomyocytes and neurons of the brain, optimizes their metabolism and functionjune. Cytoprotective effect is due to an increase in the energy potential, activation of the oxidative decarboxylation and rationalization of oxygen consumption (increased aerobic glycolysis and oxidation retardation fatty acids due to selective inhibition long-chain 3-ketoacyl-CoA thiolase).
Trimetazidine supports contractility, myocardium, prevents a decrease intracellular content of adenosine triphosphate (ATP) and creatine phosphate.
Under acidosis, it normalizes the functioning of ion channels of membranes, prevents the accumulation of calcium and sodium ions in cardiomyocytes, normalizes the intracellular concentration of potassium ions.
Reduces intracellular acidosis and increased phosphate content, due to myocardial ischemia and reperfusion. Prevents the damaging effect of free radicals, preserves the integrity of cell membranes, prevents the activation of neutrophils in the ischemic zone, prolongs the duration of the electrical potential, reduces the yield of creatine phosphokinase from cells and the severity of ischemic damage to the myocardium.
When angina pectoris reduces the frequency of attacks, reduces the need for nitrates, after 2 weeks of treatment increases exercise tolerance, sharp fluctuations in blood pressure decrease. Reduces dizziness and noise in the ears of ischemic etiology. In vascular pathology, the eye restores the functional activity of the retina.