Trimetazidine has antianginal, coronarodilating, antihypoxic and hypotensive effects.
Directly affecting the cardiomyocytes and neurons of the brain, it optimizes their metabolism and function. Cytoprotective effect is due to - increased energy potential and activation of oxidative decarboxylation rationalization oxygen consumption (increasing aerobic glycolysis and fatty acid oxidation blockade).
Supports contractility of the myocardium, prevents the reduction of intracellular (Content of adenosine triphosphate and phosphocreatinine, in conditions of acidosis normalizes the functioning of membrane ion channels, prevents accumulation of calcium and sodium in cardiomyocytes, normalizes the intracellular content of potassium ions, reduces intracellular acidosis and increased phosphate content due to myocardial ischemia and reperfusion .Prevents the damaging effect of free radicals, preserves the integrity of cell membranes, prevents the activation of neutrophils in the zone, ischemia, prolongs the duration of the electrical potential, reduces the yield of creatine phosphokinase from cells and the severity of myocardial ischemic damage.
When angina pectoris reduces the frequency of attacks (reduces the consumption of nitrates), after 2 weeks of treatment increases tolerance to physical exertion, blood pressure. Improves hearing and results of vestibular samples in patients with pathology of ENT organs, reduces dizziness and tinnitus. In vascular pathology, the eye restores the functional activity of the retina.