Intravenously slowly run for at least 3-5 minutes or drip for 20-30 minutes.
Doses of the drug and the duration of treatment is determined by the severity of the infectious process and the dynamics of clinical and bacteriological indicators.
Adults and children over 12 years with normal renal function
The recommended dose of the drug, which is prescribed every 8 hours, is 4.5 g (4 g piperacillin / 0.5 g tazobactam).
The total daily dose depends on the severity and localization of the infection and can vary from 2.25 g (2 g piperacillin / 0.25 g tazobactam) to 4.5 g (4 g piperacillin / 0.5 g tazobactam) drug administered every 6 or 8 hours
Children aged from 2 to 12 years.
For neutropenia:
In patients with normal kidney function and body weight less than 50 kg with a fever resulting from neutropenia, the dose is 90 mg (80 mg piperacillin / 10 mg tazobactam) per kilogram of body weight, which is injected every 6 hours in combination with the appropriate dose aminoglycoside.
In children with a body weight of more than 50 kg, the dose corresponds to an adult, and is administered in combination with aminoglycosides.
With intra-abdominal infection: In children with a body weight of up to 40 kg and normal renal function, the recommended dose is 112.5 mg / kg (100 mg piperacillin / 12.5 mg tazobactam) every 8 hours.
Children with a body weight of more than 40 kg and normal kidney function are given the same dose as an adult, i.e. 4.5 g of the preparation (4 g piperacillin / 0.5 g tazobactam) every 8 hours.
Treatment should be conducted for at least 5 days and not more than 14 days, given that the administration of the drug is continued for at least 48 hours after the disappearance of clinical signs of infection
Impaired renal function
Patients with chronic renal failure or a patient on hemodialysis, dose and frequency of administration should be adjusted to the degree of impaired renal function.
Recommended doses of the drug for adults and children (body weight> 50 kg) of adrenal insufficiency
Creatinine clearance (ml / min) | Recommended dosage of piperacillin / tazobactam |
>40 | Dose correction is not required |
20-40 | 12 g / 1.5 g / day (4 g / 0.5 g every 8 hours) |
<20 | 8 g / 1 g / day (4 g / 0.5 g every 12 h) |
For patients on hemodialysis, the maximum daily dose is 8 g / 1 g of piperacillin / tazobactam. In addition, since 30-50% piperacillin is withdrawn from the hemodialysis within 4 hours, one additional dose of 2 g / 0.25 g piperacillin / tazobactam should be given after each dialysis session.
Children 2-12 years with renal insufficiency:
The pharmacokinetics of piperacillin + [tazobactam] in children with renal insufficiency has not been studied. There are no data on doses with a combination of renal failure and neutropenia.
For children aged 2-12 years with renal insufficiency, it is recommended to adjust the dose as follows:
Recommended doses of the drug for children (body weight <50 kg) with renal failure
Creatinine clearance | The dose of piperacillin / tazobactam |
> 50ml / min | 112.5 mg / kg (100 mg, piperacillin / 12.5 mg tazobactam) every 8 hours |
<50 ml / min | 78.75 mg / kg (70 mg piperacillin / 8.75 mg tazobactam) every 8 hours |
Such a change in dose is only indicative. Each patient should be monitored for the timely detection of signs of an overdose. It is necessary to adjust the dose of the drug and the interval between the administration of the next dose accordingly.
No dosage adjustment required with a violation of the liver.
In elderly patients, dose adjustment is necessary only if there is a violation of kidney function.
Method of solution preparation.
The preparation is dissolved in one of the following solvents in accordance with the indicated volumes.
Dosage / vial (piperacillin / tazobactam) | Required volume of solvent |
4.50 g (4 g / 500 mg) | 20 ml |
The vial is rotated in a circular motion until the content is completely dissolved (with constant rotation, usually during 5-10 min.). The prepared solution is a colorless or pale yellow liquid.
Solvents compatible with the preparation: 0,9% solution of sodium chloride; sterile water for injections; 5% solution of dextrose.
The prepared solution can then be diluted to the volume required for intravenous administration (for example, from 50 ml to 150 ml) by one of the following compatible solvents: 0,9% solution of sodium chloride; sterile water for injections (the maximum recommended volume - 50 ml); 5% solution of dextrose.