Supirocin-B - instructions for use, doses, side effects, contraindications

Active substanceBetamethasone + MupirocinBetamethasone + Mupirocin

Similar drugsTo uncover

Supirocin®-B

ointment externally

Glenmark Pharmaceuticals Co., Ltd. India

Dosage form: & nbspOintment for external use.

Composition:

In 100 g of ointment contains:

active substances: mupirocin 2 g, betamethasone dipropionate, equivalent to betamethasone 0.05 g;

Excipients: macrogol-400 (polyethylene glycol-400), macrogol-4000 (polyethylene glycol-4000).

Description:Homogeneous ointment of white color.

Pharmacotherapeutic group:glucocorticosteroid for topical use + antibiotic

ATX: & nbsp

D.07.C.C.01 Betamethasone in combination with antibiotics

Pharmacodynamics:

Combination drug for external use, the effect of which is due to its constituent components.

Mupirocin - antibiotic produced by a microorganism Pseudomonas fluorescens. Mupirocin Suppresses the synthesis of the bacterial cell protein by reversible binding with isoleucyl-transport RNA synthetase, which prevents the inclusion of isoleucine in the protein chains under construction. When used in minimal inhibitory concentrations mupirocin has bacteriostatic, and in higher concentrations - bactericidal action.

Due to a specific mechanism of action and a unique chemical structure, there is no cross-resistance with other antibiotics.

With the correct application of mupirocin, the risk of the emergence of resistant strains of microorganisms is small.

Betamethasone - Glucocorticosteroid for external use. Has anti-inflammatory local, anti-allergic, anti-edematous and antiproliferative effect. Has a stronger vasoconstrictive effect than other fluoride-derived glucocorticosteroids; systemic effects are expressed only slightly due to limited absorption through the skin. When exposed to the skin, the edge accumulation of neutrophils is prevented, which leads to a decrease in exudation, production of cytokines, inhibition of migration of macrophages, leading ultimately to a decrease in the processes of infiltration and granulation.

Pharmacokinetics:

Mupirocin practically does not penetrate through undamaged skin. In the case of adsorption through damaged skin, it is metabolized to a microbiologically inactive metabolite - monic acid - and quickly excreted by the kidneys.

Betamethasone dipropionate is a lipophilic substance and is easily absorbed through the stratum corneum without undergoing biotransformation.Absorption is increased when applied to the skin in the area of the folds of the body, to the skin with damaged epidermis or to the area of inflammation, with frequent application of the drug or after application to a significant surface of the skin. Absorption of betamethasone dipropionate through the skin in children occurs faster than in adults.

Indications:

It is used for the treatment of atopic dermatitis, diffuse neurodermatitis, contact dermatitis (simple and allergic), exfoliative dermatitis, urticaria, herpetiform dermatitis, seborrheic dermatitis, eczema, psoriasis complicated by secondary bacterial infections.

Contraindications:

Hypersensitivity; cutaneous manifestations of syphilis; lupus; bacterial, viral, fungal skin diseases; trophic ulcers of the lower leg, associated with varicose veins; skin cancer, nevus, atheroma, melanoma, hemangioma, xanthoma, sarcoma; rosacea, vulgar acne, postvaccinal skin reactions, pregnancy and breastfeeding, children under 12 years.

Carefully:

Macrogol (polyethylene glycol) can be absorbed through the wound surface or through other skin lesions and excreted by the kidneys.

Ointments based on macrogol can not be used on extensive surfaces in conditions accompanied by increased absorption of polyethylene glycol, and especially with moderate and severe renal failure.

For patients with diabetes mellitus, glaucoma, tuberculosis, cataracts, prolonged use of the ointment on large areas of the skin is not recommended.

With caution should be used for atrophy of subcutaneous tissue, especially in the elderly.

Pregnancy and lactation:

The drug is contraindicated for use in pregnancy and lactation (breastfeeding).

Dosing and Administration:

Recommended dosage: apply a thin layer of ointment on the affected area 2-3 times a day for 5-14 days. Apply only for treatment of affected areas, having a length of not more than 10 cm or an area of not more than 100 cm².

If there is no clinical response within 3-5 days, they should be re-examined.

Side effects:

Burning, itching, irritation, dry skin, folliculitis, hypertrichosis, acne vulgaris, hypopigmentation, perioral dermatitis, allergic, contact dermatitis, skin maceration, secondary infection, skin atrophy, sweating.

Overdose:

Symptoms: reversible oppression of the hypothalamic-pituitary-adrenal system, manifestations of Cushing's syndrome, hyperglycemia, glucosuria.

Treatment: symptomatic.

Interaction:

Interactions of the drug with other drugs have not been identified.

Special instructions:

Avoid getting ointments in the eyes, mucous membranes, as well as open wounds and burns.

As with other antibacterial substances, prolonged use of the ointment can lead to an excessive growth of organisms that are not susceptible to its action, including fungi.

Given the presence of a potent glucocorticosteroid in the composition of the drug, the drug must be used in the acute period of the disease, briefly, on a minor skin surface.

Do not use the drug on the face skin in connection with the possibility of the appearance of telangiectasias, perioral dermatitis.

On the skin in the axillary and inguinal area the drug should be used only in cases of extreme necessity.

Do not use the drug under an occlusive dressing, because this can lead to atrophy of the epidermis, the appearance of striae, the development of superinfection.

Form release / dosage:

Ointment for external use.

Packaging:

For 5 g and 15 g in aluminum tubes, internally lacquered with latex, having a nozzle with a closed end, with a lid having a point for piercing.

One tube together with the instruction for use is placed in a cardboard box.

Storage conditions:

At a temperature not exceeding 25 FROM. Do not freeze.

Keep out of the reach of children.

Shelf life:

2 years.

Do not use after expiry date.

Terms of leave from pharmacies:On prescription

Registration number:LSR-004419/09

Date of registration:04.06.2009

Expiration Date:Unlimited

The owner of the registration certificate:Glenmark Pharmaceuticals Co., Ltd.Glenmark Pharmaceuticals Co., Ltd. India

Manufacturer: & nbsp

GLENMARK PHARMACEUTICALS, Ltd. India

Representation: & nbspGLENMARK IMPEX LLCGLENMARK IMPEX LLCRussia

Information update date: & nbsp20.11.2015

Illustrated instructions

Instructions

Supirocin®-B (Supirocin®-B)