Terbifin® is generally well tolerated. Side effects are usually mild or moderate and are transient. Below are the undesirable phenomena that were observed during clinical trials or after the release of the drug on the market.
When assessing the incidence of side effects, the following grades are used: "very often" (V1/ 10), "often" (from V1 / 100 <1/10), "sometimes" (V1 / 1000 <1/100), "rarely" (V1 / 10000 <1/1000), "very rarely" (V1 / 10000), including isolated messages.
On the part of the hematopoiesis system: very rarely - neutropenia, agranulocytosis, thrombocytopenia, increased activity of "liver" transaminases, lymphopenia.
From the immune system: very rarely - anaphylactoid reactions (including angioedema), cutaneous and systemic lupus erythematosus.
From the nervous system: often - headache; Sometimes - the violation of taste, including their loss (usually the recovery occurs in the within a few weeks after discontinuation of treatment). There are separate reports of cases of long-term disturbances of taste sensations.In some cases, while taking the drug, a decrease in food intake was noted, which led to a significant reduction in weight.
From the side of the liver: rarely hepatobiliary dysfunction (mostly of the cholestatic nature), including very rare cases of severe hepatic insufficiency (some with fatal outcome or requiring liver transplantation).
From the gastrointestinal tract (GIT): very often - a feeling of overflow of the stomach, loss of appetite, dyspepsia, nausea. Slight abdominal pain, diarrhea.
From the skin and subcutaneous tissue: very often - not severe skin reactions (rashes, hives), very rarely - serious skin reactions (including Stevens-Johnson syndrome, toxic epidermal necrolysis); psoriasis-like rashes on the skin or exacerbation of psoriasis. Rarely f cases of hair loss have been noted, although the cause-and-effect relationship of this phenomenon with taking the drug has not been established.
In case of progressing skin rash, treatment. Terbifin® should be discontinued.
From the musculoskeletal system: very often - arthralgia, myalgia. Other: very rarely - a feeling of fatigue.