Most side effects are transient, transient in long-term treatment.
According to the World Health Organization (WHO), adverse reactions are classified according to their frequency of development as follows: very often (> 1/10), often (> 1/100, <1/10), infrequently (> 1/1000, < 1/100), rarely (> 1/10000, <1/1000) and very rarely (<1/10000); frequency is unknown - according to available data, it was not possible to establish the frequency of occurrence.
From the gastrointestinal tract:
Often: nausea, abdominal pain, indigestion, diarrhea, bloating, decreased appetite; frequency unknown: pancreatitis.
From the liver and biliary tract:
rarely: hepatic insufficiency, up to a lethal outcome, increased activity of "liver" transaminases; frequency unknown: hepatitis, jaundice, stasis of bile.
From the immune system.
rarely: cutaneous lupus erythematosus, systemic lupus erythematosus; frequency is unknown: anaphylactic reactions, serum sickness. Allergic reactions: very common: rash, hives;
rarely: anaphylactoid reactions, angioedema,
polymorphic erythema, Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome), acute generalized exentematous pustulosis;
frequency is unknown: photosensitivity, polymorphic photo dermatosis.
From the skin and subcutaneous tissues:
rarely: psoriasis-like rash or exacerbation of psoriasis, alopecia.
From the musculoskeletal and connective tissue: Often: arthralgia, myalgia; frequency unknown: rhabdomyolysis. |
On the part of the hematopoiesis system:
rarely: neutropenia, lymphopenia, agranulocytosis, thrombocytopenia, pancytopenia;
frequency unknown: anemia, increased activity of creatine phosphokinase in the blood. From the central and peripheral nervous system: often: headache; |
rarely: weakening of taste sensations, loss of taste sensations; rarely: dizziness, paresthesia, hypoesthesia; |
frequency is unknown: loss of smell, decreased sense of smell, anxiety, depression.
From the sense organs:
frequency unknown: ringing in the ears, hearing loss, gipakuziya.
From the side of the cardiovascular system, the frequency is unknown: vasculitis.
Other:
rarely: fatigue, fatigue;
frequency is unknown: pyrexia, malaise, weight loss,
influenza-like syndrome.