The incidence of side effects is classified according to the recommendations of the World Health Organization: very often - not less than 10%; often - not less than 1%,but less than 10%; infrequently - not less than 0,1%, but less than 1%; rarely - not less than 0.01%, but less than 0.1%; very rarely - less than 0.01%, including isolated cases.
From the digestive system: very often - a feeling of overflow of the stomach, a decrease in appetite, indigestion, nausea, abdominal pain, diarrhea; infrequent- or loss of taste sensations (recovery occurs within: a few weeks after discontinuation of treatment), an increase activity "hepatic" transaminases; rarely - cholestasis, jaundice, hepatitis; in some cases, long-term eating disorders, leading to a failure to eat and a significant decrease in body weight, liver failure.
From the side of the blood and lymphatic system: very rarely - neutropenia, thrombocytopenia, agranulocytosis, lymphopenia, single cases of pancytopenia.
From the skin: very rarely - psoriasis-like rash, exacerbation of psoriasis, acute generalized pustular exanthema. Allergic reactions: Often- -. rash, hives; very rarely - angioedema, malignant epidermal erythema (Stevens-Johnson syndrome), anaphylactoid reactions, toxic epidermal necrolysis (Lyell's syndrome).
From the musculoskeletal system: very often - arthralgia, myalgia.
From the central and peripheral nervous system: often headache; rarely - paresthesia, hyposthenia, dizziness; very rarely - depression, anxiety.
From the side of the hearing organ and labyrinthine disorders: very rarely - vertigo. Other: rarely - malaise, weakness; very rarely - - systemic lupus erythematosus, including cutaneous form.