Classification of the incidence of adverse events (WHO):
very often> 1/10
often from> 1/100 to <1/10
infrequently from> 1/1000 to <1/100
rarely from> 1/10000 to <1/1000
very rarely from <1/10000, including individual messages.
From the central and peripheral nervous system:
Often: dizziness;
Often: headache;
Infrequently: anxiety, confusion, drowsiness;
Rarely: euphoria, emotional instability, nightmares, cognitive disorders, hallucinations, amnesia; disorders of coordination of movements, convulsions, paresthesia, tremor, impaired concentration, epileptiform seizures, with prolonged use - the development of drug dependence;
Rarely: panic attacks, ringing in the ears;
From the cardiovascular system:
Rarely: tachycardia, palpitations, cardiovascular collapse, fainting,
orthostatic hypotension, cardiovascular failure;
Rarely: bradycardia, increased blood pressure;
From the respiratory system:
Rarely: shortness of breath, respiratory depression, pulmonary edema;
From the sense organs:
Rarely: decreased visual acuity, sometimes mydriasis, a taste disorder;
From the digestive system:
Often: nausea;
Often: vomiting, constipation or diarrhea, dryness of the oral mucosa;
Infrequently: dyspepsia, abdominal pain, bloating;
Rarely: difficulty in swallowing;
Rarely: increased activity of "liver" transaminases;
From the skin:
Often: sweating;
From the genitourinary system:
Infrequently: urinary retention, increased frequency of urination, menstrual irregularity, signs of menopause;
Rarely: dysuria;
From the musculoskeletal system:
Rarely: muscle weakness;
From the side of metabolism:
Infrequently: anorexia;
Rarely: decreased body weight;
Allergic reactions:
Rarely: allergic reactions (eg urticaria, pruritus, exanthema, bullous rash, angioedema) and anaphylaxis, which can cause azole dyes E122, E124 and E151.
Other: with prolonged use - drug dependence; with a sharp abolition - the "cancellation" syndrome.