Threonyl-glutamyl-lysyl-lysyl-arginyl-arginyl-glutamyl-threonyl-valyl-glutamyl-arginyl-glutamyl-lysyl-glutamate (Treonyl-glutamyl-lysyl-lysyl-glutamyl-arginyl-arginyl-glutamyl-treonyl-valyl-glutamyl-arginyl-glutamyl-lysyl-glutamate)

Pharmacodynamics Pharmacokinetics Indications Carefully Contraindications Dosing and Administration Side effects
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Clinical and pharmacological group: & nbsp

Other immunomodulators

Antiviral drugs (excluding HIV)

Included in the formulation
  • Gepon
    lyophilizate locally externally 
    IMMAPHARMA, LLC     Russia
  • Gepon
    lyophilizate locally externally 
    IMMAPHARMA, LLC     Russia
    • АТХ:

    L.03.A.X   Other immunostimulants

    Pharmacodynamics:

    Stimulation of the synthesis of α- and β-interferons, mobilization and activation of macrophages, suppression of the synthesis of inflammatory cytokines (IL-1, -6, -8 and TNF-α), stimulation of the synthesis of antibodies to various antigens (including HIV antigens and opportunistic pathogens infections), suppression of viral replication.

    Pharmacokinetics:

    Not studied.

    Indications:
    • Correction of weakened immunity in immunodeficient states.
    • Treatment of HIV infection.
    • Enhance immune defense against infections.
    • Treatment and prevention of opportunistic infections caused by bacteria, viruses or fungi.
    • Treatment and prevention of candidiasis of skin and mucous membranes (including due to antibiotic therapy).
    • Reduction of inflammation (redness, swelling, itching, burning, pain) of mucous membranes and skin, as well as dryness of mucous membranes.
    ICD-10

    I.B20-B24   Disease caused by the human immunodeficiency virus [HIV]

    I.B35-B49.B37.0   Candidiasis stomatitis

    I.B35-B49.B37.2   Candidiasis of skin and nails

    I.B35-B49.B37.3   Candidiasis of the vulva and vagina (N77.1 *)

    I.B35-B49.B37.4   Candidiasis of other urogenital localizations

    Contraindications:

    Hypersensitivity, children's age (up to twelve years), breast-feeding.

    Carefully:

    Pregnancy.

    Pregnancy and lactation:

    Adequate and well-controlled studies in humans and animals have not been conducted. Use with caution! There is no information on the penetration into breast milk. The use is contraindicated!

    Category of recommendations for FDA is not defined.

    Dosing and Administration:

    The drug is prescribed for adults and children over 12 years at a dose of 10 mg orally once a day, or 1-2 mg in the form of 0.02-0.04% solution for local treatment of mucous membranes and skin 1 time per day.

    Side effects:

    When applied according to the indications in the recommended doses, the side effect is not established.

    Overdose:

    No data.

    Interaction:

    Not described.

    Special instructions:

    The results of clinical trials show that activation of local immunity positively influences the course of erosive and ulcerative lesions of the gastroduodenal zone in elderly patients.The drug can be recommended both in the form of monotherapy, and in combination with amoxicillin, metronidazole and omeprazole.

    Activation local gut mucosal immunity is effective for the treatment of intestinal dysbiosis and irritable bowel syndrome, wherein the preparation can be recommended as a monotherapy (microclysters).

    Instructions
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