Active substanceThreonyl-glutamyl-lysyl-lysyl-arginyl-arginyl-glutamyl-threonyl-valyl-glutamyl-arginyl-glutamyl-lysyl-glutamateThreonyl-glutamyl-lysyl-lysyl-arginyl-arginyl-glutamyl-threonyl-valyl-glutamyl-arginyl-glutamyl-lysyl-glutmat
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  • Gepon
    lyophilizate locally externally 
    IMMAPHARMA, LLC     Russia
  • Gepon
    lyophilizate locally externally 
    IMMAPHARMA, LLC     Russia
  • Dosage form: & nbsp
    lyophilizate for solution preparation for local and external use
    Composition:
    Active substance:
    Threonyl-glutamyl-lysyl-lysyl-arginyl-arginyl-glutamyl-threonyl-valyl-glutamyl-arginyl-glutamyl-lysyl-glutamate (Gepon) 1 mg, 2 mg
    Description:Lyophilized powder is white, odorless.
    Pharmacotherapeutic group:Immunomodulating agent
    ATX: & nbsp

    L.03.A.X   Other immunostimulants

    Pharmacodynamics:
    Gepon has an immunomodulatory and antiviral effect:
    - causes the production of alpha and beta interferons;
    - mobilizes and activates macrophages;
    - Limits the production of pro-inflammatory cytokines (interleukins-1, 6, 8 and tumor necrosis factor);
    - stimulates the production of antibodies to various antigens of infectious nature;
    - increases the content of CD4+ T cells and NK cells;
    - increases the functional activity of neutrophils and CD8+ T cells, which are the key links in protecting the body from bacteria, viruses and fungi;
    - Suppresses the replication of viruses.
    Due to these pharmacological properties, Gepon increases the resistance of the organism to infections caused by viruses, bacteria and fungi. Gepon has an anti-inflammatory effect within 1-2 days after application.
    Pharmacokinetics:Pharmacokinetics of the drug has not been studied due to its peptide nature.
    Indications:As part of combination therapy: treatment of infections of the mucous membranes and skin caused by Candida fungi; reducing the intensity of inflammation (redness, swelling, itching, burning, pain) mucous membranes and skin, dry mucous membranes. Prophylaxis of candidiasis of mucous membranes and skin on the background of antibiotic therapy.
    Contraindications:Individual hypersensitivity to Gepon. Children under 12 years.
    Pregnancy and lactation:The application is only possible if the potential benefit to the mother exceeds the possible harm to the fetus. Gepon is not recommended for use during breastfeeding. If it is necessary to use the drug, breastfeeding should be discontinued.
    Dosing and Administration:
    Apply topically, externally.
    Before use, the drug is dissolved in water for injection (with external application of the drug, i.e.for skin treatment) or in a 0.9% solution of sodium chloride (with topical application of the drug, ie for the treatment of mucous membranes).
    Method of preparation before use:
    1. Remove the protective part of the aluminum cap from the rubber bottle stopper with the medicine. If the drug is in the ampoule, open the ampoule.
    2. Open the ampoule with solvent (water for injections). A 0.9% solution of sodium chloride can also be used as a solvent.
    3. Put the needle on a disposable syringe (5/10 ml volume - see Table 1)
    4. Draw a solvent into the syringe (the volume of the solvent is listed in Table 1).
    5. Puncture the needle with a syringe rubber plug of the vial with the drug and pour into the vial 2 - 2.5 ml of the solvent. If the drug is in the ampoule, pour into the opened ampoule also 2 -2.5 ml of the solvent.
    6. Without removing the needle, with light vibrational movements for about 1 minute, completely dissolve the contents of the vial (ampoule).
    7. Collect the resulting solution in a syringe with the rest of the solvent. The final volume of solution in the syringe should correspond to the volume indicated in Table 1.
    8. Remove the syringe with the needle from the vial (ampoule), lightly vibrating for about 1 minute, completely mix the solution in the syringe.
    9. Remove the needle from the syringe.
    10. Use as dosing syringe for installation devices, application to the skin and mucous membranes or wet gauze.

    Table 1


    Mode of application

    Gepon 0,02% solution

    Gepon 0,04% solution

    1

    2

    1

    2

    Water for injection, ml

    externally

    -

    -

    2,5

    5

    0.9% sodium chloride solution, ml

    locally

    5

    10

    -


    The recommended dose for adults and children 12 years and older is 1-2 mg in the form of 0.02% solution for local treatment of the mucous membranes once a day.
    The recommended dose for adults and children 12 years and older is 1-2 mg in the form of a 0.04% solution for skin treatment once a day.
    For the treatment of mucosal infections caused by fungi Candida, topical application Gepona recommended by applying to the affected area of ​​the mucous membranes (vulva, vagina, urethra) 0.02% solution in the course of 3 application (once a day) from day intervals 1-3 between applications.
    For the treatment of skin infections caused by fungi Candida, it recommended Gepona external use by applying to the affected skin of 0.04% solution in the course of application of 3 (once daily) intervals 1-3 days between applications.
    By vulvovaginitis, urethritis women apply processing solution 0.02% Gepona mucosa of vulva, vagina, as well as a lotion to the affected areas of the skin adjacent to the entrance to the vagina Gepona 0.04% solution.
    With urethritis and balanoposthitis, men use installations with 0.02% Gepon solution in the urethra and lotions on the affected skin areas with 0.04% Gepon solution.
    Treatment of the mucous membranes and skin is carried out by a course of 3 doses (once a day) at intervals of 1-3 days.
    Prevention of candidiasis of the mucous membranes on the background of antibiotic therapy: it is recommended to carry out lotions 0.02% Gepon solution during the course of antibiotic treatment. Treatment of the mucous membranes is carried out by a course of 3 doses (once a day) at intervals of 1-3 days.
    Prevention of skin kalidoza against antibiotic therapy: it is recommended to carry out lotions 0.04% solution of Gepon during the course of treatment with an antibiotic. Skin treatment is carried out in a course of 3 doses (once a day) at intervals of 1-3 days.
    To reduce the intensity of inflammation and dryness, the mucous membranes should be treated with 0.02% Gepon solution. Treatment of the mucous membranes is carried out by a course of 3 doses (once a day) at intervals of 1-3 days.
    To reduce the intensity of skin inflammation: apply gauze wipes moistened with 0.04% Gepon solution. Skin treatment is carried out in a course of 3 doses (once a day) at intervals of 1-3 days.
    Side effects:Not detected.Allergic reactions are possible. If any of the side effects listed in the manual are aggravated, or if you notice any other side effects not listed in the instructions, tell your doctor.
    Overdose:Symptoms of overdose are not described.
    Interaction:Not described.
    Effect on the ability to drive transp. cf. and fur:The drug does not affect the ability to drive vehicles, moving mechanisms and engage in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.
    Form release / dosage:
    Liofilizate for solution for local and external use, 1 mg, 2 mg.
    Packaging:
    For 1 mg, 2 mg of the drug in vials. For 1 mg, 2 mg of the drug in ampoules.
    1, 2, 3 vials or ampoules with instructions for use in the pack;
    1 vial or ampoule with the drug, 1 ampoule with water for injection 5 ml with instructions for use in the pack (Kit);
    1 vial or ampoule with the drug, 1 ampoule with water for injection 5 ml, 1 disposable sterile syringe with instructions for use in the pack (Kit);
    Storage conditions:Store in a dark place at a temperature of no higher than 25 ° C.Keep out of the reach of children.
    Shelf life:4 years. Do not use after expiry date.
    Terms of leave from pharmacies:Without recipe
    Registration number:LSR-001794/07
    Date of registration:30.07.2007 / 30.06.2014
    Expiration Date:Unlimited
    The owner of the registration certificate:IMMAPHARMA, LLC IMMAPHARMA, LLC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp02.04.2017
    Illustrated instructions
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