Active substanceThreonyl-glutamyl-lysyl-lysyl-arginyl-arginyl-glutamyl-threonyl-valyl-glutamyl-arginyl-glutamyl-lysyl-glutamateThreonyl-glutamyl-lysyl-lysyl-arginyl-arginyl-glutamyl-threonyl-valyl-glutamyl-arginyl-glutamyl-lysyl-glutmat
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  • Gepon
    lyophilizate locally externally 
    IMMAPHARMA, LLC     Russia
  • Gepon
    lyophilizate locally externally 
    IMMAPHARMA, LLC     Russia
  • Dosage form: & nbsp
    lyophilizate for solution preparation for local and external use
    Composition:
    Active substance:
    gepon 1; 2 mg.
    Description:Lyophilized powder is white, odorless.
    Pharmacotherapeutic group:Immunomodulating agent
    ATX: & nbsp

    L.03.A.X   Other immunostimulants

    Pharmacodynamics:
    Gepon has an immunomodulatory and antiviral effect:
    - causes the production of alpha and beta interferons;
    - mobilizes and activates macrophages;
    - Limits the production of pro-inflammatory cytokines (interleukins-1, 6, 8 and tumor necrosis factor);
    - stimulates the production of antibodies to various antigens of infectious nature;
    - Suppresses the replication of viruses.
    Due to these pharmacological properties, Gepon increases the resistance of the organism to infections caused by viruses, bacteria and fungi. Gepon has an anti-inflammatory effect within 1-2 days after application.
    In patients infected with HIV, Gepon reduces the concentration of HIV in blood cells and in plasma,simultaneously activates immune responses specific for HIV:
    - increases the content of CD4+ T cells and NK cells;
    - increases the functional activity of neutrophils and CD8+ T cells, which are the key links in protecting the body from bacteria, viruses and fungi;
    -increases the production of antibodies specific for HIV antigens, as well as antigens of pathogens of opportunistic infections that are relevant for this patient;
    - prevents relapses of opportunistic infections within 3-6 months.
    Pharmacokinetics:Pharmacokinetics of the drug has not been studied due to its peptide nature.
    Indications:
    - correction of weakened immunity in patients with immunodeficiency states;
    - Increase of immune protection against infections;
    - treatment of infections of mucous membranes and skin caused by Candida fungi;
    -prophylaxis of candidiasis of mucous membranes and skin, as a result of antibiotic therapy;
    -to reduce inflammation (redness, swelling, itching, burning, pain) mucous membranes and skin, as well as dryness of mucous membranes.
    Contraindications:Individual hypersensitivity to Gepon. Children under 12 years.
    Pregnancy and lactation:The use is only possible if the potential benefit to the pregnant woman exceeds the possible harm to the fetus. Gepon is not recommended for use by nursing mothers. If it is necessary to use the drug, breastfeeding should be discontinued.
    Dosing and Administration:
    Before use, the drug is dissolved in water or saline.
    Method of preparation before use:
    1. Remove the protective part of the aluminum cap from the rubber bottle stopper with the medicine. If the drug is in the ampoule, open the ampoule.
    2. Open the ampoule with solvent (water for injection or physiological saline).
    3. Put the needle on the disposable syringe.
    4. Draw into the syringe 5.0 ml of solvent.
    5. Puncture the rubber stopper of the vial with the drug with a syringe with a syringe and pour into the vial 2.0 - 2.5 ml of the solvent. If the drug is in the ampoule, add 2.0 - 2.5 ml of solvent to the opened ampoule.
    6. Without removing the needle, with light vibrational movements for about 1 minute, completely dissolve the contents of the vial (ampoule).
    7. Collect the resulting solution in a syringe, in which there were 2.5 - 3.0 ml of solvent.
    8.Wait 1 minute before completely mixing the solution in the syringe.
    9. Remove the needle from the syringe.
    10. Use a syringe as a metering device for instillation, irrigation or wetting of gauze wipes.
    The recommended dose for adults and children 12 years and older is 1-2 mg in the form of 0.02-0.04% solution for local treatment of mucous membranes and skin once a day.
    To treat infections of mucous membranes and skin caused by Candida fungi, local application of Gepon by irrigation of affected areas of mucous membranes and skin with 0,02-0,04% solution, a course of 3 irrigation with an interval of 1-3 days between irrigation is recommended.
    With vulvovaginitis, urethritis, cervicitis, women are treated with irrigation 0.02-0.04% with Gepon's solution of the vulvar mucosa, vagina, cervix, and also lotion on the affected skin areas adjacent to the entrance to the vagina.
    When urethritis and balanoposthitis in men apply instillation 0.02-0.04% solution of Gepon in the urethra and lotion on the affected skin. The treatment of mucous membranes and skin is repeated three times with an interval of 1 -3 days.
    For the prevention of candidiasis of the mucous membranes and skin as a possible complication in antibiotic therapy, it is recommended to perform irrigation (lotions) 0.02-0.04% solution of Gepon during the course of treatment with an antibiotic.
    To reduce the intensity of inflammation, the mucous membranes should be irrigated with 0.02-0.04% solution of Gepon, and gauze napkins moistened with 0.02-0.04% Gepon solution should be applied to the inflamed skin areas.
    Side effects:Not detected.
    Overdose:Symptoms of overdose are not described.
    Interaction:Not described.
    Effect on the ability to drive transp. cf. and fur:The drug does not affect the ability to drive vehicles, moving mechanisms and engage in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.
    Form release / dosage:
    Liofilizate for solution for local and external use, 1 mg, 2 mg.
    Packaging:
    For 1 mg, 2 mg of the drug in vials.
    For 1 mg, 2 mg of the drug in ampoules.
    1, 2, 3 vials or ampoules with instructions for use in the pack;
    1 vial or ampoule with the drug, 1 ampoule with water for injection 5 ml with instructions for use in the pack (Kit);
    1 vial or ampoule with the drug, 1 ampoule with water for injection 5 ml, 1 disposable sterile syringe with instructions for use in the pack (Kit);
    30 vials or ampoules 5-10 instructions for use in a pack (for hospitals).
    Storage conditions:Store in a dark place at a temperature of no higher than 25 ° C. Keep out of the reach of children.
    Shelf life:4 years. Do not use after expiry date.
    Terms of leave from pharmacies:Without recipe
    Registration number:P N000015 / 01
    Date of registration:01.09.2011 / 08.09.2014
    Expiration Date:Unlimited
    The owner of the registration certificate:IMMAPHARMA, LLC IMMAPHARMA, LLC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp02.04.2017
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