Trixymethacin (TROXIMETHACIN)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceIndomethacin + TroxerutinIndomethacin + Troxerutin
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  • Indovazin®
    gel externally 
    Balkanfarm - Troyan AD     Bulgaria
  • Trixymethacin
    gel externally 
    VetProm AD     Bulgaria
    • Dosage form: & nbspgel for external use
    Composition:

    1 g of the preparation contains:

    active substances: indomethacin 30 mg, troxerutin 20 mg;

    Excipients: carbomer 15 mg, disodium edetate 0.5 mg, sodium benzoate 2.5 mg, macrogol-400 522 mg, isopropanol 150 mg, dimethyl sulfoxide 150 mg, water purified 110 mg.

    Description:

    Homogeneous, transparent gel from yellow to yellow-brown color.

    Pharmacotherapeutic group:anti-inflammatory agent for topical application
    ATX: & nbsp

    M.01.A.B.51   Indomethacin in combination with other drugs

    Pharmacodynamics:

    Combination drug for topical administration, which includes indomethacin and troxerutin.

    Indomethacin has a pronounced anti-inflammatory, analgesic and anti-edematous effect, leading to pain relief, reduction of edema and a reduction in the recovery time of the affected tissues. The main mechanism of action is associated with the suppression of the synthesis of prostaglandins by reversible blockade of cyclooxygenase 1 and 2.

    Troxerutin (trihydroxyethylrutinoside) is a bioflavonoid. Provides angioprotective action.Reduces the permeability of capillaries and exhibits a venotonic effect. It blocks the venodilating effect of histamine, bradykinin and acetylcholine. It acts anti-inflammatory on perennial tissue, reduces the fragility of capillaries and has some anti-aggregative effect. Reduces puffiness, improves trophism with various pathological changes associated with venous insufficiency.

    Triximethacin gel when applied to the skin suppresses the inflammatory edematous reaction, reduces pain and temperature in the foci of inflammation, located on the surface and in the depth, reaching the blood vessels located there. Has pronounced venotonic, capillaroprotective action.

    Pharmacokinetics:

    The gel base used ensures the solubility and release of drug components Indomethacin and Troxerutin.

    Gel dosage form, which includes indomethacin and troxerutin, is well absorbed from the surface of the skin and provides a therapeutic effect of the drug.

    When applied to the skin in the subcutaneous tissue and periarticular tissues, concentrations close to therapeutic are created.The penetration of active components into the systemic circulation is clinically insignificant.
    Indications:

    For symptomatic treatment:

    - in the complex therapy of chronic venous insufficiency of the lower extremities (varicose veins) - to relieve swelling, feelings of heaviness and pain in the legs;

    - superficial thrombophlebitis, phlebitis; post-phlebit states;

    - rheumatic damage of soft tissues: tendovaginitis, bursitis, fibrositis, periarthritis;

    - Postoperative edema, concussion, dislocation, sprain.
    Contraindications:

    - Hypersensitivity to the components of the drug;

    - hypersensitivity to non-steroidal anti-inflammatory drugs (NSAIDs);

    - III trimester of pregnancy and the period of breastfeeding;

    - children under 14 years of age (due to lack of clinical experience);

    - violation of the integrity of the skin.

    Carefully:

    Simultaneous application of the drug with other NSAIDs, bronchial asthma, allergic rhinitis, polyps of the nasal mucosa.

    Pregnancy and lactation:Clinical experience, proving the safety of the drug when used during pregnancy and during lactation, is absent.The use of the drug is possible only if the expected benefit for the mother exceeds the potential risk to the fetus or child.
    Dosing and Administration:

    The gel is applied externally.

    3-4 times a day by rubbing the gel with a thin layer into the skin of the painful areas of the body. The amount needed for one rubbing is about 4-5 cm of the gel squeezed out from the tube. The total daily amount should not exceed 20 cm of gel. The duration of treatment should not exceed 10 days.

    Side effects:

    The tolerability of the drug is usually very good.

    Local reactions:

    May cause hypersensitivity symptoms of the skin - contact dermatitis, itching, redness, rash, sensation of heat and burning at the application site.

    Overdose:

    There is no information about cases of overdose with topical application.

    In case of accidental ingestion of large amounts of the drug may burning sensation in the mouth, salivation, nausea, vomiting.

    Treatment: washing of the mouth and stomach, if necessary - symptomatic treatment.

    Interaction:

    The gel can enhance the effect of drugs that cause photosensitivity.

    Clinically significant interaction with other drugs is not described.

    Special instructions:

    The drug should be applied only to undamaged skin areas, avoid contact with eyes and mucous membranes.

    After applying the drug, do not apply an occlusive bandage.

    In case of contact with eyes, mucous membranes or open wound surfaces, local irritation is observed - tearing, redness, burning, pain.

    The necessary measures in this case - washing the affected area with an abundant amount of distilled water or saline until the disappearance or reduction of complaints.

    Sodium benzoate and dimethylsulfoxide, contained in the preparation as auxiliary substances, can have an irritating effect on the skin.

    Effect on the ability to drive transp. cf. and fur:

    The drug has no effect on the ability to perform potentially hazardous activities requiring increased concentration of attention and speed of psychomotor reactions (including driving, working with moving mechanisms).

    Form release / dosage:

    Gel for external use.

    Packaging:

    For 40 grams in aluminum tubes, with an internal lacquer coating, a lithographed outer surface, a membrane and a sealing ring, with a polyethylene screw cap.

    Each tube, together with instructions for use, is placed in a cardboard pack.

    Storage conditions:

    At a temperature of no higher than 25 ° C.

    Keep out of the reach of children.
    Shelf life:

    2 years.

    Do not use after the expiration date
    Terms of leave from pharmacies:Without recipe
    Registration number:LP-003160
    Date of registration:31.08.2015
    Date of cancellation:2020-08-31
    The owner of the registration certificate:VetProm ADVetProm AD Bulgaria
    Manufacturer: & nbsp
    Representation: & nbspVETPROM ADVETPROM ADBulgaria
    Information update date: & nbsp21.10.2015
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