Pyrithione zinc has anti-inflammatory, antibacterial and antifungal activity. Antibacterial activity of zinc pyrithione is manifested in a number of Gram-positive and Gram-negative bacteria (Streptococcus spp., Staphylococcus spp., Escherichia coli, Pseudomonas aeruginosa, Proteus spp.). Pyrithione zinc reduces the intracellular level of ATP, contributes to the depolarization of cell membranes, causing the death of fungi and bacteria. Antifungal activity is especially pronounced in the case of fungi of the genus Malassezia (formerly Pityrosporum ovale and Pityrosporum orbiculare),causing inflammation and excessive desquamation in dandruff, seborrheic dermatitis, psoriasis and other skin diseases. The mechanism of anti-inflammatory action has not been studied.