Cytovir®-3 (Cytovir®-3)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceAlpha-glutamyl-tryptophan + Ascorbic acid + BendazoleAlpha-glutamyl-tryptophan + Ascorbic acid + Bendazole
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  • Cytovir®-3
    capsules inwards 
    CITOMED MB NPK, CJSC     Russia
  • Cytovir®-3
    powder inwards d / children 
    CITOMED MB NPK, CJSC     Russia
  • Cytovir®-3
    syrup inwards d / children 
    CITOMED MB NPK, CJSC     Russia
    • Dosage form: & nbsppowder for solution for oral administration [for children]
    Composition:

    Composition per 1 ml of the prepared solution

    Active substances:

    Alpha-glutamyl-tryptophan (Timogen sodium in terms of thymogen) 0.15 mg

    Ascorbic acid 12 mg

    Bendazole hydrochloride [Dibazol] 1.25 mg

    Excipients:

    In the preparation without flavor:

    Fructose 386.6 mg

    In the preparation with flavoring:

    Fructose 386.2 mg

    Flavor identical to natural

    "Orange" or "Cranberry", or "Strawberry" 0.4 mg

    Description:

    The powder is white or white with a yellowish hue.

    Aqueous solution without a smell or with a characteristic smell of orange or cranberry, or strawberry.

    Pharmacotherapeutic group:immunostimulating agent
    ATX: & nbsp

    L.03.A.X   Other immunostimulants

    Pharmacodynamics:

    PThe drug is a means of etiotropic and immunostimulating therapy, has an antiviral effect against influenza A and B viruses and other viruses that cause acute respiratory viral diseases.

    Bendazol induces in the body the production of endogenous interferon, has an immunomodulatory effect (normalizes the immune response of the body). Enzymes, the production of which is induced by interferon in the cells of various organs, inhibit the replication of viruses.

    Alpha-glutamyl-tryptophan (thymogen) is a synergistic immunomodulatory action of bendazole, normalizing the T-cell link of immunity.

    Ascorbic acid activates the humoral unit of immunity, normalizes the permeability of capillaries, thereby reducing inflammation, and exhibits antioxidant properties, neutralizing the oxygen radicals accompanying the inflammatory process, increases the body's resistance to infection.

    Pharmacokinetics:

    When ingested, the drug is completely absorbed from the gastrointestinal tract. Bioavailability of bendazole - about 80%, alpha-glutamyl-tryptophan - no more than 15%, ascorbic acid - up to 70%. Ascorbic acid absorbed in the digestive tract (mainly in the jejunum). Connection with plasma proteins - 25%. Tmah after ingestion of -4 hours. Easily penetrates into leukocytes, platelets, and then into all tissues, it penetrates the placenta.Diseases of the gastrointestinal tract (stomach ulcer and duodenal ulcer, intestinal motility disorders, helminthic invasion, giardiasis), the use of fresh vegetable and fruit juices, alkaline drink reduce the binding of ascorbic acid in the intestine. Metabolized ascorbic acid predominantly in the liver in deoxy-ascorbic, further into oxaloacetic and diketogulonic acid. It is excreted by the kidneys, through the intestines, with sweat, breast milk in unchanged form and in the form of metabolites. The products of biotransformation of bendazole in the blood are two conjugates formed as a result of methylation and carboethoxylation of the imidazole of the imidazole ring of bendazole: 1-methyl-2-benzylbenzimidazole and 1-carboethoxy-2-benzylbenzimidazole. Metabolites of bendazole are excreted in the urine. Alpha-glutamyl-tryptophan under the action of peptidases is split into L-glutamic acid and L-tryptophan, which are used by the body in protein synthesis.

    Indications:prevention and comprehensive therapy of influenza and acute respiratory viral infections in children from one year.
    Contraindications:hypersensitivity to the components of the drug, diabetes, pregnancy, children under 1 year.
    Pregnancy and lactation:

    AT Pregnancy is not indicated during pregnancy because of insufficient clinical data. In the period of breastfeeding, the application is possible if the intended benefit to the mother exceeds the potential risk to the child.

    Dosing and Administration:

    Patterns of therapeutic and prophylactic use are identical.

    Inside 30 minutes before meals.

    For children aged 1 to 3 years - 2 ml of solution 3 times a day;

    For children aged 3 to 6 years - 4 ml 3 times a day;

    For children aged 6 to 10 years - 8 ml 3 times a day;

    For children over the age of 10 years - 12 ml 3 times a day.

    The course of application - 4 days.

    Preventive course if necessary, repeat after 3-4 weeks.

    Rules for the preparation of the solution: add 40 ml of water to the vial of powder (boiled, cooled to room temperature), shake well. The content must completely dissolve. The volume of the solution after adding water is 50 ml.

    Side effects:Short-term decrease in blood pressure. Allergic reactions are possible: urticaria. In these cases, the drug is discontinued and symptomatic treatment, antihistamines, is prescribed.
    Overdose:cases of overdose are not described.
    Interaction:

    Interactions of alpha-glutamyl-tryptophan with drugs have not been identified.

    Bendazole - prevents an increase in OPSS caused by non-selective beta-blockers. Strengthens the hypotensive effect of antihypertensive and diuretic drugs. Fentolamine enhances the hypotensive effect of bendazole.

    Ascorbic acid - increases the concentration in the blood of benzylpenicillin and tetracyclines. Improves intestinal absorption of drugs Fe. Reduces the effectiveness of heparin and indirect anticoagulants. Acetylsalicylic acid (ASA), oral contraceptives, fresh juices and alkaline drink reduce its absorption and absorption. With simultaneous application with ASA, urinary excretion of ascorbic acid increases and the release of ASA decreases. ASA reduces the absorption of ascorbic acid by about 30%. Ascorbic acid increases the risk of developing crystalluria in the treatment of salicylates and sulfonamides short-acting, slows the excretion of acids by the kidneys, increases the excretion of drugs that have an alkaline reaction (including alkaloids), and reduces the concentration of oral contraceptives in the blood.With simultaneous use reduces the chronotropic effect of isoprenaline. Reduces the therapeutic effect of antipsychotic drugs (neuroleptics) - phenothiazine derivatives, tubular reabsorption of amphetamine and tricyclic antidepressants. Barbiturates and primidon increase the excretion of ascorbic acid in the urine.

    Special instructions:In the course of repeated courses, periodic monitoring of the concentration of glucose in the blood is recommended.
    Form release / dosage:Powder d / ready. r-ra d / ingestion (for children) 20 g.
    Packaging:

    For 20 g in a vial of dark glass or a polymer vial. The bottle is sealed with a plastic lid with a first opening control or a plastic lid with a first-opening control and protection from children. One bottle is placed in a pack of cardboard. Instructions for use are put in a pack or in the form of a folded sheet placed under the opening part of the label.

    In the bundle, a dosing device is inserted (measuring cup or spoon metering, or pipette dosing). It is allowed to put two metering devices in a pack (measuring cup and spoon dosing or measuring cup and pipette dosage).

    Storage conditions:

    Store in a dry place at a temperature of no higher than 25 ° C. Keep out of the reach of children.

    The prepared solution should be stored in a dark place at a temperature of 0 ° C to 8 ° C. Shelf life of the prepared solution is 10 days.

    Shelf life:3 years. Do not use after the expiration date printed on the package.
    Terms of leave from pharmacies:On prescription
    Registration number:PL-000423
    Date of registration:28.02.2011 / 29.02.2016
    Expiration Date:Unlimited
    The owner of the registration certificate:CITOMED MB NPK, CJSC CITOMED MB NPK, CJSC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp26.06.2014
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