Citramon-Lect (Citramon-LekT)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Dosage form: & nbsppills
Composition:
1 tablet contains
Active substances:
Acetylsalicylic acid 0.24 g,
Paracetamol 0.18 g,
Caffeine anhydrous 0.0275 g
(in terms of caffeine monohydrate 0.03 g).
Excipients: cocoa - 0,0225 g, citric acid - 0,005 g, potato starch - 0,06 g, calcium stearate - 0,005 g, talc - 0,01 g.
Description:Tablets of light brown color with impregnations, with a cocoa smell, round, flat-cylindrical form with a facet and a risk.
Pharmacotherapeutic group:Analgesic combined (analgesic non-narcotic remedy + psychostimulant + non-steroidal anti-inflammatory drug)
ATX: & nbsp
  • Acetylsalicylic acid in combination with psycholeptics
    • Pharmacodynamics:
    Combined drug.
    Acetylsalicylic acid has antipyretic and anti-inflammatory effect, relieves pain, especially caused by the inflammatory process, and also moderately inhibits platelet aggregation and thrombosis, improves microcirculation in the inflammatory focus.
    Caffeine increases the excitability of spinal cord reflex, excites the respiratory and vasomotor centers, dilates blood vessels in skeletal muscle, brain, heart, kidneys, reducing platelet aggregation; reduces drowsiness, fatigue. In this combination caffeine in a small dose practically does not have a stimulating effect on the central nervous system, however, it contributes to the regulation of the tonus of the vessels of the brain.
    Paracetamol has an analgesic antipyretic and weak anti-inflammatory effect, which is associated with its influence on the center of thermoregulation in the hypothalamus and a weak ability to inhibit the synthesis of prostaglandins (Pg) in peripheral tissues.
    Indications:Pain syndrome of mild and moderate severity (different genesis): headache, migraine, toothache, neuralgia, myalgia, arthralgia, algodismenorea. Feverish syndrome: with acute respiratory infections, influenza.
    Contraindications:
    - erosive-ulcerative lesions of the gastrointestinal tract in the phase of exacerbation;
    - gastrointestinal hemorrhages (including in the anamnesis);
    - severe violations of the liver and / or kidney function;
    - hemorrhagic diathesis, hypocoagulation, hemophilia, hypoprothrombinemia;
    - surgical interventions, accompanied by heavy bleeding;
    - pregnancy (I and III trimester), lactation period;
    - deficiency of glucose-6-phosphate dehydrogenase;
    - glaucoma;
    - hypersensitivity to the components of the drug;
    - bronchial asthma, induced by the use of acetylsalicylic acid, salicylates and other non-steroidal anti-inflammatory drugs, complete or incomplete combination of bronchial asthma; recurrent polyposis of the nose and paranasal sinuses and intolerance to ASA or other non-steroidal anti-inflammatory drugs (including in the anamnesis);
    - Children's age (under 15 years - the risk of developing Reye's syndrome in children with hyperthermia in the presence of viral diseases);
    - increased excitability, sleep disturbance;
    - organic diseases of the cardiovascular system (including acute myocardial infarction, atherosclerosis);
    - severe arterial hypertension;
    - portal hypertension;
    - avitaminosis K;
    - hypoproteinemia.
    Carefully:Renal failure of mild and moderate degree, pregnancy (II trimester), hepatic failure with increased activity of "liver" transaminases, benign hyperbilirubinemia (including Gilbert's syndrome), alcoholic liver damage, alcoholism, epilepsy and propensity to convulsive seizures, advanced age , gout.
    Pregnancy and lactation:Pregnancy (I and III trimester) and the period of breastfeeding the drug is not prescribed.
    Dosing and Administration:The drug should not be taken more than 5 days as an analgesic drug and more than 3 days - antipyretic (without appointment and supervision of a doctor).
    Inside (during or after a meal), 1 tablet every 4 hours, with a pain syndrome - 1-2 tablets; the average daily dose is 3-4 tablets, the maximum daily dose is 8 tablets. The course of treatment - no more than 3-5 days. To reduce the irritant effect, the gastrointestinal tract should be washed down with a tablet of milk or alkaline mineral water.
    Side effects:
    Side reactions typical of acetylsalicylic acid, paracetamol and caffeine can be observed: anorexia, nausea, vomiting, Reye syndrome in children, gastralgia, decreased platelet aggregation, erosive and ulcerative lesions of the gastrointestinal tract, gastrointestinal bleeding, allergic reactions, bronchospasm, multiforme exudative erythema (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome), renal insufficiency, hepatic insufficiency, dizziness, tachycardia, increased arter cial pressure.
    With prolonged use - dizziness, headache,blurred vision, tinnitus, decrease platelet aggregation, hypocoagulation, hemorrhagic syndrome (epistaxis, bleeding gums, and Purpura et al.), renal papillary necrosis with loss; deafness, Reye's syndrome in children, hyperpyrexia, metabolic acidosis, disorders of the nervous system and psyche, vomiting, abnormal function of the liver.
    Overdose:
    Do not exceed the recommended dose and duration of use!
    Symptoms:
    - with slight intoxication: nausea, vomiting, stomach pain, dizziness, ringing in the ears;
    - in severe intoxication: sedation, drowsiness, collapse, convulsions, difficulty breathing, anuria, bleeding.
    Treatment: gastric lavage using activated charcoal, symptomatic therapy, depending on the metabolic state of sodium nutshell hydrogencarbonate, sodium citrate or sodium lactate, it increases the excretion of acetylsalicylic acid due to alkalization of urine.
    Interaction:

    Acetylsalicylic acid.

    Enhances the toxicity of methotrexate, reducing its renal klireks, enhances the effects of narcotic analgesics (oxycodone, propoxyphene, codeine), oral antidiabetic drugs, heparin, indirect anticoagulants, thrombolytic agents and platelet aggregation inhibitors, reduces the effect of uricosuric medicines (benzbromarone, sulfipirazone), antihypertensive drugs, diuretics (spironolactone, furosemide).

    Glucocorticoids, ethanol and ethanol-containing drugs increase the negative effect on the mucous membrane of the gastrointestinal tract and increase the clearance. Increases the concentration of digoxin, barbiturates, lithium salts in plasma. Antatsida containing magnesium and / or aluminum, slow down and worsen the absorption of acetylsalicylic acid. Myelotoxic drugs increase the manifestation of hematotoxicity of acetylsalicylic acid.

    Paracetamol.

    Barbiturates, rifampicin, salicylamide, antiepileptic drugs and other inducers of microsomal liver enzymes contribute to the formation of toxic metabolites of paracetamol that affect liver function. Metoclopramide accelerates the absorption of paracetamol.

    Under the influence of paracetamol, the half-life of chloramphenicol increases five-fold. At repeated reception paracetamol can enhance the effect of anticoagulants (coumarin derivatives).

    Caffeine.

    Caffeine is an adenosine antagonist (large doses of adenosine may be required). With the joint use of caffeine, and barbiturates, primidon, anticonvulsant drugs, disulfiram, ciprofloxacin, norfloxacin - a decrease in the metabolism of caffeine in the liver (slowing its elimination and increase in blood concentrations). Caffeine-containing beverages and other medicines that stimulate the central nervous system may cause excessive stimulation of the central nervous system.

    Mexiletine - reduces the excretion of caffeine to -50%; nicotine - Increases the speed of caffeine removal.

    Inhibitors of monoamine oxidase, furazolidone, procarbazine and selegiline - Large doses of caffeine can cause the development of dangerous cardiac arrhythmias or a marked increase in blood pressure.

    Caffeine accelerates the absorption of ergotamine. Caffeine reduces the absorption of calcium in the gastrointestinal tract. Reduces the effect of narcotic and hypnotic drugs. Increases the excretion of lithium drugs with urine.

    Accelerates absorption and enhances the action of cardiac glycosides, increases their toxicity.

    Joint use of caffeine with beta-blockers can lead to mutual suppression of therapeutic effects; with adrenergic bronchodilator drugs - to additional stimulation of the central nervous system and other additive toxic effects. Caffeine can reduce the clearance of theophylline and, possibly, other xanthines, increasing the possibility of additive pharmacodynamic and toxic effects.

    Special instructions:Do not prescribe the drug to children under 15 due to the high risk of developing Reye's syndrome. Reye's syndrome is manifested by prolonged vomiting, acute encephalopathy, enlargement of the liver.
    Acetylsalicylic acid slows blood clotting. If a patient is to undergo surgery, a doctor should be warned in advance about taking the drug.
    In patients with a predisposition to accumulation of uric acid, taking the drug may trigger a gout attack.
    During the intake should be refrained from drinking, alcohol (increased risk of gastrointestinal bleeding and toxic damage to the liver).
    Acetylsalicylic acid when used in the first trimester of pregnancy has a teratogenic effect; in the III trimester leads to inhibition of labor:
    Excreted in breast milk; therefore, application during lactation is contraindicated.
    With continued use of the drug, control of peripheral blood and the functional state of the liver is necessary.
    Effect on the ability to drive transp. cf. and fur:The presence of caffeine in the composition of the drug may lead to insomnia in people with increased excitability, a feeling of anxiety, so during the treatment period one should refrain from driving and performing work requiring increased attention and reaction speed.
    Form release / dosage:Pills.
    Packaging:For 10 tablets in a contiguous, non-jellied package or a contiguous cell package.
    1 or 2 contour squares, together with instructions for use, are placed in a pack of cardboard.
    It is allowed to pack contour packs without a bundle in a group container when the instructions for use are enclosed in an amount sufficient to supply each outline package.
    Storage conditions:In the dark place at a temperature of no higher than 25 ° C.Keep out of the reach of children.
    Shelf life:
    4 years.
    Do not use after expiry date.
    Terms of leave from pharmacies:Without recipe
    Registration number:LP-001188
    Date of registration:11.11.2011
    The owner of the registration certificate:Tyumen Chemical - Pharmaceutical Plant, OJSC Tyumen Chemical - Pharmaceutical Plant, OJSC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp01.02.2017
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