Inside. Children and adults with a body weight of less than 34 kg are recommended to use the drug in the form of a suspension.
Dissolution of cholesteric gallstones:
The recommended dose is 10 mg / kg / day, which corresponds to:
Body weight, kg | Number of capsules, pcs. |
up to 60 | 2 |
61-80 | 3 |
81-100 | 4 |
Over 100 | 5 |
The drug should be taken daily in the evening, before going to bed (capsules are not chewed), squeezed with a small amount of liquid. The duration of treatment is 6-12 months. For the prevention of repeated cholelithiasis, the use of the drug is recommended for several months after the dissolution of the stones.
Treatment of biliary reflux gastritis:
1 capsule of the drug every evening, before going to bed (capsules are not chewed), with a small amount of water. The course of treatment - from 10-14 days to 6 months, if necessary - up to 2 years.
Symptomatic treatment of primary biliary cirrhosis:
The daily dose depends on the body weight and is from 3 to 7 capsules (approximately 14 ± 2 mg / kg ursodeoxycholic acid per 1 kg of body weight).
In the first 3 months of treatment, the 250 mg capsule preparation should be divided into several doses during the day.After improving liver function, the daily dose of the drug can be taken 1 time in the evening.
The following application mode is recommended:
250 mg capsules
Body weight, kg | Daily dose (capsules, pieces) | In the morning | In the afternoon | In the evening |
47-62 | 3 | 1 | 1 | 1 |
63-78 | 4 | 1 | 1 | 1 |
79-93 | 5 | 1 | 2 | 2 |
94-109 | 6 | 2 | 2 | 2 |
Over 109 | 7 | 2 | 2 | 3 |
Capsules should be taken regularly, without chewing, with a small amount of liquid.
The use of the drug for the treatment of primary biliary cirrhosis can be continued for an unlimited time. In patients with primary biliary cirrhosis, in rare cases, clinical symptoms may worsen at the beginning of treatment, for example, itching may increase. In this case, the treatment should continue, taking 1 capsule daily, then gradually increase the dosage (increasing the daily dose weekly by 1 capsule) until the recommended dosage regimen is again achieved.
Primary sclerosing cholangitis:
12-15 mg / kg / day (up to 20 mg) for 6-24 months (up to several years).
Cystic Fibrosis:
Up to 20-30 mg / kg / day for 6-24 months or more.
Chronic hepatitis of various genesis, non-alcoholic steatohepatitis, alcoholic liver disease:
The daily dose is 12-15 mg / kg (2-5 capsules in 2-3 doses, the duration of therapy is 6-12 months or more).
Biliary dyskinesia:
The average daily dose is 10 mg / kg in 2 divided doses for 2 weeks to 2 months.
Children over 3 years old the drug is administered individually, based on a calculation of 20 mg / kg / day.