The drug is used rectally.1 suppository contains, as active substance, human recombinant interferon alpha-2b at indicated dosages (150,000 IU, 500,000 IU, 1,000,000 IU, 3,000,000 IU).
In the complex therapy of various infectious and inflammatory diseases in newborn children, including premature infants: newborns, including preterm infants with a gestational age of more than 34 weeks, appoint VIFERON® 150000 ME daily for 1 suppository 2 times a day after 12 hours. The course of treatment is 5 days.Preterm infants with gestational age less than 34 weeks are prescribed VIFERON® 150000 ME daily for 1 suppository 3 times a day after 8 hours. The course of treatment is 5 days.
The recommended number of courses for various infectious and inflammatory diseases in children, including newborns and prematurity: ARVI, including influenza, including those complicated by bacterial infection - 1-2 courses; pneumonia (bacterial, viral, chlamydial) 1-2 courses, sepsis 2-3 courses, meningitis 1-2 courses, herpetic infection 2 courses, enterovirus infection 1-2 courses, cytomegalovirus infection -2-3 courses, mycoplasmosis , candidiasis, including visceral, - 2-3 courses. The break between the courses is 5 days.According to clinical indications, therapy can be continued.
In the complex therapy of chronic viral hepatitis B, C, D in children and adults: children with chronic viral hepatitis drug prescribed in the following dose levels: up to 6 months 300000-500000 ME per day; from 6 to 12 months - 500,000 IU per day. At the age from 1 year to 7 years - 3 million ME at 1 m2 body surface area per day. At the age of over 7 years - 5000000 ME per 1 m2 body surface area per day. Calculation of the dose of the drug for each particular patient is made by multiplying the recommended dose for the given age by the body surface area, calculated from the nomogram to calculate the surface area of the body in terms of height and weight according to Garford, Terry and Rourke, divided into 2 injections, rounded to the dosage of the corresponding suppository. The drug is used 2 times a day at 12 h the first 10 days daily, then three times a week every other day for 6-12 months. The duration of treatment is determined by clinical efficacy and laboratory parameters.
Children with chronic viral hepatitis of marked activity and cirrhosis prior to plasmapheresis and / or hemosorption show the use of the drug for 14 days daily for 1 suppository 2 times a day after 12 hours (children under 7 years old VIFERON® 150000 ME, children over 7 years - VIFERON® 500,000 ME).
Adults with chronic viral hepatitis are prescribed VIFERON® 3,000,000 IU at 1 suppository 2 times a day after 12 hours for 10 days daily, then three times a week every other day for 6-12 months. The duration of treatment is determined by clinical efficacy and laboratory performance.
In complex therapy in adults, including pregnant women, with urogenital infection (chlamydia, cytomegalovirus infection, ureaplasmosis, trichomoniasis, gardnerellez, papillomavirus infection, bacterial vaginosis, recurrent vaginal candidiasis, mycoplasmosis), with primary or recurrent herpetic infection of the skin and mucous membranes ( a localized form, an easy, moderate course, including the urogenital form).
Adults, with the above infections, except herpetic, appoint VIFERON® 500000 ME per 1 suppository 2 times a day after 12 hours. Course 5-10 days. According to clinical indications, therapy can be continued with interruptions between courses of 5 days.
When herpetic infection is prescribed VIFERON® 1000000 ME per 1 suppository 2 times a day after 12 hours. The course of treatment is 10 days or more with a recurrent infection.It is recommended to start treatment immediately with the appearance of the first signs of skin and mucous membrane damage (itching, burning, redness). In the treatment of recurrent herpes it is desirable to begin treatment in the prodromal period or at the very beginning of the manifestation of signs of relapse.
In pregnant women with urogenital infection, including herpetic infection, in the second trimester of pregnancy (starting from week 14) - VIFERON® 500000 ME per 1 suppository after 12 hours (2 times per day) for 10 days, then 1 suppository after 12 hours (2 times a day) twice a week - 10 days. After 4 weeks, preventive courses of the preparation VIFERON® 150000 ME per 1 suppository every 12 hours - for 5 days, the preventive course is repeated every 4 weeks. If necessary, it is possible to conduct a treatment course before childbirth.
In the complex therapy of acute respiratory viral infections, including influenza, including those complicated by bacterial infection in adults. Apply VIFERON® 500000 ME to 1 suppository 2 times a day after 12 hours daily. The course of treatment is 5-10 days.