Iron chloride (Ferri chloridum)

Pharmacodynamics Pharmacokinetics Indications Carefully Contraindications Dosing and Administration Side effects
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Clinical and pharmacological group: & nbsp

Macro and microelements

Stimulators of hematopoiesis

Included in the formulation
  • Hemofer
    drops inwards 
    AKRIKHIN HFK, JSC     Russia
    • АТХ:

    B.03.A.A.05   Iron chloride

    Pharmacodynamics:

    Pharmacological action - anti-anemic.

    Increases the iron content in the body, stimulates erythropoiesis, reversibly binds oxygen and regulates the oxidation-reduction reactions of the body. With the course of iron treatment with iron deficiency chloride, regression of clinical symptoms (circulatory-hypoxic and dystrophic syndromes: asthenia, dizziness, tachycardia, dry skin, fragility of nails, etc.) and altered laboratory parameters (hypochromic anemia, decrease in serum iron level, ).

    Pharmacokinetics:

    Ferric chloride is in a plastic matrix - a graduate. The gradual release of iron occurs mainly in the duodenum and upper parts of the small intestine. The process of the liberation of the active substance depends on the presence of the liquid. The plastic matrix is ​​removed from the body with feces.

    The absorbed iron is retained in the ferritin-related form, mainly in the liver. There is a correlation between the degree of deficiency and the amount of absorbed iron (the higher the iron deficiency, the better the absorption). With clinically severe anemia, iron absorption reaches 25%.

    Indications:

    Iron deficiency anemia, latent iron deficiency. Prophylaxis of iron deficiency during pregnancy and lactation, intensive growth in children and adolescents, in adults (vegetarians and elderly people).

    ICD-10

    III.D50-D53.D50.9   Iron deficiency anemia, unspecified

    Contraindications:

    Hypersensitivity, hemochromatosis, hemosiderosis.

    Carefully:

    Anemia of non-iron deficiency, a tendency to dermatitis or allergic reactions, inflammatory diseases of the digestive tract.

    Pregnancy and lactation:

    It is used for prescription to prevent iron deficiency during pregnancy and lactation.

    Dosing and Administration:

    The dosage regimen is set individually.

    For medicinal purposes:

    Premature infants - daily 1.5-3.0 mg of iron (II) / kg of body weight (1-2 drops) for 3 to 5 months.

    Children under 1 year - every day 15-30 mg (9-19 drops) per day.

    Children from 1 year to 12 years - daily 45 mg (28 drops) 1-2 times a day.

    Children older than 12 years - daily 45 mg (28 drops) 2 times a day.

    Adults - daily 55 drops (2 ml) 2 times a day.

    The therapeutic dose for children should not exceed 3 mg / kg per day, for adults - 180-200 mg per day.

    Prophylactic doses are 1 / 2-1 / 3 of therapeutic.

    Duration of treatment at least 2 months. Dosage and timing of treatment depend on the degree of iron deficiency. In the case of clinically pronounced iron deficiency, the hemoglobin level normalizes only after 2-3 months after the start of treatment. After this, to restore iron stores in the body, taking the drug in preventive doses should be continued for several months.

    Side effects:

    Headache, skin flushing, allergic reactions (itching, rash), nausea, vomiting, constipation or diarrhea, abdominal pain.

    Overdose:

    Symptoms: pain in the epigastrium, nausea, vomiting, diarrhea or constipation, lowering of arterial pressure, in more severe cases - drowsiness, pallor, necrosis of the gastrointestinal mucosa, hypovolemic shock, up to coma. Symptoms of peripheral circular collapse appear within 30 minutes after administration; metabolic acidosis, convulsions, fever, leukocytosis, coma - within 12-24 hours; acute renal and hepatic necrosis - after 2-4 days.

    Treatment: drug cancellation, gastric lavage, prescription of laxatives, symptomatic therapy; in case of severe poisoning - deferoxamine intravenously slowly: children - 15 mg / h, adults - 5 mg / kg / h (up to 80 mg / kg per day); with mild poisoning intramuscularly: children 1 g every 4-6 hours, adults - 50 mg / kg (up to 4 g per day).

    Interaction:

    Incompatible with drugs containing SH-group: bismuth colloidal citrate, calcium phosphate, chloramphenicol, colestramine, colestipol, tetracyclines, pancreatin, zinc salts can reduce the effectiveness of the drug.

    Ascorbic acid increases the absorption of iron ions.

    The drug may reduce the effectiveness of quinolones, levodopa, levothyroxine, methyldopa, tetracyclines, penicillin, sulfasalazine, and zinc salts.

    Simultaneous use of iron salts and allopurinol should be avoided.

    Food, mainly milk and its products, as well as eggs, reduce the absorption of the drug.

    Special instructions:

    To avoid darkening of the teeth, you can take the drug as a solution for drinking through a tube.

    When a liquid stool appears, the single dose should be reduced, but the multiplicity of the appointment should be increased.

    As a result of the elevated iron content in the intestine, during treatment with the drug, the stool may be darker, which has no clinical significance.

    It is not recommended to appoint if there is a violation of the processes of digestion and absorption in the digestive tract.

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