Iron sulphate + Folic acid (Ferri sulfas + Acidum folicum)

Pharmacodynamics Pharmacokinetics Indications Carefully Contraindications Dosing and Administration Side effects
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Clinical and pharmacological group: & nbsp

Macro and microelements

Stimulators of hematopoiesis

Included in the formulation
  • Gyno-Tardiferon®
    pills inwards 
    Pierre Fabre Medication Production     France
    • АТХ:

    B.03.A.D.03   Iron sulphate in combination with folic acid

    Pharmacodynamics:

    Iron sulfate is a salt of iron, a microelement necessary for the synthesis of hemoglobin. Iron is a part of hemoglobin, myoglobin and a number of enzymes. When iron is used in the form of salts, its deficiency in the body is rapidly replenished, which leads to a gradual regression of clinical (weakness, fatigue, dizziness, tachycardia, tenderness and dry skin) and laboratory symptoms of anemia.

    Folic acid is necessary for the normal maturation of megaloblasts and the formation of normoblasts. Stimulates erythropoiesis, participates in the synthesis of amino acids, nucleic acids, purines and pyrimidines, in the exchange of choline. When pregnancy protects the body from the effects of teratogenic factors.

    Pharmacokinetics:

    After taking the drug, iron is absorbed from the digestive tract. Bioavailability of iron is 10-30%. The gradual release of iron allows prolonging its absorption, mainly in the distal part of the small intestine.

    Binding of iron with plasma proteins - 90% or more.Deposited in the form of ferritin or hemosiderin in the cells of the phagocytic macrophage system, a small amount - in the form of myoglobin in the muscles. Iron is excreted with feces, urine and sweat.

    Folic acid is absorbed mainly from the upper parts of the digestive tract (duodenum). The binding of folic acid with plasma proteins is 64%; biotransformation occurs in the liver. Folic acid is excreted mainly by the kidneys, partly by the intestine.

    Indications:

    Treatment and prevention of iron deficiency anemia of various etiologies (including in pregnancy, with violations of iron absorption from the gastrointestinal tract, with prolonged bleeding, with inadequate and unbalanced nutrition).

    ICD-10

    XV.O95-O99.O99.0   Anemia complicating pregnancy, childbirth and the puerperium

    III.D50-D53.D52   Folic deficiency anemia

    III.D50-D53.D50   Iron-deficiency anemia

    XV.O20-O29.O25   Malnutrition in pregnancy

    IV.E50-E64.E61.1   Insufficiency of iron

    XV.O95-O99.O99   Other maternal illnesses classified elsewhere, but complicating pregnancy, childbirth and the puerperium

    Contraindications:

    - Anemia not associated with iron or folate deficiency (hemolytic anemia, megaloblastic anemia associated with isolated vitamin B deficiency12);

    - increased iron content in the body (hemosiderosis);

    - violation of iron utilization mechanisms (anemia caused by lead poisoning, sidero-achestic anemia);

    - stenosis of the esophagus and / or obstructive changes in the gastrointestinal tract;

    - Children's age (under 18 years);

    - Hypersensitivity to the components of the drug.

    Carefully:

    With caution should take the drug for inflammatory bowel disease, alcoholism, liver or kidney failure.

    Pregnancy and lactation:

    For the prevention of iron deficiency and folic acid during pregnancy and lactation, the drug is prescribed 1 tablet per day in the II and III trimesters and the postpartum period during lactation.

    Dosing and Administration:

    Inside, after meal. Treatment - 1 tablet 2 times a day; prophylaxis - 1 tablet once a day (with pregnancy starting from the 24th week); during lactation - 1 tablet per day during the entire lactation period. The course of treatment is to normalize the hemoglobin content with the subsequent administration of 1 tablet per day for 1-3 months.

    Side effects:

    From the digestive system: rarely - nausea, epigastric pain, diarrhea, constipation.

    Overdose:

    Symptoms: irritation of the digestive tract.

    Treatment: induce vomiting, rinse the stomach using 1% aqueous solution of sodium bicarbonate or designate deferoxamine; take in raw eggs and milk, which will ensure the binding of iron ions in the digestive tract and their subsequent excretion.

    Interaction:

    Avoid concomitant administration with other iron-containing drugs (risk of overdose).

    Reduce absorption: antacid drugs, calcium preparations, etidronic acid, drugs that reduce the acidity of gastric juice (including cimetidine, medicines containing carbonates, hydrocarbonates, phosphates, oxalates), pancreatin, pancreolipase, coffee, tea, milk, vegetables, cereals, egg yolk (iron preparations should be taken 1 hour before or 2 hours after they are consumed).

    Increase absorbability: ascorbic acid, ethanol (including increases the risk of toxic complications).

    The drug reduces the absorption of fluoroquinolones, penicillamine, tetracyclines, at high doses reduces the absorption of zinc preparations (they are recommended to be taken 2 hours before or 2 hours after taking the iron preparation).

    Special instructions:

    Before starting therapy with the drug it is necessary to determine the content of iron and ferritin in the blood serum.

    During the period of taking the drug, a dark colouration of the stool can be observed, which is due to the removal of not absorbed iron and has no clinical significance.

    Effective only with iron deficiency anemia and ineffective in anemia of other etiology.

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