Clinical and pharmacological group: & nbsp

Other immunomodulators

Included in the formulation
  • Timogen®
    spray nazal. 
  • Timogen®
    cream externally 
  • Timogen®
    solution w / m 
  • АТХ:

    L.03.A.A   Colony-stimulating factors

    Pharmacodynamics:

    Synthetic dipeptide, consisting of amino acid residues - glutamine and tryptophan.

    Stimulates cellular factors of immunogenesis, proliferation and differentiation of T-lymphocyte precursors into mature immunocompetent cells, normalizes the T-helper / T-suppressor ratio, increases cAMP concentration in T-lymphocyte progenitors. Strengthens nonspecific resistance of the organism, promotes the activation of phagocytic functions of neutrophils and monocytes / macrophages; stimulates interferonogenesis and the function of natural killers (in low doses). Has antimediator properties. Highly effective in immunodeficiencies of T-suppressor type. Stimulates regeneration processes in case of their inhibition. Improves the course of the processes of cellular metabolism.

    Pharmacokinetics:The drug quickly enters the systemic bloodstream after its parenteral administration. It is cleaved by peptidases to L-glutamine and L-tryptophan, which the body uses in peptide synthesis. Half-life - 3 hours.
    Indications:

    Complex therapy of acute and chronic infectious and inflammatory diseases, accompanied by a decrease in the parameters of cellular immunity.

    Prevention of infectious complications, suppression of immunity, hematopoiesis, regeneration processes in the post-traumatic and postoperative period.

    In the process of radiotherapy or chemotherapy.

    When using massive doses of antibiotics.

    Prophylaxis and complex therapy of viral and bacterial infections, acute and chronic respiratory diseases.

    In the complex therapy of severe diffuse forms of atopic dermatitis.

    Diseases of the skin and subcutaneous tissue (pyoderma, furunculosis, erysipelatous inflammation).

    In complex therapy of severe mechanical, chemical, radiation and thermal injuries (burn disease).

    III.D80-D89.D84.9   Immunodeficiency, unspecified

    X.J30-J39.J39.9   Disease of upper respiratory tract, unspecified

    XIX.T08-T14.T14   Injury of unspecified site

    XIX.T08-T14.T14.1   Open wound of unspecified area of ​​the body

    XIX.T36-T50.T36   Antibiotic poisoning of systemic action

    XXI.Z20-Z29.Z29.1   Prophylactic immunotherapy

    XXI.Z40-Z54.Z51.0   Radiotherapy course (supportive)

    XXI.Z40-Z54.Z51.1   Chemotherapy for neoplasm

    XXI.Z40-Z54.Z51.2   Other types of chemotherapy

    Contraindications:Hypersensitivitypregnancy, breast-feeding, children under 6 months.
    Carefully:No data.
    Pregnancy and lactation:The category of FDA recommendations is not defined. Qualitative and well-controlled studies on humans and animals have not been conducted. Do not apply! There is no information on the penetration into breast milk. Do not apply!
    Dosing and Administration:

    Intramuscularly, intranasally.

    A solution of 0.01%. Recommended doses for intramuscular and intranasal (daily dose is administered at one time): adults - 50-100 mcg (300-1000 mcg per 1 course); children under 1 year - 10 mcg, 1-3 years - 10-20 mcg, 4-6 years - 20-30 mcg, 7-14 years - 50 mcg. The duration of treatment is 3-10 days and depends on the severity of immunity disorders. If necessary, repeat the course in 1-6 months. For prophylactic purposes, apply intranasally daily: adults - 50-100 mcg, children - 10-50 mcg for 3-5 days.

    Spray dosed (25 mcg / dose). Adults - 1 dose per each nasal passage 2 times a day; children from 1 year to 6 years - 1 dose in one nostril, 7-14 years - 1 dose in each nasal passage 1 time per day.Duration of application - 10 days with a therapeutic purpose or 3-5 days for the prevention. The repeated course is conducted not earlier than in 1 month.

    Side effects:Allergic reactions.
    Overdose:At a 10-fold excess of a single dose with intranasal administration in the form of a spray dosed (25 mcg / dose), an influenza-like syndrome is possible that disappears after the drug is withdrawn.
    Interaction:

    Glucocorticosteroids (high doses) - do not apply.

    Cytostatics, radiation therapy - increasing the effectiveness of therapy.

    Special instructions:

    Treatment with the drug is carried out under the control of indicators of immune status.

    There are data on the effectiveness of use as an immunomodulator in the complex therapy of viral hepatitis, tuberculosis, pseudotuberculosis, influenza and acute respiratory viral infections, papillomatosis, sepsis.

    According to clinical studies, the use in the acute period of the disease in the intestinal form of amoebiasis, typhoid fever, acute dysentery, erysipelas, diphtheria, brucellosis, hemorrhagic fever with renal syndrome improves the health of patients, promotes faster normalization of biochemical and immunological parameters.As a result of the use of the drug, the frequency of the occurrence of a prolonged recurrent course of diseases and the chronization of the process is reduced.

    The use of infectious inflammatory and allergic etiology in bronchopulmonary diseases can shorten the duration of the disease, restore the activity of the immune system and prevent or significantly reduce the likelihood of complications.

    According to clinical studies, the drug is successfully used in the complex therapy of bacterial, viral and fungal skin infections (pyoderma, furunculosis, erysipelas, papillomatosis, herpes), as well as in the treatment of atopic dermatitis.

    In the medical literature, reports on the use of acute pancreatitis, peritonitis, in severe mechanical injuries, prolonged squeezing syndrome, burns, in the treatment and rehabilitation of patients after large cavitary operations have been published as part of a complex therapy.

    Impact on the ability to drive vehicles and manage mechanisms

    The drug does not affect the ability to drive vehicles and engage in other potentially hazardous activities,requiring increased concentration of attention and speed of psychomotor reactions.

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