Antarage (Antareyt)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceMagdrate + SimethiconeMagdrate + Simethicone
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  • Antarage
    pills inwards 
    REMEDIYA, LLC     Russia
    • Dosage form: & nbspchewing tablets
    Composition:

    1 tablet chewing dosage of 400/20 mg contains:

    Active substances: magdrate - 400 mg, simethicone (in terms of dimethylpolysiloxane) 30.77 (20) mg.

    Excipients: ethyl cellulose -18.0 mg, macrogol-4000- 70.0 mg, sorbitol-256.59 mg, sucralose-2.16 mg, aspartame-2.50 mg, caramel flavoring-6.48 mg, silicon colloidal dioxide-4 , 5 mg, glyceryl dibehenate 9.0 mg.

    1 tablet chewing dose of 800/40 mg contains:

    Active substances: Magalite - 800 mg, simethicone (in terms of dimethylpolysiloxane) - 61.54 (40) mg.

    Excipients: ethylcellulose 36.00 mg, macrogol 4000 to 140.0 mg, sorbitol 513.18 mg, sucralose 4.32 mg, aspartame 5.0 mg, caramel flavor 12.96 mg, colloidal silicon dioxide 9 , 0 mg, glyceryl dibehenate - 18.0 mg.

    Description:Biconvex tablets white or almost white, octagonal, with beveled edges, with an engraved apple and the letter "g" on one side. Presence of dark inclusions is allowed.
    Pharmacotherapeutic group:Antacid agent + carminative agent
    ATX: & nbsp

    A.02.A.F   Antacids in combination with drugs that reduce gassing in the intestine

    A.02.A.F.01   Magadrat and carminative preparations

    A.02.A.F.02   A simple combination of salts and carminative drugs

    Pharmacodynamics:

    Combined drug, the effect of which is due to the properties that make up its components. Has antacid, adsorbing, enveloping, carminative effect.

    Magaldrat

    Magaldrate (aluminum magnesium hydroxide sulfate) neutralizes free hydrochloric acid in the stomach, without causing secondary hypersecretion of gastric juice. In connection with the increase in pH during its intake, the peptic activity of gastric juice decreases. It has an adsorbent and enveloping effect, due to which the effect of damaging factors on the gastric mucosa decreases, binds bile acids.

    Simethicone

    Simethicone changes the surface tension of gas bubbles formed in the contents of the stomach and mucus of the intestine, and causes their destruction. The gases released in this way can be absorbed by the cells of the walls of the intestine, or be excreted by peristalsis. Simethicone removes foam purely physically, does not enter into chemical reactions, is pharmacologically inert.

    Pharmacokinetics:

    Magaldrat

    Absorption of aluminum and magnesium ions in the blood is low. With normal kidney function, the concentration of aluminum and magnesium in the blood does not change.In patients with chronic renal insufficiency, the content of aluminum and magnesium in the blood can rise to toxic values ​​as a result of disruption of their excretion.

    Simethicone

    Simethicone due to pharmacological and chemical inertness after ingestion is not absorbed into organs and tissues. After passing through the gastrointestinal tract (GASTROINTESTINAL TRACT) is excreted unchanged by the intestine.

    Indications:Symptoms associated with increased acidity of gastric juice and reflux esophagitis: heartburn, belch "sour taste", pain in the stomach (there are irregular), a feeling of overflow or heaviness in the epigastric region, flatulence, dyspepsia (including, due to inaccuracy in the diet , medication, alcohol, coffee, nicotine abuse).
    Contraindications:Hypersensitivity to the components of the drug; severe renal insufficiency; hypophosphatemia; intolerance to fructose (due to the presence of sorbitol in the formulation); children under 12 years.
    Carefully:With renal insufficiency (with prolonged admission, an increase in the magnesium and aluminum content in the blood plasma is possible); Alzheimer's disease; at lowthe content of phosphates in food (the risk of developing phosphate deficiency).
    Pregnancy and lactation:

    Controlled clinical studies with study of the use of the drug Antareitis in pregnant women have not been carried out, however, in pre-clinical studies, the teratogenic effect or action was not detected. In connection with the lack of clinical experience, the use of the drug during pregnancy is possible only if the benefit from its use for the mother exceeds the potential risk to the fetus. Avoid prescribing the drug during pregnancy in large doses and for a long time.

    During the reception of the drug, the Antareit is not required to stop breastfeeding.

    Dosing and Administration:

    Inside. Tablets should be thoroughly chewed or kept in the mouth until completely absorbed.

    Adults and adolescents over 12 years of age: if the doctor is not recommended otherwise, 1 -2 tablets taken shortly after meals. If necessary, you can repeat the drug after 2 hours.

    The maximum daily dose for tablets is 400/20 mg -16 tablets; for tablets 800/40 mg - 8 tablets.

    Side effects:Allergic reactions, nausea, vomiting, taste disorders, constipation, diarrhea.With long-term admission in high doses - hypophosphatemia, hypocalcemia, hypercalciuria, osteomalacia, osteoporosis, hypermagnesia, hyperaluminia, encephalopathy, nephrocalcinosis, renal dysfunction. In patients with concomitant renal failure - a sense of thirst, lowering blood pressure, hyporeflexia.
    Overdose:

    Symptoms: with prolonged intake of high doses, the formation of kidney stones, constipation, drowsiness, hypermagnesia. There may also be signs of metabolic alkalosis: mood lability, numbness or muscle pain, nervousness and fatigue, unpleasant gustatory sensations.

    Treatment: it is necessary to take measures to quickly remove the drug: rinse the stomach, induce vomiting, take Activated carbon.

    Interaction:Antareit reduces and slows down the absorption of digoxin, indomethacin, salicylates, chlorpromazine, phenytoin, H2-gistaminoblockers, beta-blockers, diflunizal, isoniazid, tetracycline antibiotics, quinolones (ciprofloxacin, norfloxacin, ofloxacin, enoxacin, gropofloxacin, etc.), azithromycin, cefpodoxime, pivamgscillin, rifampicin,indirect anticoagulants, barbiturates, fexofenadine, dipyridamole, zalcitabine, bile acids - chenodeoxycholic and ursodeoxycholic, penicillamine, iron and lithium preparations, quinidine, lansoprazole, mexiletine, ketoconazole. M-holinoblokatory, slowing the emptying of the stomach, strengthen and lengthen the action of the drug.
    Special instructions:When using the drug Antareit and other medicines simultaneously, you should adhere to the interval of at least 1-2 hours. With long-term admission should ensure sufficient supply of phosphorus with food. With mild and moderate renal dysfunction, regular monitoring of the content of aluminum, calcium, phosphates in the blood plasma is necessary. The preparation contains sorbitol, which is contraindicated in congenital intolerance to fructose.
    Effect on the ability to drive transp. cf. and fur:Does not have a negative impact on the ability to drive vehicles and work with mechanisms that require increased concentration and speed of psychomotor reactions.
    Form release / dosage:Tablets chewing 400/20 mg and 800/40 mg.
    Packaging:For 6 tablets in a blister of G1VX / A1 foil.For 2 or 4 blisters together with instructions for use in a cardboard box.
    Storage conditions:

    In dry, dark place at a temperature of no higher than 25 ° C.

    Keep out of the reach of children.

    Shelf life:

    3 years.

    Do not use after the expiration date printed on the package.

    Terms of leave from pharmacies:Without recipe
    Registration number:LP-001887
    Date of registration:24.10.2012
    Expiration Date:24.10.2017
    The owner of the registration certificate:REMEDIYA, LLC REMEDIYA, LLC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp05.09.2017
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