Aspirin - instructions for use, dose, side effects, contraindications

Description:Round, slightly biconcave, beveled to the edge of a tablet of white color, with an imprint in the form of a brand name ("Bayer's" cross) on the one hand, and "ASPIRIN 0.5 "with a negotiable one.

Pharmacotherapeutic group:Non-steroidal anti-inflammatory drug (NSAID)

ATX: & nbsp

N.02.B.A Salicylic acid and its derivatives

Pharmacodynamics:

Acetylsalicylic acid (ASA) belongs to the group of non-steroidal anti-inflammatory drugs (NSAIDs) and has analgesic, antipyretic and anti-inflammatory effect, which is due to the inhibition of cyclooxygenase enzymes involved in the synthesis of prostaglandins.

ASA in the dose range from 0.3 to 1.0 g is used to reduce the temperature in diseases such as cold and flu, and to alleviate joint and muscle pain.

ASA inhibits platelet aggregation by blocking the synthesis of thromboxane A₂ in thrombocytes.

Indications:

- For symptomatic relief of headache, toothache, sore throat, pain during menstruation, pain in muscles and joints, back pain.

- The raised temperature of a body at cold and other infectious-inflammatory diseases (at adults and children is more senior 15 years).

Contraindications:

- Increased sensitivity to ASA, other NSAIDs or any excipients of the drug.

- Erosive-ulcerative lesions of the gastrointestinal tract (in the phase of exacerbation).

- Hemorrhagic diathesis.

- Bronchial asthma induced by the intake of salicylates and other NSAIDs.

- Combined use with methotrexate at a dose of 15 mg per week or more.

- I and III trimester of pregnancy and the period of breastfeeding.

The drug is not prescribed for children under 15 with acute respiratory infections caused by viral infections, because of the risk of developing Reye syndrome (encephalopathy and acute fatty liver disease with acute development of liver failure).

Carefully:With concomitant treatment with anticoagulants, gout, hyperuricemia, peptic ulcer and / or duodenal ulcer (in the anamnesis),including chronic or recurrent ulcer disease, as well as gastrointestinal bleeding; bronchial asthma, polyposis of the nose, chronic bronchopulmonary diseases; if the kidney and / or liver function is impaired; in IIth trimester of pregnancy.

Pregnancy and lactation:

If you need to use the drug during lactation, breastfeeding should be discontinued.

Dosing and Administration:

The drug is intended for adults and children over 15 years of age: In pain syndrome of mild and moderate intensity and fever, a single dose is 0.5-1 g, the maximum single dose is 1 g. The intervals between doses of the drug should be at least 4 hours. The maximum daily dose should not exceed 3 g (6 tablets).

How to use: take in, after eating, squeezed a lot of liquid.

The duration of treatment (without consulting a doctor) should not exceed 7 days when prescribed as an anesthetic and more than 3 days - as an antipyretic.

Side effects:

Gastrointestinal tract: abdominal pain, nausea, vomiting, heartburn, obvious (vomiting with blood,tarry stools) or latent signs of gastrointestinal bleeding, which can lead to iron deficiency anemia, erosive-ulcerative lesions (in including with perforation) of the gastrointestinal tract, an increase in the activity of "liver" enzymes.

central nervous system: dizziness and tinnitus (usually are signs of an overdose).

The system of hematopoiesis: increased risk of bleeding.

Allergic reactions: urticaria, anaphylactic reactions, bronchospasm, Quincke edema.

Overdose:

Symptoms

For an average overdose characteristic nausea, vomiting, tinnitus, hearing impairment, headache, dizziness and confusion.

These symptoms occur with a decrease in the dose of the drug.

For an overdose of severe severity are characteristic fever, hyperventilation, ketosis, respiratory alkalosis, metabolic acidosis, coma, cardiogenic shock, respiratory failure, severe hypoglycemia.

Treatment

Hospitalization, lavage, reception of activated charcoal, control of acid-base balance, alkaline diuresis for obtaining pH values of urine within the range of 7.5-8.0 (forced alkaline diuresis is considered achieved,when the concentration of salicylate in the blood is more than 500 mg / l (3.6 mmol / l) in adults and 300 mg / l (2.2 mmol / l) in children, hemodialysis, fluid loss compensation, symptomatic therapy.

Interaction:

Acetylsalicylic acid increases the toxicity of methotrexate, the effects of narcotic analgesics, other NSAIDs, hypoglycemic agents for ingestion, heparin, indirect anticoagulants, thrombolytic agents - platelet aggregation inhibitors, sulfonamides (including co-trimoxazole), triiodothyronine; reduces - uricosuric drugs (benzbromarone, probenecid), antihypertensive drugs and diuretics (spironolactone, furosemide).

Glucocorticosteroids, alcohol and ethanol containing drugs increase the damaging effect on the mucous membrane of the gastrointestinal tract, increase the risk of developing gastrointestinal bleeding.

Acetylsalicylic acid increases the concentration of digoxin, barbiturates and lithium preparations in blood plasma.

Antatsida, containing magnesium and / or aluminum hydroxide, slow down and worsen the absorption of acetylsalicylic acid.

Special instructions:

Children under 15 years of age should not be prescribed a drug containing acetylsalicylic acid,because in the case of a viral infection, the risk of developing Reye syndrome increases. Acetylsalicylic acid can cause bronchospasm, an attack of bronchial asthma or other reactions of hypersensitivity. Risk factors are the presence of a history of bronchial asthma, fever, polyps of the nose, chronic bronchopulmonary diseases, cases of an allergy in the history (allergic rhinitis, skin rashes). Acetylsalicylic acid can increase the tendency to bleeding, which is due to its inhibitory effect on platelet aggregation. This should be considered when surgical intervention is necessary, including minor interventions such as tooth extraction. Before surgical intervention, to reduce bleeding during surgery and in the postoperative period, it is necessary to cancel the drug for 5-7 days and inform the doctor.

Acetylsalicylic acid reduces the excretion of uric acid from the body, which can cause an acute attack of gout in predisposed patients.

Effect on the ability to drive transp. cf. and fur:

Does not affect.

Form release / dosage:Tablets 500 mg.

Packaging:

For 10 tablets in a blister of PVC / aluminum foil.

1, 2 or 10 blisters together with instructions for use in a cardboard bundle.

Storage conditions:

Store at a temperature not exceeding 30 ° C, out of the reach of children.

Shelf life:

5 years. Do not use after the time specified on the package.

Terms of leave from pharmacies:Without recipe

Registration number:П N013664 / 01

Date of registration:13.12.2007

Expiration Date:Unlimited

The owner of the registration certificate:Bayer Konsyumer Kare AGBayer Konsyumer Kare AG Switzerland

Manufacturer: & nbsp

BAYER BITTERFELD, GmbH Germany

Representation: & nbspBAYER, AOBAYER, AO

Information update date: & nbsp27.09.2017

Illustrated instructions

Instructions

Aspirin® (Aspirin®)