The frequency of side effects is shown in accordance with the following scale:
very frequent - 1/10 appointments (> 10%);
frequent - 1/100 appointments (> 1% and <10%);
infrequent - 1/1000 appointments (> 0.1% and <1%);
rare 1/10 000 prescriptions (> 0.01% and <0.1%);
very rare - 1/10 000 (<0.01%).
From the gastrointestinal tract:
Rarely: nausea, vomiting, epigastric pain, diarrhea (diarrhea), gastrointestinal bleeding (vomiting like "coffee grounds", black "tarry" stool); decreased appetite, increased activity of "liver" transaminases, ulcer and perforation of the stomach;
From the nervous system:
Rarely: headache, dizziness, decreased severity of hearing, ringing in the ears.
From the side of the blood and lymphatic system:
Rarely: hemorrhagic syndrome (epistaxis, bleeding gums, hemorrhagic rash), increased coagulation time. These effects persist for 4-8 days after discontinuation of the drug and should be taken into account in planning subsequent operations for patients.
From the immune system:
Rarely: skin rash, bronchospasm, angioedema. Formation on the basis of the hapten mechanism of the "aspirin" triad (combination of bronchial asthma, recurrent nasal polyposis and paranasal sinuses, and intolerance to acetylsalicylic acid and pyrazolone preparations);
From the liver and bile ducts:
Very rarely: Reye's syndrome (encephalopathy and acute fatty liver dystrophy with acute development of liver failure).
If any of the side effects indicated in the manual are aggravated, or if you notice any other side effects not listed in the instructions, stop taking the medication immediately and inform the doctor about it.