Acetylsalicylic acid - instructions for use, dose, side effects, contraindications

Has anti-inflammatory, antiplatelet and antipyretic effect associated with the suppression of cyclooxygenase 1 and 2, regulating the synthesis of prostaglandins. Reduces aggregation, aplatelet adhesiveness and thrombus formation by suppressing the synthesis of thromboxane A2 in platelets. Antiaggregation effect remains for 7 days after a single dose (more pronounced in men than in women).

Indications:

Moderately or mildly expressed pain syndrome in adults of different origins (headache, toothache, back and muscle pain, joint pain, menstruation pain).

Increased body temperature with colds and other Infectious-inflammatory diseases (in adults and children, over 15 years).

Contraindications:

- Hypersensitivity to acetylsalicylic acids and other NSAIDs or other components of the drug;

- erosive and ulcerative lesions of the gastrointestinal tract (in the phase of exacerbation);

- hemorrhagic diathesis;

- combined use of methotrexate in a dose of 15 mg per week or more;

- asthma caused by taking salicylates or other NSAIDs;

- pregnancy (I and III trimester), the period of breastfeeding.

A drug Do not prescribe to children under 15 years of age with acute respiratory infections, caused by viral infections because of the risk of developing Reye syndrome (encephalopathy and acute fatty liver dystrophy with acute development of hepatic insufficiency).

Carefully:With concomitant therapy with anticoagulants, gout, peptic ulcer and / or duodenal ulcer (in the anamnesis),including chronic or recurrent ulcer disease, or episodes of gastrointestinal bleeding; renal and / or hepatic insufficiency, deficiency of glucose-6-phosphate dehydrogenase.

Dosing and Administration:

In pain syndrome of mild and moderate intensity and fever, a single dose is 0.5-1 g, the maximum single dose -1 g, the maximum daily dose should not exceed 3 g. The intervals between doses of the drug should be at least 4 hours. To reduce the irritant effect on the gastrointestinal tract, the drug should be accept after eating, drinking water, milk, alkaline mineral water.

Duration of treatment (without consulting a doctor) should not exceed 5 days at appointment as an anesthetic and not more than 3 days - as an antipyretic agent.

Side effects:

From the gastrointestinal tract: pain in the abdomen, heartburn. nausea, vomiting, obvious (vomiting with blood, tarry stools) or hidden signs of gastrointestinal bleeding, which can lead to iron deficiency anemia, erosive and ulcerative lesions (including perforation) of the gastrointestinal tract, isolated cases - violations of liver function (increased hepatic transaminases).

From the central nervous system: dizziness, tinnitus (usually are signs of an overdose).

On the part of the hematopoiesis system: increased risk of bleeding, which is a consequence of the effect of acetylsalicylic acid on the platelet aggregation.

Allergic reactions: skin rash, anaphylactic reactions, bronchospasm, angioedema.

When such symptoms appear, it is recommended to stop taking the drug and immediately consult a doctor.

Overdose:

Symptoms

Overdose of moderate severity: nausea, vomiting, tinnitus, hearing impairment, headache, dizziness and confusion. These symptoms occur with a decrease in the dose of the drug.

Severe overdose: fever, hyperventilation, ketosis, respiratory alkalosis, metabolic acidosis, coma, cardiogenic shock, respiratory failure, severe hypoglycemia.

Treatment: hospitalization, lavage, reception of activated charcoal, monitoring of acid-base balance, alkaline diuresis in order to obtain a pH of urine between 7.5-8 (forced alkaline diuresis is considered achieved,if the concentration of salicylate in the blood plasma is more than 500 mg / l (3.6 mmol / l) in adults or 300 mg / l (2.2 mmol / l) in children), hemodialysis, fluid loss compensation, symptomatic therapy.

Interaction:

Acetylsalicylic acid increases the toxicity of methotrexate, the effects of narcotic analgesics, other NSAIDs, oral hypoglycemic drugs, heparin, indirect anticoagulants, thrombolytic agents and platelet aggregation inhibitors, sulfonamides (including co-trimoxazole, triiodothyronine, reduces uricosuric drugs (benzbromarone, sulfinpyrazone, antihypertensive drugs and diuretics (spironolactone, furosemide).

Glucocorticosteroids, alcohol and alcohol-containing preparations increase the damaging effect on the gastrointestinal mucosa, increase the risk of developing gastrointestinal bleeding.

Acetylsalicylic acid increases the concentration of digoxin, barbiturates and lithium preparations in blood plasma.

Antacids containing magnesium and / or aluminum hydroxide, slow down and worsen absorption acetylsalicylic acid.

Special instructions:

Acetylsalicylic acid can cause bronchospasm, an attack of bronchial asthma or other hypersensitivity reactions. Risk factors are the presence of bronchial asthma, polyps of the nose, fever, chronic bronchopulmonary diseases, cases of allergy in the anamnesis (allergic rhinitis, skin rashes).

Acetylsalicylic acid can increase the tendency to bleeding, which is due to its inhibitory effect on platelet aggregation. This should be taken into account when necessary surgical interventions, including such minor interventions as tooth extraction. Before surgical intervention, to reduce bleeding during surgery and in the postoperative period, you should cancel taking the drug for 5-7 days and inform the doctor.

Children should not be prescribed drugs containing acetylsalicylic acid, because in the case of a viral infection, the risk of developing Reye syndrome increases.

Symptoms of the syndrome Rey are prolonged vomiting, acute encephalopathy, enlargement of the liver.

If you need to use the drug during lactation, breastfeeding should be discontinued.

Acetylsalicylic acid reduces the excretion of uric acid from the body, which can cause an acute attack of padahry in predisposed patients.

Effect on the ability to drive transp. cf. and fur:There was no evidence of the effect of drug administration on vehicle management and other mechanisms.

Form release / dosage:Tablets of 500 mg.

Packaging:For 10 tablets in a contour cell or cellulose package. 2 or 3 contour mesh packages together with the instruction for use are placed in a pack of cardboard. Contour mesh and cellless containers are allowed with an equal number of instructions for use in a cardboard box.

Storage conditions:In dry, dark place at a temperature of no higher than 25 FROM. Keep out of the reach of children!

Shelf life:4 years. Do not use after the time specified on the package.

Terms of leave from pharmacies:Without recipe

Registration number:LS-002687

Date of registration:13.12.2011

Expiration Date:Unlimited

The owner of the registration certificate:MARBIOFARM, OJSC MARBIOFARM, OJSC Russia

Manufacturer: & nbsp

MARBIOFARM, OJSC Russia

Information update date: & nbsp02.10.2017

Illustrated instructions

Instructions

Acetylsalicylic acid (Acetylsalicylic acid)