Intravenously, infusion.
The dose is set individually and depends on the necessary duration and depth of the neuromuscular blockade.
Adults
- Bolus administration.
To provide muscular relaxation within 15-35 minutes 0.3-0.6 mg / kg is administered. The dose for intubation of the trachea is 0.5-0.6 mg / kg. The duration of complete neuromuscular blockade can be increased by introducing additional doses at the rate of 0.1-0.2 mg / kg.
- Infusion introduction.
After bolus administration, it is possible to administer the drug as a continuous infusion at a rate of about,3-0.6 mg / kg / hour to maintain neuromuscular blockade during long-term surgical interventions. This method of administration can be recommended for operations on the lungs and the heart. To maintain complete myoplegia with artificial hypothermia, the infusion rate should be reduced by a factor of 2.
Atrakurium-Medargo is compatible with the following infusion solutions:
| Infusion solution | Stability period |
| A solution of sodium chloride 0.9% | 24 hours |
| A solution of dextrose 5% | 8 ocloc'k |
| Ringer's solution | 8 ocloc'k |
| A solution of sodium chloride 0.18% + dextrose 4% | 8 ocloc'k |
| Hartmann's solution | 4 hours |
Children.
Children over 1 month are prescribed in the same dosages (based on body weight) as adults.
The elderly.
Dose adjustment is not required, however, it is recommended to use the lower level of the dose range.
Impaired liver and / or kidney function.
A dose adjustment is not required.
Diseases of the cardiovascular system.
In patients with severe cardiovascular pathology, the initial dose should be administered at least 60 seconds.
Application in intensive care units.
After initial bolus administration at a dose of 0.3-0.6 mg / kg, administered by continuous infusion at a rate of 0.65-0.78 mg / kg / h, however, in different patients, a dose variation of 0.27 mg / kg / hour up to 1.77 mg / kg / hour.
After the initial bolus dose, drip continuous infusion can be used to maintain the required degree of neuromuscular blockade at a rate of 6-10 μg / kg / min. The exact dosage during infusion is provided by the use of a special metered micropump. When the body is hypothermic, complete neuromuscular blockade is maintained at doses equal to half the usual dose.
The dose in children 1-24 months - 0.3-0.4 mg / kg, over 2 years - as in adults.
Doses for children younger than 1 month - doses not established. For elderly patients, they recommend use the lowest recommended dose with reduced injection rate - 60 sec.