Benzyldimethyl [3- (myristoylamino) propyl] ammonium chloride monohydrate - instructions for use, dose, side effects, contraindications

Selectively inhibits the enzymatic system of microorganisms, immersed in hydrophobic areas of membranes, increasing their permeability, which culminates. By loosening the membranes of microorganisms, enhances the effects of antibacterial agents.

It does not interact with the membranes of human cells, which contain lipids of a much longer length, which excludes hydrophobic interaction with the drug.

Has bactericidal activity against gram-positive (streptococci, staphylococcus and others) and Gram-negative (Pseudomonas aeruginosa, E. coli, Klebsiella, Proteus and others) bacteria. Active with respect to virus Herpes simplex type 2, Neisseria gonorrhoeae, Staphylococcus aureus, Chlamydia spp., Trichomonas vaginalis, Gardnerella vaginalis, Haemophilus ducreyi, Treponema pallidum and Candida albicans.

Pharmacokinetics:

The drug for topical application does not have a systemic effect.

Indications:

It is used for the treatment of infectious and inflammatory diseases of the oral cavity and pharynx, dermatomycosis and pyoderma, inflammatory diseases of female genital organs. Used in the complex therapy for diseases of the ENT organs and organs of the urethra. It is used for the prevention of sexually transmitted infections, secondary infection of wounds. Used to treat wounds, drainage of bone cavities in osteomyelitis. It is used for the treatment of superficial thermal burns, long-term non-healing wounds of soft tissues, including in the postpartum period. Used in ophthalmology for the treatment and prevention of infectious and inflammatory eye diseases.

ICD-10

I.A50-A64.A52 Late syphilis

I.A50-A64.A51 Early syphilis

I.A50-A64.A54 Gonococcal infection

I.A50-A64.A54.3 Gonococcal infection of the eye

I.A50-A64.A56.0 Chlamydial infections of the lower parts of the genito-urinary tract

I.A50-A64.A56.1 Chlamydial infections of the pelvic organs and other urogenital organs

I.A50-A64.A56.4 Chlamydial pharyngitis

I.A50-A64.A59 Trichomoniasis

I.A50-A64.A60 Anogenital herpetic viral infection [herpes simplex]

I.B35-B49.B35.4 Mycosis of the trunk

I.B35-B49.B35.3 Mycosis of the feet

I.B35-B49.B35.2 Mycosis brushes

I.B35-B49.B37.4 Candidiasis of other urogenital localizations

I.B35-B49.B37.3 Candidiasis of the vulva and vagina (N77.1 *)

I.B35-B49.B37.2 Candidiasis of skin and nails

I.B35-B49.B37.0 Candidiasis stomatitis

VIII.H60-H62.H60 External otitis media

VIII.H60-H62.H62.2 * External otitis with fungal infections

VIII.H65-H75.H66 Purulent and unspecified otitis media

X.J00-J06.J04 Acute laryngitis and tracheitis

X.J30-J39.J32 Chronic Sinusitis

X.J00-J06.J01 Acute Sinusitis

X.J30-J39.J31 Chronic rhinitis, nasopharyngitis and pharyngitis

X.J30-J39.J35.0 Chronic tonsillitis

X.J00-J06.J03 Acute tonsillitis

X.J30-J39.J37 Chronic laryngitis and laryngotracheitis

XI.K00-K14.K04 Diseases of pulp and periapical tissues

XI.K00-K14.K05 Gingivitis and periodontal disease

XI.K00-K14.K05.1 Chronic gingivitis

XI.K00-K14.K05.0 Acute gingivitis

XI.K00-K14.K12 Stomatitis and related lesions

XII.L00-L08.L08.0 Pyoderma

XIII.M00-M03.M00 Pyogenic arthritis

XIII.M86-M90.M86 Osteomyelitis

XIV.N30-N39.N34 Urethritis and urethral syndrome

XIV.N40-N51.N41 Inflammatory diseases of the prostate

XIV.N70-N77.N72 Inflammatory disease of the cervix

XIV.N70-N77.N76 Other inflammatory diseases of the vagina and vulva

XV.O20-O29.O23.5 Infections of the genital tract during pregnancy

XV.O85-O92.O86.1 Other genital tract infections after childbirth

XIX.T20-T32.T30 Thermal and chemical burns, unspecified

XIX.T79.T79.3 Post-traumatic wound infection, not elsewhere classified

Contraindications:

Malignant neoplasms of the skin and mucous membranes, individual intolerance, children under 3 years old.

Carefully:

Hypersensitivity.

Pregnancy and lactation:

Recommendations for FDA - Category B. Does not have a systemic effect, is used during pregnancy.

Dosing and Administration:

Use in children

For the treatment of acute pharyngitis or exacerbation of chronic tonsillitis, irrigation of the pharynx is carried out with a spray nozzle:

3-6 years - 3-4 times a day for 3-5 ml (one irrigation);

7-14 years - 3-4 times a day for 5-7 ml (two irrigation);

Over 14 years - 3-4 times a day for 10-15 ml (3-4 irrigation).

Adults

Rinsing of the oral cavity: 3-4 times a day for 10-15 ml.

Injection spray nozzle with laryngitis, pharyngitis and tonsillitis: 3-4 times a day for 4-5 irrigation (15-20 ml).

Active drainage of wounds: 1 liter per day.

In order to treat wounds and burns, the affected surface is washed, then a tissue moistened with the drug is applied, then it is fixed with a band-aid or bandage.

In order to prevent sexually transmitted diseases,within 2 hours after sexual intercourse, the solution is instilled into the urethra and vagina, and the inner surfaces of the thighs are also treated.

In the complex treatment of urethritis: instillation in the urethra 1-2 times a day for 2-3 ml.

In obstetrics: vaginal irrigation for 5-7 days before delivery, after each vaginal examination in childbirth, in the postpartum period - 50 ml on a tampon for 2 hours.

Eye drops: for treatment - instillation in the conjunctival sac 1-2 drops 4-6 times a day; with the purpose of prevention - 1-2 drops 3 times a day for 2-3 days before surgery and within 2 weeks after the operation.

Side effects:

Dermatological reactions: dermatitis, dry skin, itching.

Allergic reactions.

Overdose:

Cases of overdose are not described.

Treatment is symptomatic.

Interaction:

Enhances the effects of antibacterial and antifungal agents.

Special instructions:

After using the drug for the prevention of sexually transmitted diseases, urination is not recommended for 2 hours.

Instructions

Benzyldimethyl [3- (myristoylamino) propyl] ammonium chloride monohydrate (Benzyldimethyl-myristoilamine-propylammonium chloride monohydrate)