Miramistin® (Miramistin®)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceBenzyldimethyl [3- (myristoylamino) propyl] ammonium chloride monohydrateBenzyldimethyl [3- (myristoylamino) propyl] ammonium chloride monohydrate
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    • Dosage form: & nbsptopical solution
    Composition:

    Active substance:

    Benzyldimethyl [3- (myristoyl-amino) propyl] ammonium chloride monohydrate

    (in terms of anhydrous substance) - 0.1 g

    auxiliary substance: purified water - up to 1 liter.

    Description:Colorless, clear liquid, foaming with shaking.
    Pharmacotherapeutic group:Antiseptic
    ATX: & nbsp

    D.08.A.J   Quaternary ammonium compounds

    S.01.A.X   Other antimicrobials

    Pharmacodynamics:

    Miramistine has a broad spectrum of antimicrobial activity, including hospital strains resistant to antibiotics. The drug has a pronounced bactericidal effect against Gram-positive (Staphylococcus spp., Streptococcus spp., Streptococcus pneumoniae and others), gram-negative (Pseudomonas aeruginosa, Escherichia coli, Klebsiella spp. and others), aerobic and anaerobic bacteria, defined as monocultures and microbial associations, including hospital strains with multidrug resistance to antibiotics. Has an antifungal effect on Ascomycetes of the genus Aspergillus and Penicillium, yeasts (Rhodotorula rubra, Torulopsis gabrata etc.), and yeast-like fungi (Candida albicans, Candida tropicalis, Candida , krusei, Pityrosporum orbiculare (Malassezia furfur) etc.), dermatophytes (Trychophyton rubrum, Trychophyton mentagrophytes, Trychophyton verrucosum, Trychophyton schoenleini, Trychophyton violacent, Epidermophyton Kaufman-Wolf, Epidermophyton . floccosum, Microsporum gypseiim, Microsporum canis etc.), as well as other pathogenic fungi, in the form of monocultures and microbial associations, including a fungal microflora with resistance to chemotherapeutic drugs. Has antiviral effect, is active against complex viruses (herpes viruses, human immunodeficiency virus, etc.) Miramistin acts on pathogens of sexually transmitted diseases (Chlamydia spp., Treponema spp., Trichomonas vaginalis, Neisseria gonorrhoeae and etc.). Effectively prevents infection of wounds and burns. Activates regeneration processes. Stimulates protective reactions at the site of application, by activating the absorbing and digesting function of phagocytes, potentiates the activity of the monocyte-macrophage system. Has a pronounced hyperosmolar activity, as a result of which it stops wound and perifocal inflammation, absorbs purulent exudate, contributing to the formation of a dry scab. Does not damage granulation and viable skin cells, does not inhibit marginal epithelization.

    Does not possess local irritating effect and allergic properties.

    Pharmacokinetics:With topical application miramistin does not have the ability to be absorbed through the skin and mucous membranes.
    Indications:

    Surgery, traumatology: prevention suppuration and treatment of purulent wounds. Treatment of purulent-inflammatory processes of the musculoskeletal system.

    Obstetrics, gynecology: prevention and treatment of suppuration of postpartum injuries, crotch and vagina wounds, postpartum infections, inflammatory diseases (vulvovaginitis, endometritis).

    Combustiology: treatment of superficial and deep burns II and IIIA degree, preparation of burn wounds to dermatoplasty.

    Dermatology, venereology: treatment and prevention of pyoderma and dermatomycosis, candidiasis skin and mucous membranes, foot mycoses.

    Individual prevention Sexually transmitted diseases (syphilis, gonorrhea, chlamydia, trichomoniasis, genital herpes, genital candidiasis, etc.).

    Urology: complex treatment of acute and chronic urethritis and urethroprostatitis specific (chlamydia, trichomoniasis, gonorrhea) and nonspecific nature.

    Stomatology: treatment and prevention of infectious and inflammatory diseases of the oral cavity: stomatitis, gingivitis, periodontitis, periodontitis. Hygienic treatment of removable dentures.

    Otorhinolaryngology: complex treatment of acute and chronic otitis, sinusitis, tonsillitis, laryngitis, pharyngitis.

    Children: at the age of 3 to 14 years is used for the complex treatment of acute pharyngitis and / or exacerbation of chronic tonsillitis.

    Contraindications:Individual intolerance to the drug.
    Dosing and Administration:

    The drug is ready for use.

    Notes on the use of a spray gun package:

    1. Remove the cap from the vial, remove the urologic applicator from the 50 ml vial.

    2. Remove the supplied nozzle from the protective packaging.

    3. Connect the spray nozzle to the vial.

    4. Press the nozzle again to activate the nozzle.

    Surgery, Traumatology, Combustiology.

    With a preventive and curative purpose irrigate the surface of wounds and burns, loose wounds and fistulous swabs are stuffed, gauze tampons moistened with the drug are fixed. The treatment procedure is repeated 2-3 times a day for 3-5 days.The method of active drainage of wounds and cavities with a daily consumption of up to 1 liter of the drug is highly effective.

    Obstetrics, gynecology.

    For the prevention of postpartum infection, it is used in the form of vaginal irrigation before childbirth (5-7 days), at birth after each vaginal examination and in the postpartum period 50 ml of the drug in the form of a tampon with an exposure of 2 hours for 5 days. With the delivery of women by caesarean section, just before the operation processes the vagina, during the operation - the uterine cavity and the incision on it, and in the postoperative period, tampons moistened with the drug are injected into the vagina with an exposure of 2 h for 7 days. Treatment of inflammatory diseases is carried out course for 2 weeks by intravaginal administration of tampons with the drug, as well as the drug electrophoresis method.

    Venerology.

    For the prevention of sexually transmitted diseases the drug is effective if it is used no later than 2 hours after sexual intercourse. The contents of the vial with Urological applicator to enter the urethra for 2-3 min: men (2-3 ml), women (1-2 ml) and in the vagina (5-10 ml). Treat the skin of the inner surfaces of the hips, pubic area, genitals.After the procedure, it is recommended not to urinate for 2 hours.

    Urology.

    In the complex treatment of urethritis and urethroprostatitis, 2-3 ml of the drug are injected into the urethra 1-2 times a day, the course is 10 days.

    Otorhinolaryngology.

    When purulent, sinusitis during puncture, the maxillary sinus is washed with a sufficient amount of the drug. Tonsillitis, pharyngitis and laryngitis are treated with rinsing, throat and / or irrigation with a spray nozzle, 3-4 times a day, 3-4 times a day. The amount of preparation per rinse is 10-15 ml.

    Children.

    In acute pharyngitis and / or exacerbation of chronic tonsillitis, irrigation of the pharynx is carried out with the help of a spray nozzle. Children aged 3-6 years: a single press on the head of the spray nozzle (3-5 ml per irrigation), 3-4 times a day; children aged 7-14 years with a double tap (5-7 ml per irrigation), 3-4 times a day; children over 14 years 3-4 times pressing (10-15 ml per irrigation) 3-4 times a day. The duration of therapy is from 4 to 10 days, depending on the timing of the onset of remission.

    Stomatology.

    With stomatitis, gingivitis, periodontitis, it is recommended to rinse the oral cavity 10-15 ml of the drug 3-4 times a day.

    Side effects:In some cases, at the site of application, a feeling of slight burning that can go away by itself, after 15-20 seconds, does not need to be canceled. Allergic reactions.
    Interaction:With simultaneous use with antibiotics, there has been an increase in their antibacterial and antifungal properties.
    Form release / dosage:

    Topical solution 0.01%.

    Packaging:

    Polyethylene bottles with a urological applicator with a screw cap 50 ml, 100 ml. Polyethylene bottles of 50 ml with an urological applicator with a screw cap, complete with a nozzle-sprayer.

    Polyethylene bottles 100 ml, 150 ml, 200 ml complete with a nozzle-sprayer or equipped with a spray pump and protective cap. Polyethylene bottles 500 ml with a screw cap with the control of the first opening.

    Each vial of 50 ml, 100 ml, 150 ml, 200 ml, 500 ml together with the instruction for use is placed in a cardboard box.

    For hospitals: 12 bottles of 500 ml without a bundle with an equal number of instructions for use are placed in a box of cardboard for consumer containers.

    Storage conditions:Store at a temperature not exceeding 25 ° C.

    Keep out of the reach of children.
    Shelf life:3 years. Do not use after the expiration date.
    Terms of leave from pharmacies:Without recipe
    Registration number:P N001926 / 01
    Date of registration:13.12.2007
    The owner of the registration certificate:INFAMED, LLC INFAMED, LLC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp24.11.2015
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