Betagistin acts mainly on histamine H1- and H3-receptors inner ear and vestibular CNS nuclei. By direct agonistic effects on H1receptors of the vessels of the inner ear, as well as indirectly through exposure to H3-receptors improves microcirculation and permeability of capillaries, normalizes the pressure of the endolymph in the labyrinth and cochlea. At the same time betagistin increases blood flow in the basilar artery.
Has a pronounced central effect, being an inhibitor H3receptors of the nuclei of the vestibular nerve. Improves conductivity in the neurons of the vestibular nuclei at the level of the brainstem.
The clinical manifestation of these properties is a decrease in the frequency and intensity of dizziness, a decrease in noise in the ears, and improvement in hearing in the event of a decrease in it.