Bifidumbacterin - instructions for use, dose, side effects, contraindications

Excipients: Witepsol H15 - 45,06-49,80%, Witepsol W35 - 45,06-49,80%, paraffin liquid (vaseline oil) - 4.75-5.25%, components of the drying medium (sucrose-gelatin): sucrose - 0.12-0.13%, gelatin - 0.01-0.02%.

Description:

Suppositories from white to yellowish-gray or light-beige, torpedo-shaped. One end of the suppository is rounded, the other end is smooth or with a funnel-like depression. The diameter is from 9.5 to 10.0 mm. It is allowed heterogeneity in the form of inclusions or marbling.

Pharmacotherapeutic group:Eubiotic

ATX: & nbsp

A.07.F.A Antidiarrhoeal preparations of biological origin regulating the balance of intestinal microflora

Pharmacodynamics:

Live bifidobacteria (Bifidobacterium bifidum) have a high antagonistic activity against a wide range of pathogenic and conditionally pathogenic microorganisms, including staphylococci, proteus, enteropathogenic and hemolytic coliforms, shigella, yeast-like fungi, which determines the normalizing effect of the drug for violations of the microbiocenosis of the intestine and vagina.

Antagonistic effects on pathogenic and conditionally pathogenic microflora contribute to the restoration of normal microflora.

Pharmacokinetics:

Not absorbed into the bloodstream.

Indications:

Treatment and prevention of dysbacteriosis and inflammatory processes of the distal intestine (adults and children from 3 years):

- chronic colitis of different etiology with the localization of the pathological process in the distal parts of the colon;

- dysbacteriosis of the intestine, including the restoration of intestinal microflora in patients who have had acute intestinal infections and antibacterial therapy.

Treatment and prevention of vaginal dysbiosis and inflammatory processes of female genitalia (adults)

- nonspecific vaginitis (colpitis), not gonococcal and trichomonas etiology; dysbiosis of the vagina, including bacterial vaginosis (gardnerellez); candidiasis of the vagina - to restore normal microflora after the termination of a specific antimicrobial, antiviral or antifungal therapy, as a mono drug or in combination with immunomodulating medications;

- subacute and chronic stages of inflammatory processes of the female sexual sphere; appoint after the end of the course of antibiotic therapy in order to normalize the microflora;

- hormone-dependent colpitis (vaginitis), including senile; appoint on a background of hormone replacement therapy;

- preparation for planned gynecological operations to prevent postoperative infectious complications;

- prenatal preparation of pregnant women at risk for developing inflammatory diseases with a violation of the purity of the vaginal secretion III-IV degree for the purpose of prevention and treatment of vaginal dysbiosis;

- in the complex treatment of urogenital infections and other sexually transmitted diseases (STDs): gonorrhea, urogenital chlamydiosis, urogenital herpes.

Contraindications:

Not established, except for individual intolerance of the drug.

Pregnancy and lactation:

Bifidobacteria are representatives of normal human microflora. Preparations made on their basis, can be used during pregnancy and breastfeeding. There are no special reception conditions.

Dosing and Administration:

With intestinal diseases (children over 3 years and adults)

Suppositories are used rectally 3 times a day for 1-2 suppositories on reception simultaneously with reception of oral forms of preparations with the group name bifidobacteria bifidum. Duration of treatment: after acute intestinal infections is 7-10 days, with prolonged and chronic forms of the disease, intestinal dysbiosis 15-30 days or more.

When a hemolytic coliform is detected (E.coli enterohemorrhagic) the drug is administered 1 suppository 1-2 times a day for 10 days.

If necessary, treatment courses can be repeated after 3-4 months.

For reconstructive therapy with antibacterial drugs and the prevention of colitis, the drug is administered 1 suppository 1-2 times a day for 10 days. If necessary, the course of treatment can be repeated after 10-20 days.

In gynecological practice (adults)

Nonspecific colpitis (vaginitis), including senile vaginitis of hormonal nature, vaginal dysbiosis and others: prescribe vaginally 1 suppository 2 times a day for 5-10 days.

When the purity of vaginal secretion in pregnant women is violated III-IV degree of the drug is used for 1 suppository 1-2 times a day for 5-10 and more days under the control of the restoration of purity of the vaginal secretion to I-II degree and disappearance of clinical symptoms.

In order to prevent purulent-septic complications with planned gynecological operations, one suppository is used 1-2 times a day for 5-10 days before and 10 days after surgery or delivery.

In the complex treatment of urogenital infections and other STDs, the drug is applied to 1 suppository 3 times a day, the course of treatment is 15 days.

Restorative therapy after the application of antibiotics: the drug is administered to 1 suppository 1-2 times a day for 10 days.

Prior to application, the cell packaging is cut.

Side effects:

Perhaps the development of allergic reactions.

Overdose:

Cases of overdose were not observed.

Interaction:

Bifidumbacterin, rectal and vaginal suppositories, can be used simultaneously with antiviral and immunomodulating medications in accordance with their prescriptions and age-related doses. The recommended interval between taking antibacterial drugs and applying Bifidumbacterin, suppositories rectal and vaginal, is 3-4 hours.

It is recommended simultaneous use of suppositories and oral forms of bifid-containing drugs with a group name bifidobacteria bifidum (Bifidumbacterin, powder for ingestion and topical application, Bifidumbacterin forte, Probi®).

Effect on the ability to drive transp. cf. and fur:

The drug does not affect the ability to drive vehicles, mechanisms.

Form release / dosage:Suppositories rectal and vaginal.

Packaging:

5 suppositories (5 doses) in a contour cell box made of polymer materials.

2 contour squares in a pack of cardboard together with instructions for use.

Storage conditions:

Store at a temperature of 2 to 10 ° C.

Keep out of the reach of children.

Shelf life:

1 year.

The drug is not suitable for use after the expiry date, with a change in appearance, in the absence or fuzzy marking on the primary packaging, if the primary packaging fails to seal.

Terms of leave from pharmacies:Without recipe

Registration number:LP-002464

Date of registration:13.05.2014

Expiration Date:13.05.2019

The owner of the registration certificate:PARTNER, CJSC PARTNER, CJSC Russia

Manufacturer: & nbsp

PARTNER, CJSC Russia

Representation: & nbspPARTNER CJSC PARTNER CJSC Russia

Information update date: & nbsp14.02.2017

Illustrated instructions

Instructions

Bifidumbacterin (Bifidumbacterin)