Active substanceHyaluronidaseHyaluronidase
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  • Biogial
    lyophilizate locally externally 
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  • Lidase-M
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  • Dosage form: & nbsplyophilizate for solution preparation for local and external use
    Composition:

    One bottle contains:

    active substance: hyaluronidase 300 ME;

    Excipients: mannitol 127 mg.

    Description:

    White with a yellowish tinge to a light brown powder or a porous mass with a characteristic odor. The preparation is hygroscopic.

    Pharmacotherapeutic group:Enzyme agent
    ATX: & nbsp

    V.03.A.X   Other medications

    Pharmacodynamics:

    Biogial is an enzyme preparation containing the enzyme hyaluronidase, produced by a strain of microorganisms Streptomyces actinocidus 77. Splits the main component of interstitial substance of connective tissue - hyaluronic acid (mucopolysaccharide, is a cementing substance of connective tissue) - to glucosamine and glucuronic acid and thereby reduces its viscosity, increases tissue and vascular permeability,facilitates the movement of liquids in interstitial spaces; reduces puffiness of the tissue, softens and flattens the scars, increases the amount of movement in the joints, reduces contractures and prevents their formation.

    Indications:

    Burn, traumatic, postoperative scars; stiffness of joints, joint contractures (after inflammatory processes and traumas); osteoarthritis; chronic tendovaginitis; Functional disability after postponed inflammatory processes of female genital organs (hypoecretion of the vaginal mucosa, insufficient elasticity of its walls, etc.); cutaneous manifestations of scleroderma; hematomas of soft tissues of surface localization; preparation for kozhnoplasticheskim operations, reconstructive and plastic operations on female genital organs to prevent scar deformities.

    Contraindications:

    Hypersensitivity to the components of the drug, acute inflammatory processes, infectious diseases, malignant neoplasms, pregnancy, the period of breastfeeding, children under 18 years.

    Dosing and Administration:

    Outer and local.The biogial is used in the form of bandages, by electrophoresis and in the form of intravaginal tampons.

    In the form of dressings, impregnated with the solution of the preparation. To prepare the solution, the contents of the vial (300 IU) are dissolved in 5-10 ml (30-60 IU / ml) sterile 0.9% sodium chloride solution or distilled water. This solution is moistened with a sterile gauze napkin folded in 4-5 layers, it is applied to the affected area, covered with wax paper and fixed with a soft bandage.

    The dose depends on the area of ​​the lesion and ranges from 30 to 60 ME on 1 sq. cm of surface, on the average - 300 ME on the bandage. The dressing is applied daily for 15-18 hours for 15-60 days. With long-term use every 2 weeks make a break for 3-4 days.

    When applying by electrophoresis the contents of the bottle (300 ME) is dissolved in 60 ml of distilled water, 2-3 drops of 0.1% hydrochloric acid are added and injected from the anode onto the affected area for 20-30 minutes. The course of treatment - 15-20 sessions. The prepared solution should be used within 24 hours. Application dosage can be alternated with electrophoresis.

    When intravaginal administration the contents of the bottle (300 ME) is dissolved in 5-10 ml (30-60 IU / ml) sterile 0.9% solution of sodium chloride, the resulting solution is moistened with a sterile swab that is injected into the vagina daily for 5-6 hours for 10-14 days.

    Side effects:

    Allergic reactions, with prolonged use - local skin reactions (dermatitis).

    Overdose:

    Data on drug overdose are absent.

    Interaction:

    When using Biogial in patients receiving salicylates, cortisone, ACTH, estrogens or antihistamines in high doses, the effectiveness of the action of the enzyme hyaluronidase can be reduced.

    When prescribing the drug in combination with other drugs, one should consider the possibility of increasing their absorption (bioavailability) and enhancing systemic action.

    Special instructions:

    When used against the background of acute foci of infection to prevent the spread of infection, prescribe the drug in combination with antimicrobial therapy.

    When developing an allergic reaction, immediately stop using the drug and consult a doctor.

    The drug should be used in the early stages of the disease and as part of complex therapy (therapeutic exercises, massage,anti-inflammatory, analgesic and other methods of treatment).

    Effect on the ability to drive transp. cf. and fur:

    The use of the drug does not affect the ability to drive vehicles and engage in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

    Form release / dosage:Liofilizate for solution for local and external use, 300 ME.
    Packaging:

    To 300 ME in bottles with a capacity of 10 ml of neutral glass, corked with rubber stoppers and aluminum caps.

    Vials are labeled with label paper or writing paper.

    10 bottles together with the instruction for use will be prevented in boxes made of cardboard box.

    Storage conditions:

    In the dark place at a temperature of 2 to 8 FROM.

    Keep out of the reach of children.

    Shelf life:

    2 years.

    Do not use after expiry date.

    Terms of leave from pharmacies:On prescription
    Registration number:LP-003143
    Date of registration:18.08.2015 / 27.12.2016
    Expiration Date:18.08.2020
    The owner of the registration certificate:Biona, Open CompanyBiona, Open Company Russia
    Manufacturer: & nbsp
    Information update date: & nbsp12.02.2017
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