Active substanceHyaluronidaseHyaluronidase
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  • Dosage form: & nbsplyophilizate for solution for injection and topical application
    Composition:

    1 bottle contains:

    Active substance: hyaluronidase 64 UE.

    Description:

    Lyophilized powder or porous mass, compacted into a tablet, white or white with a yellowish, pinkish, beige, cream or brownish hue.

    Pharmacotherapeutic group:Enzyme agent
    ATX: & nbsp

    V.03.A.X   Other medications

    Pharmacodynamics:

    Enzyme preparation isolated from testes of cattle.

    Splits the main component of interstitial substance of connective tissue - hyaluronic acid (mucopolysaccharide, which includes acetylglucosamine and glucuronic acid, is a cementing substance of connective tissue), reduces its viscosity, increases tissue and vascular permeability,facilitates the movement of liquids in interstitial spaces; reduces puffiness of the tissue, softens and flattens the scars, increases the amount of movement in the joints, reduces contractures and prevents their formation. Hyaluronidase causes the decomposition of hyaluronic acid to glucosamine and glucuronic acid and thereby reduces its viscosity.

    Duration of action for intradermal administration is up to 48 h.

    Indications:

    Burn, traumatic, postoperative scars; long-term non-healing ulcers (including radiation ulcers); Dupuytren's contracture; stiffness of the joints, joint contractures (after inflammation, trauma), osteoarthritis, ankylosing spondylitis, severe lumbar disc disease; chronic tenosynovitis, scleroderma (skin manifestations), soft tissue hematoma of surface localization; preparation for skin and plastic surgery for scarring.

    Tuberculosis of the lungs (complicated by nonspecific lesions of the bronchi), inflammatory processes in the upper respiratory tract and bronchial tubes with obstruction phenomena.

    Traumatic lesions of nerve plexuses and peripheral nerves (plexitis, neuritis).

    Hyphema, hemophthalmus, retinopathy of various etiologies.

    Contraindications:

    Hypersensitivity, acute infectious and inflammatory diseases, recent hemorrhages, acute intercurrent diseases, children under 18 years.

    For inhalation, pulmonary tuberculosis with severe respiratory failure; pulmonary hemorrhage, hemoptysis; malignant neoplasms, fresh vitreous hemorrhage.

    Concomitant reception of estrogens.

    Carefully:

    Pregnancy, lactation.

    Dosing and Administration:

    With cicatricial lesions subcutaneously (under scar tissue) or intramuscularly (near the lesion), 64 UU (1 ml) are administered daily or every other day (10-20 injections in total).

    With traumatic lesions of the nerve plexus and peripheral nerves injected subcutaneously into the region of the affected nerve (64 UE in a procaine solution) every other day; on the course - 12-15 injections. The course of treatment, if necessary, is repeated.

    Using at ophthalmic practice the contents of the vial are dissolved in 20 ml of water for injection (0.1% solution). The drug is administered subconjunctival - 0.3 ml, parabulbar - 0.5 ml, and also by electrophoresis.

    Patients with pulmonary tuberculosis with a productive nature of inflammation prescribe in complex therapy to increase the concentration antibacterial medicinal products means in the lesions in the form of injections and / or inhalations. Inhalations are carried out daily 1 time per day. For one inhalation, the contents of the vial (64 UE) are dissolved in 5 ml of 0.9% sodium chloride solution. The course of treatment consists of 20-25 inhalations. If necessary, repeat courses at intervals of 1.5-2 months.

    Outer, in the form of bandages, impregnated with the solution of the preparation. To prepare the solution, every 64 UE is dissolved in 10 ml of sterile 0.9% sodium chloride solution or boiled water at room temperature temperature. This solution is moistened with a sterile dressing, folded in 4-5 layers, applied to the affected area, covered with wax paper and fixed with a soft bandage. The bandage is applied daily for 15-18 hours for 15-60 days. With long-term use every 2 weeks make a break for 3-4 days.

    When applied by electrophoresis 1 vial of the preparation (64 UE) is dissolved in 60 ml of distilled water, 2-3 drops of 0.1% hydrochloric acid are added and injected from the anode onto the affected area for 20-30 minutes. The course of treatment - 15-20 sessions.Application dosage can be alternated with electrophoresis. The prepared solution should be used within 24 hours.

    Side effects:

    Allergic reactions; with prolonged use - local irritant effect.

    Overdose:

    Symptoms: chills, nausea, vomiting, dizziness, tachycardia, lowering of arterial pressure, local edema, urticaria, erythema.

    Treatment: the introduction of epinephrine, glucocorticosteroids, antihistamines.

    Interaction:

    Improves the absorption of drugs administered subcutaneously or intramuscularly, enhances the effect of local anesthetics.

    Special instructions:

    The solution should not be administered via a catheter into which it was previously administered solutions containing cations.

    Solutions for injection are prepared on 0.9% solution of sodium chloride or 0.5% solution of procaine, for inhalations - 0.9% solution of sodium chloride, for electrophoresis - on distilled water.

    Before starting treatment, it is advisable to perform a test with intradermal administration of 20 μl of hyaluronidase.

    Do not enter into areas of infectious inflammation and tumors.

    In acute hemorrhages, hyaluronidase should not be used.

    Effect on the ability to drive transp. cf. and fur:

    The use of the drug does not affect the management of vehicles and the employment of other potentially hazardous activities that require an increased concentration of attention and speed of psychomotor reactions.

    Form release / dosage:

    Liofilizate for solution for injection and topical application, 64 UE.

    Packaging:

    According to 64 UE (conventional units) of the active substance in 5 ml glass vials, sealed with rubber medical closures, rolled aluminum caps or crimped caps combined of aluminum with a plastic cover.

    For 5 or 10 bottles together with a liner made of polyvinylchloride film and with instructions for medical use of the drug in a pack of cardboard.

    Storage conditions:

    In the dark place at a temperature of no higher than 15 ° C.

    Keep out of the reach of children.

    Shelf life:

    2 years.

    Do not use after the expiration date.

    Terms of leave from pharmacies:On prescription
    Registration number:P N000820 / 01
    Date of registration:29.05.2009 / 17.10.2017
    Expiration Date:Unlimited
    The owner of the registration certificate:SAMSON-MED, LLC SAMSON-MED, LLC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp28.02.2018
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