Active substanceHyaluronidaseHyaluronidase
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  • Dosage form: & nbsplyophilizate for solution for injection and topical application
    Description:

    Lyophilized powder or porous mass, compacted into a white or white tablet with a yellowish, pinkish or brownish tinge.

    Pharmacotherapeutic group:Enzyme agent
    ATX: & nbsp

    V.03.A.X   Other medications

    Pharmacodynamics:

    Enzyme preparation isolated from testes of cattle.

    Cleaves the major component of the connective tissue interstitial substance - hyaluronic acid (mucopolysaccharide, which consists of acetylglucosamine and glucuronic acid, a cementing substance of connective tissue), reduces its viscosity, increases vascular permeability and the fabric, facilitates the movement of fluids in the interstices spaces; reduces puffiness of the tissue, softens and flattens scars, increases the amount of movement in the joints, reduces contractures and prevents their formation. Hyaluronidase causes the decomposition of hyaluronic acid to glucosamine and glucuronic acid and thereby reduces its viscosity.

    Duration of action for intradermal administration is up to 48 h.

    Indications:

    Burn, traumatic, postoperative scars; long-term non-healing ulcers (including radiation ulcers); Dupuytren's contracture; stiffness of the joints, joint contractures (after inflammation, trauma), osteoarthritis, ankylosing spondylitis, severe lumbar disc disease; chronic tenosynovitis, scleroderma (skin manifestations), soft tissue hematoma of surface localization; preparation for skin and plastic surgery for scarring.

    Tuberculosis of the lungs (complicated by nonspecific lesions of the bronchi), inflammatory processes in the upper respiratory tract and bronchial tubes with obstruction phenomena.

    Traumatic lesions of nerve plexuses and peripheral nerves (plexitis, neuritis).

    Hyphema, hemophthalmus, retinopathy of various etiologies.

    Contraindications:

    Hypersensitivity, acute infectious and inflammatory diseases, recent hemorrhages.

    For inhalation, pulmonary tuberculosis with severe respiratory failure; pulmonary hemorrhage, hemoptysis; malignant neoplasms, fresh vitreous hemorrhage.

    Concomitant reception of estrogens.

    Carefully:Pregnancy, lactation.
    Dosing and Administration:

    With cicatricial lesions subcutaneously (under the scar tissue) or intramuscularly (near the lesion), 64 UU (1 ml) are administered daily or every other day (10-20 injections in total).

    With traumatic lesions of the nerve plexus and peripheral nerves injected subcutaneously into the region of the affected nerve (64 UE in a procaine solution) every other day; for a course of 12-15 injections. The course of treatment, if necessary, is repeated.

    Using in ophthalmic practice the drug is administered subconjunctivally - 0.3 ml, parabulbar - 0.5 ml, and also by electrophoresis.

    Patients with pulmonary tuberculosis with a productive nature of inflammation prescribe in complex therapy to increase the concentration of antibacterial drugs in the lesions in the form of injections and / or inhalations. Inhalations are performed daily 1 time, using 5 ml of solution (320 UE).The course of treatment consists of 20-25 inhalations. If necessary, repeat courses at intervals of 1.5-2 months.

    In the form of dressings, impregnated with the solution of the preparation. To prepare a solution every 64 UE is dissolved in 10 ml sterile 0.9% solution of sodium chloride or boiled water at room temperature. This solution is moistened with a sterile dressing, folded in 4-5 layers, applied to the affected area, covered with wax paper and fixed with a soft bandage. The dose depends on the area of ​​the lesion (32-64 UU / cm2), on average - 320 UE per bandage. The dressing is applied daily for 15-18 hours for 15-60 days. With long-term use every 2 weeks make a break for 3-4 days.

    When applied by electrophoresis 320 UE is dissolved in 64 ml of distilled water, 2-3 drops of 0.1%% solution of hydrochloric acid and injected from the anode onto the affected area within 20-30 minutes. The course of treatment - 15-20 sessions. Application dosage can be alternated with electrophoresis. The prepared solution should be used within 24 hours.

    Side effects:

    Allergic reactions; with prolonged use - local irritant effect.

    Overdose:

    Symptoms: chills, nausea, vomiting, dizziness, tachycardia, lowering of arterial pressure, local edema, urticaria, erythema.

    Treatment: the introduction of epinephrine, glucocorticosteroids; antihistamines.

    Interaction:

    Improves the absorption of drugs administered subcutaneously or intramuscularly, enhances the effect of local anesthetics.

    Special instructions:

    The solution should not be administered through a catheter into which solutions containing cations were previously administered.

    Solutions for injection are prepared on a 0.9% solution of sodium chloride or 0.5% solution of procaine, for inhalations - by 0.9% solution of sodium chloride, for electrophoresis - on distilled water.

    Before starting treatment, it is advisable to perform a test with intradermal administration of 20 μl of hyaluronidase.

    Do not enter into areas of infectious inflammation and tumors.

    In acute hemorrhages, hyaluronidase is not used.
    Form release / dosage:Liofilizate for solution for injection and topical application, 64 UE.
    Packaging:

    In ampoules or bottles of 64 UE.

    For 5 or 10 ampoules or vials in a pack or box of cardboard with instructions for use, a knife or a scarifier ampoule if necessary.

    For 5 or 10 ampoules in a contour cell package. For 1 or 2 contour packs in a pack of cardboard with instructions for use, a knife or scarifier ampoule if necessary.

    For hospitals: 5, 10, 12, 20 contour-cell packings in a cardboard box together with instructions for use and a knife or scarifier ampoule if necessary.

    In the form of a kit: an ampoule or vial with a drug and an ampoule with a solution of novocaine for injection of 5 mg / ml of 5 ml or a solution of sodium chloride for injection of 0.9% to 2 ml is one set. For 5 sets with instructions for use with a knife or scarifier ampoule (if necessary) stacked in 10 local boxes or packs of cardboard.

    Storage conditions:

    In the dark place at a temperature of no higher than 15 ° C.

    Keep out of the reach of children.

    Shelf life:

    2 years.

    Do not use after the expiry date printed on the package.

    Terms of leave from pharmacies:On prescription
    Registration number:LSR-001050/08
    Date of registration:26.02.2008 / 27.05.2013
    Expiration Date:Unlimited
    The owner of the registration certificate:MICROGEN FGUP Scientific and Production Association MICROGEN FGUP Scientific and Production Association Russia
    Manufacturer: & nbsp
    Representation: & nbspMICROGEN FGUP Scientific and Production Association MICROGEN FGUP Scientific and Production Association Russia
    Information update date: & nbsp28.02.2018
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