Dextran 40 (Dextran 40)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceDextranDextran
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    • Dosage form: & nbspsolution for infusions
    Composition:

    Dextran [co-sol. Mass 35000-45000] 100 g.

    Excipients: sodium chloride 9 grams, water for injection up to 1 liter.

    Description:Transparent, colorless or slightly yellowish liquid.
    Pharmacotherapeutic group:Plasmasuberant
    ATX: & nbsp

    B.05.A.A   Blood plasma preparations and plasma-substituting drugs

    Pharmacodynamics:

    Reduces and prevents the aggregation of blood elements, facilitates the movement of fluid from the tissues into the bloodstream. Increases the suspension properties of blood, reduces its viscosity, helps restore blood flow in small capillaries, has a detoxification effect.

    Pharmacokinetics:

    It is excreted by the kidneys (24 hours to 70%).

    Indications:

    Preventive maintenance and treatment of traumatic, operational and burn shock; violations of arterial and venous circulation, treatment and prevention of thrombosis and thrombophlebitis, endarteritis; for addition to a perfusion fluid in cardiac operations performed using an artificial circulation device; to improve local circulation in vascular and plastic surgery; for detoxification with burns, peritonitis, pancreatitis.

    Diseases of the retina and optic nerve, inflammatory processes of the cornea and the choroid of the eye.

    Contraindications:

    Hypersensitivity, thrombocytopenia, kidney disease with anuria and other conditions in which it is undesirable to administer large amounts of fluid; deficiency of fructose-1,6-diphosphatase, pulmonary edema, hyperkalemia.

    Pregnancy and lactation:

    The use of the drug during pregnancy is possible only if the intended benefit to the mother exceeds the potential risk to the fetus.

    It should refrain from breastfeeding during the period of use of the drug because of the lack of relevant clinical data.

    Dosing and Administration:

    Intravenously (struino and drip).

    The dose is set individually and depends on the clinical situation and the patient's condition. Because of the possibility of developing anaphylactic reactions, the drug is injected slowly for the first 10-20 minutes.

    To prevent and treat violations of capillary blood flow associated with traumatic, surgical and burn shock, 400-1000 ml per day (for 30-60 minutes) are used.

    In surgical interventions on the heart and vessels, 10 ml / kg is administered before the operation, 400-500 ml during the operation and 10 ml / kg per injection for 5-6 days after the operation.

    For detoxification, 5-10 ml / kg is administered within 60-90 minutes.

    Children the total dose should not exceed 15 ml / kg / day. In cardiovascular operations, children under the age of 2-3 years are administered 10 ml / kg once a day (for 60 min), up to 8 years - 7-10 ml / kg (1-2 times per day), up to 13 years - 5-7 ml / kg (1-2 times a day), over 14 years - a dose for adults.

    Side effects:

    Allergic reactions (skin hyperemia, skin rash), nausea, fever, anaphylactic shock.

    Interaction:

    Together with the preparation, it is advisable to administer crystalloid solutions in such quantity to compensate and maintain the liquid and electrolyte balance.

    When used simultaneously with anticoagulants, their dose should be reduced.

    Special instructions:

    Dextrans are able to envelop the surface of erythrocytes, preventing the determination of blood group, therefore it is necessary to use washed red blood cells.

    Effect on the ability to drive transp. cf. and fur:

    Not found.

    Form release / dosage:

    Solution for infusions, 10%.

    Packaging:

    200 ml or 400 ml in glass bottles for blood, transfusion and infusion preparations.

    1 bottle with instructions for use in a pack of cardboard.

    For 20, 24 or 28 bottles with a capacity of 250 ml or 15 bottles with a capacity of 450 ml with an equal number of instructions for use in a cardboard box with partitions (for hospitals).

    Storage conditions:

    Store at a temperature not exceeding 25 ° C.

    Keep out of the reach of children.

    Note. Freezing the drug, provided that the bottle is not leaking, and also the non-wetting of the inner surface of its wall are not grounds for refusing to use it.

    Shelf life:

    2 years.

    Do not use after the expiration date indicated on the label.

    Terms of leave from pharmacies:On prescription
    Registration number:LS-001873
    Date of registration:25.01.2012 / 02.09.2014
    Expiration Date:Unlimited
    The owner of the registration certificate:Kursk Biofactory - BIOK, FKPKursk Biofactory - BIOK, FKP Russia
    Manufacturer: & nbsp
    Information update date: & nbsp22.03.2017
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