Reopoliglukin (Rheopolyglukin)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceDextranDextran
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    • Dosage form: & nbspsolution for infusions
    Composition:10% colloidal solution of dextran with a molecular weight of 30,000 to 40,000 with the addition of an isotonic sodium chloride solution.
    Description:

    Transparent, colorless or slightly yellow liquid.

    Pharmacotherapeutic group:plasma-substituting agent
    ATX: & nbsp

    B.05.A.A   Blood plasma preparations and plasma-substituting drugs

    Pharmacodynamics:

    Reopoliglyukin is a preparation of low molecular weight dextran. It reduces the aggregation of blood elements, facilitates the movement of fluid from tissues into the bloodstream. In this regard, the drug increases the suspension properties of blood, reduces its viscosity, helps restore blood flow in small capillaries,has a detoxification effect, prevents and reduces the aggregation of blood cells.

    Dextran is excreted from the body through the kidneys (on the first day up to 70%).

    Indications:

    Reopoliglyukin is used for violations of capillary blood flow, for the prevention and treatment of traumatic, surgical and burn shock; violations of arterial and venous circulation, for the treatment and prevention of thrombosis and thrombophlebitis, endarteritis; at operations on heart spent with use of the device of an artificial circulation (for addition to a perfusion liquid); in vascular and plastic surgery to improve local circulation; for detoxification with burns, peritonitis, pancreatitis, etc.

    Reopoliglyukin is prescribed for diseases of the retina and optic nerve, inflammatory processes of the cornea and the vascular membrane.

    Contraindications:

    The drug is contraindicated in thrombocytopenia, kidney disease (with anuria), heart failure and in cases where large quantities of liquid should not be administered.

    Allergy to dextran in the anamnesis.

    Dosing and Administration:

    Reopoliglyukin is administered only intravenously!

    The dose is set individually and depends on the clinical situation and the patient's condition.

    In order to prevent and treat violations of capillary blood flow associated with traumatic, operating and burn shock, use intravenously drip 400-1000 ml per day (for 30-60 minutes).

    In surgical interventions on the heart and vessels intravenously drip 10 ml / kg before the operation, during the operation 400-500 ml and for 5-6 days after the operation, 10 ml / kg per injection.

    Children the total dose should not exceed 15 ml / kg of body weight / day.

    In cardiovascular operations children under the age of 2-3 years are administered 10 ml / kg once a day (for 60 minutes), up to 8 years - 7-10 ml / kg (1-2 times per day), up to 13 years - 5 -7 ml / kg (1-2 times a day), over 14 years - a dose for adults. For detoxification, 5-10 ml / kg is administered within 60-90 minutes.

    In ophthalmic practice Reopoliglyukin is used by electrophoresis. The procedure is carried out once a day. Apply 10 ml (from the positive and negative pole, the current density to 1.5 mA / cm2).

    Side effects:Allergic reactions: redness of the skin, rashes on the skin, nausea, fever, anaphylactic shock.
    Interaction:

    It is necessary to check the compatibility of dextran with drugs that are planned for introduction into the infusion solution.

    Form release / dosage:Solution for infusions, 10%.
    Packaging:

    In glass bottles of 100, 200 and 400 ml.

    Storage conditions:

    Store in a dry place at a temperature of 10 ° C to 25 ° C.

    Freezing is permissible during transportation of the preparation.

    With a drop in temperature during the transport of the drug, white films, which are dextran particles, may appear. In this case, it is necessary to dissolve the film by heating the bottle with the preparation in a boiling water bath for 1 hour with periodic shaking or autoclaving at 120 ° C for 20 minutes, cool the preparation to body temperature and use it for the intended purpose.

    Shelf life:

    4 years.

    The drug should be used before the date indicated on the package.

    Terms of leave from pharmacies:On prescription
    Registration number:P N001783 / 01
    Date of registration:15.08.2008 / 14.08.2015
    The owner of the registration certificate:Promomed Rus, Open CompanyPromomed Rus, Open Company Russia
    Manufacturer: & nbsp
    Information update date: & nbsp10.01.2016
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