Hemostabil - instructions for use, dose, side effects, contraindications

Hemostabil - a complex drug, which is a hypertonic solution. Under the action of the hypertonic component (high concentration of sodium chloride, osmolarity of 2567 mOsm) water, mainly from the interstitial space, quickly moves to the vascular bed, increasing the volume of intravascular fluid.The action of hypertonic saline is short-lived due to the elimination of sodium and chlorine ions from the vessels. Dextran 40 for 3-4 hours retains fluid in the bloodstream, maintains the volume of circulating blood, thus providing hemodynamic action. The maximum effect on the volume of circulating blood is the total effect of the hypertonic solution and dextran 40. The drug has a volemic effect within 150-200% of the introduced volume, which persists for 30-60 minutes. Infusion with 250 ml of Hemostable gives an increase in the intravascular volume of the liquid to 1000 ml for 5 minutes.

Pharmacokinetics:

The combination of sodium chloride and dextran 40 does not change the pharmacokinetic properties of each component. The content of sodium in the blood plasma after the administration of Hemostable increases to 9-12 mmol / l, returning to normal values in less than 4 hours. The half-life of "Dextran 40" is 3-4 hours, it is excreted by the kidneys with urine unchanged.

Indications:

It is intended for initial replacement of circulating blood volume deficiency for the prevention and treatment of hypovolemia and shock with hypotension in acute blood loss, trauma, wounds, surgical interventions, burns, and infectious diseases.

Contraindications:

Known hypersensitivity / allergy to the drug or its constituents; late pregnancy and lactation; severe cardiopulmonary insufficiency; renal dysfunction, hyperhydration.

Childhood.

Carefully:With caution appoint the drug for severe violations of blood coagulation (other than life-threatening conditions), dehydration.

Since Hemostabil for a short time significantly increases the volume of intravascular fluid, attention should be paid to patients with heart failure.

In patients with diabetes mellitus with severe hyperglycemia and hyperosmolarity, Hemostabil should be used with caution.

Dosing and Administration:

Hemostabil is prescribed in the form of intravenous infusions in peripheral or central veins. Introduction is carried out once, struino in a dose of 250 ml, for 2-4 minutes. 250 ml of the drug Hemostabil is the optimal dose.

Increasing the volume of circulating blood and stabilizing hemodynamics reduces the risk of developing irreversible pathological reactions of the organism in response to acute hypovolemia. After the transfusion of the drug, Hemostabil, the infusion therapy is continued using crystalloid and colloidal solutions, blood preparations in the required volumes.It is preferable to use isotonic solutions following the administration of Hemostable.

Side effects:Individuals may experience intolerance, and in exceptional cases, allergic reactions of various types, up to anaphylactic / anaphylactoid phenomena. In this case, the drug should be stopped immediately and the necessary emergency measures taken.

Overdose:

Symptoms of overdose are not established.

Interaction:

Interaction with other drugs and preparations was not revealed.

Special instructions:

In the process of treatment, it is necessary to control the ion composition of blood serum, the balance of fluid and the function of the kidneys.

When the drug is injected into the peripheral veins, a burning sensation and tenderness may appear in the limb along the vein in which the drug is infused.

Form release / dosage:Solution for infusion.

Packaging:

For 100, 250, 500 ml in polymeric containers for single-use infusion solutions.

Each container is packaged in a secondary bag with instructions for use.

Storage conditions:

In a dry place, at a temperature of 10 to 30 ° C.Freezing during transportation is allowed.

Keep out of the reach of children.

Shelf life:

2 years.

Do not use after the date shown on the package.

Terms of leave from pharmacies:On prescription

Registration number:LS-000634

Date of registration:06.05.2010 / 18.05.2012

Expiration Date:Unlimited

The owner of the registration certificate:Hematology Research Center, FGBU of the Ministry of Health of the Russian FederationHematology Research Center, FGBU of the Ministry of Health of the Russian Federation Russia

Manufacturer: & nbsp

FIRM MEDPOLIMER, JSC Russia

Information update date: & nbsp21.03.2017

Illustrated instructions

Instructions

Hemostabil (Hemostabil)