Dolospa tabs (Dolospa tabs)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceDicycloverine + ParacetamolDicycloverine + Paracetamol
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  • Dolospa tabs
    pills inwards 
    Outline Pharma Pvt. Ltd.     India
  • Trigan-D
    pills inwards 
    Cadil Pharmaceuticals Co., Ltd.     India
    • Dosage form: & nbspPills.
    Composition:
    Active substances:
    paracetamol - 500 mg, dicycloridine hydrochloride - 20.0 mg;
    Excipients:
    corn starch, gelatin, calcium
    hydrophosphate, talc, magnesium stearate.

    Description:Flat, round tablets from white to white with a creamy shade of color with bevelled edges, with a risk on one side.
    Pharmacotherapeutic group:Analgesic combined (analgesic non-narcotic remedy + antispasmodic)
    ATX: & nbsp

    N.02.B.E.51   Paracetamol in combination with other drugs, excluding psycholeptics

    Pharmacodynamics:
    Combined drug, the effect of which is determined by the properties of the constituent drugs.
    Paracetamol is a non-narcotic analgesic, blocks cyclooxygenase (COX) 1 and 2 mainly in the central nervous system (CNS), affecting pain centers and thermoregulation. In inflamed tissues, cellular peroxidases neutralize the effect of paracetamol on COX, which explains the almost complete absence of anti-inflammatory effect.The absence of a blocking effect on the synthesis of prostaglandin in peripheral tissues determines the absence of a negative effect on water-salt metabolism (sodium and water retention) and gastrointestinal mucosa (GI tract).
    Dicycloverin is a tertiary amine that has a relatively weak indiscriminate m-cholinoblocking and direct myotropic antispasmodic effect on the smooth muscles of the internal organs. In therapeutic doses, it causes relaxation of smooth muscles, which is not accompanied by side effects typical of atropine.

    Indications:Dolospa Tabs is used for diseases accompanied by a spasm of smooth muscles of the internal organs: intestinal colic, renal colic, biliary colic, algodismenorea, irritable bowel syndrome, spastic constipation, pilorospasm.
    Contraindications:
    Hypersensitivity to paracetamol or dicycovinone, as well as to the auxiliary substances that make up the drug.
    Severe renal and / or hepatic insufficiency, congenital deficiency of glucose-6-phosphate dehydrogenase, oppression of bone marrow hematopoiesis; childhood.

    Carefully:Hepatic and / or renal failure of mild to moderate severity, angle-closure glaucoma, urinary retention (including against the background of prostatic hyperplasia), congenital hyperbilirubinemia (Gilbert syndrome, Dubin-Johnson syndrome and Rotor), elderly age.
    Pregnancy and lactation:The use of the drug during pregnancy and lactation is contraindicated.
    Dosing and Administration:Inside, 1 tablet 2-3 times a day. The maximum single dose for adults - 2 tablets, daily - 4 tablets. Duration of reception - no more than 5 days. Increase the dose or duration of use only after consultation with your doctor.
    Side effects:
    Allergic reactions (skin rash, itching, hives, angioedema), nausea, pain in the epigastric region; anemia, thrombocytopenia, agranulocytosis, dryness of the oral mucosa, dizziness, accommodation paresis, mydriasis, blurred vision, vomiting, decreased potency, urinary retention, drowsiness.
    With prolonged use in large doses - hepatotoxic effect, hemolytic anemia, aplastic anemia, methemoglobinemia, pancytopenia; nephrotoxicity (glucosuria, interstitial nephritis, papillary necrosis).
    Overdose:
    Overdose symptoms mainly due to paracetamol: during the first 24 hours after administration - paleness of the skin, nausea, vomiting, anorexia, abdominal pain; disturbance of glucose metabolism, metabolic acidosis. Symptoms of liver dysfunction may appear 12-48 hours after an overdose. In severe overdose - liver failure with progressive encephalopathy, coma, death; acute renal failure with tubular necrosis (including in the absence of severe liver damage); arrhythmia, pancreatitis.
    Hepatotoxic effect in adults is manifested when taking 10 g or more. Symptoms, caused by dicycloridine: tachycardia, tachypnea,
    hyperthermia, CNS excitation.
    Treatment: with a recent overdose (at the prehospital stage) - gastric lavage, Activated carbon; inpatient - introduction donators SH-groups and precursors of glutathione synthesis - methionine for 8-9 hours after the overdose of paracetamol and acetylcysteine ​​-. for 8 hours The need for additional therapeutic activities (further administration of methionine, acetylcysteine ​​intravenous administration) is determined depending on the the concentration of paracetamol in the blood, as well as the time elapsed after its administration.Conduct also symptomatic treatment.
    Interaction:
    Paracetamol
    Reduces the effectiveness of uricosuric medicines (LS).
    The concomitant use of paracetamol in high doses increases the effect of anticoagulant drugs (a decrease in the synthesis of procoagulant factors in the liver).
    Inductors of microsomal oxidation in the liver (phenytoin, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants), ethanol and hepatotoxic drugs increase the production of hydroxylated active metabolites, which allows the development of severe intoxication even with a slight overdose.
    Long-term use of barbiturates reduces the effectiveness of paracetamol. Ethanol promotes the development of acute pancreatitis against the background of the use of paracetamol.
    Inhibitors of microsomal oxidation (incl. cimetidine) reduce the risk of hepatotoxic effects. Prolonged simultaneous reception. paracetamol and non-steroidal anti-inflammatory drugs increases the risk of developing "analgesic" nephropathy and renal papillary necrosis, the onset of the terminal stage of renal failure.Simultaneous long-term use of paracetamol in high doses and salicylates increases the risk of developing kidney or bladder cancer. Diflunisal increases the plasma concentration of paracetamol by 50%, which increases the risk of hepatotoxicity.
    Myelotoxic drugs increase the manifestation of hematotoxicity of the drug. Dicycoxyverine
    The effect is enhanced amantadine, antipsychotic and antiarrhythmic drugs of class I, benzodiazepines, monoamine oxidase inhibitors, narcotic analgesics, nitrates and nitrites, adrenostimulators, tricyclic antidepressants, m-cholinoblockers, glucocorticosteroids. Reducing the peristalsis of the gastrointestinal tract, increases the absorption of digoxin, increasing its concentration in the blood.


    Special instructions:
    With prolonged use during treatment, monitoring of the peripheral blood picture and the functional state of the liver is necessary.
    Paracetamol distorts the results of laboratory studies in the quantitative determination of glucose and uric acid in plasma.
    To avoid toxic damage to the liver, paracetamol-containing preparations should not be combined with the intake of alcoholic beverages.

    Effect on the ability to drive transp. cf. and fur:During the treatment period it is necessary to refrain from potentially dangerous activities requiring increased attention, because dicycloridine can lead to drowsiness and indistinctness of visual perception.
    Form release / dosage:

    Pills.

    Packaging: For 10 tablets in a foil blister of aluminum and PVC. For 2 or 10 blisters with instructions for use in a cardboard box.
    Storage conditions:In a dry, protected from light place at a temperature of no higher than 25 ° C.
    Keep out of the reach of children.
    Shelf life:
    4 years.
    Do not use the drug after the expiration date.

    Terms of leave from pharmacies:Without recipe
    Registration number:П N011506 / 01
    Date of registration:18.08.2010
    The owner of the registration certificate:Outline Pharma Pvt. Ltd.Outline Pharma Pvt. Ltd. India
    Manufacturer: & nbsp
    Representation: & nbspNPK Katren AONPK Katren AORussia
    Information update date: & nbsp07.01.2016
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