Trigan-D (Trigan-D)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceDicycloverine + ParacetamolDicycloverine + Paracetamol
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  • Dolospa tabs
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    Outline Pharma Pvt. Ltd.     India
  • Trigan-D
    pills inwards 
    Cadil Pharmaceuticals Co., Ltd.     India
    • Dosage form: & nbspPills.
    Composition:
    Each tablet contains:
    Active substances:
    paracetamol - 500 mg
    dicycloserin hydrochloride 20 mg
    Excipients: sodium starch glycolate, maize starch, microcrystalline cellulose, povidone, silicon dioxide colloid (aerosil), magnesium stearate.

    Description:White round, flat smooth tablets with bevelled edges and risk on one side.
    Pharmacotherapeutic group:Analgesic agent (analgesic non-narcotic remedy + antispasmodic).
    ATX: & nbsp

    N.02.B.E.51   Paracetamol in combination with other drugs, excluding psycholeptics

    Pharmacodynamics:
    Included in the preparation paracetamol has analgesic, antipyretic and insignificant anti-inflammatory effect. The mechanism of action is associated with moderate inhibition of cyclooxygenase-1 and, to a lesser extent, cyclooxygenase-2 in peripheral tissues and the central nervous system, which results in inhibition of the biosynthesis of prostaglandins - modulators of pain sensitivity, thermoregulation and inflammation.
    The second component, dicycloridine hydrochloride, is a tertiary amine that has a relatively weak indiscriminate m-cholinoblock and direct myotropic antispasmodic effect on the smooth muscles of the internal organs. In therapeutic doses, it causes effective relaxation of smooth muscles, which is not accompanied by side effects characteristic of atropine.
    Combined action of the two components of Trigan-D provides relaxation of spasmodic smooth muscles of internal organs and easing of pain.
    Pharmacokinetics:The drug is well absorbed in the gastrointestinal tract. The maximum concentration in the blood plasma is reached after 60-90 min. The volume of distribution is 3.65 l / kg. Paracetamol metabolized in the liver with the formation of several metabolites, one of which - N-acetyl-benzoquinonimine - under certain conditions (drug overdose, glutathione deficiency in the liver) can have damaging effects on the liver and kidneys. About 80% of the drug is excreted in the urine and in small amounts - with feces.
    Indications:
    Spasm of smooth muscles of internal organs - intestinal, hepatic and renal colic, algodismenorea;
    Headache, dental, migraine pain, neuralgia, myalgia;
    Infectious-inflammatory diseases accompanied by fever.

    Contraindications:
    Hypersensitivity to paracetamol and dicyclovirin, obstructive diseases of the intestine, biliary and urinary tract, peptic ulcer and duodenal ulcer (exacerbation phase), reflux esophagitis, hypovolemic shock, myasthenia gravis.
    Children's age (up to 15 years).


    Carefully:With caution should be used in patients with severe impaired liver or kidney function, in the genetic absence of glucose-6-phosphate dehydrogenase, blood disease, glaucoma, benign hyperbilirubinemia (including Gilbert's syndrome), viral hepatitis, alcoholic liver damage, alcoholism, in old age .
    Pregnancy and lactation:Use during pregnancy and lactation is contraindicated.
    Dosing and Administration:
    It is administered to adults and children over 15 years of age for 1 tablet 2-3 times a day. The maximum single dose for adults is 2 tablets, daily - 4 tablets. Duration of admission without consulting a doctor - no more than 5 days with an appointment as an anesthetic and 3 days - as an antipyretic.
    When the drug is used for a long time, it is necessary to monitor the pattern of peripheral blood and the functional state of the liver.
    Do not exceed the daily dose; Its increase or longer treatment is possible only under the supervision of a physician, since An overdose of the drug may cause hepatic insufficiency.

    Side effects:
    From the gastrointestinal tract: dry mouth, loss of taste, loss of appetite, epigastric pain, constipation, increased activity of "liver" enzymes, usually without the development of jaundice, hepatonecrosis (dose-dependent effect).
    Allergic reactions: skin rash, itching, urticaria, angioedema,
    multiforme exudative erythema (including Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome).
    From the side of the central nervous system (usually develops when taking high doses): drowsiness, dizziness, psychomotor agitation and impaired orientation.
    From the endocrine system: hypoglycemia, up to hypoglycemic
    coma.
    From the hematopoiesis: anemia, methemoglobinemia (cyanosis, dyspnea, heart pain), hemolytic anemia (especially for patients with deficiency of gluco-6-phosphate dehydrogenase).
    From the genitourinary system: pyuria, urinary retention, interstitial nephritis, papillary necrosis.
    On the part of the organs of vision: mydriasis, blurred vision, paralysis of accommodation, increased intraocular pressure.
    - decreased potency.
    Overdose:
    Symptoms: tachycardia, tachypnea, fever, agitation, convulsions,
    epigastric pain, decreased appetite, anemia, thrombocytopenia, hemolytic anemia, aplastic anemia, methemoglobinemia, pancytopenia, nephrotoxicity (papillary necrosis), hepatonecrosis.
    Treatment: stop taking the drug, do gastric lavage, prescribe adsorbents, introduce agents that increase the formation of glutathione (acetylcysteine intravenously) and enhancing conjugation reactions (methionine inside).
    Interaction:
    The action of dicycloverin enhances amantadine, antiarrhythmic drugs of the 1st class, antipsychotics, benzodiazepines, MAO inhibitors, narcotic analgesics, nitrates and nitrites, sympathomimetic drugs, tricyclic antidepressants.
    Dicycloverin increases the concentration of digoxin in the blood (due to a slowdown in gastric emptying).
    Stimulants of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites, which makes it possible to develop severe intoxications with small overdoses of paracetamol. Adrenostimulators, as well as other drugs with anticholinergic action, increase the risk of side effects. Inhibitors of microsomal oxidation (cimetidine) reduce the risk of hepatotoxic effects.
    Reduces the effectiveness of uricosuric drugs.
    Paracetamol improves the effectiveness of indirect anticoagulants.

    Special instructions:
    With caution and under the supervision of a doctor, the drug should be administered to patients with impaired liver or kidney function, along with other anti-inflammatory and analgesic agents, as well as with anticoagulants and drugs that affect the central nervous system. When taking metoclopramide, domperidone, or colestyramine, it is also necessary to consult a doctor.
    Paracetamol distorts the results of laboratory studies in quantifying the uric acid and glucose levels in the plasma.
    To avoid toxic damage to the liver paracetamol should not be combined with the reception of alcoholic beverages, but also to people prone to chronic alcohol consumption. The risk of liver damage increases in patients with alcoholic hepatosis.
    During long-term treatment, monitoring of the peripheral blood pattern and the functional state of the liver is necessary.
    Effect on the ability to drive transp. cf. and fur:When using the drug should refrain from potentially dangerous activities that require increased concentration and speed of psychomotor reactions (vehicle management, etc.).
    Form release / dosage:Pills
    Packaging:
    PVC / aluminum blister or aluminum strip, each containing 10 tablets. 1, 2 blisters or 10 strips together with instructions for use packed in a pack of cardboard.
    Storage conditions:List B.
    In a dry place protected from light and inaccessible to children at a temperature not exceeding 25 ° C.
    Shelf life:3 years.
    Do not use after the time specified on the package.
    Terms of leave from pharmacies:Without recipe
    Registration number:P N 015469/01
    Date of registration:25.05.2009
    The owner of the registration certificate:Cadil Pharmaceuticals Co., Ltd.Cadil Pharmaceuticals Co., Ltd. India
    Manufacturer: & nbsp
    Representation: & nbspCADILA PHARMACEUTICALS LTD. CADILA PHARMACEUTICALS LTD. India
    Information update date: & nbsp06.01.2016
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