Included in the formulation
АТХ:L.03.A.X Other immunostimulants
Pharmacodynamics:Pharmacological action - immunostimulating. Echinacea purpurea contains active substances that enhance the natural defenses of the body and act as stimulants of immunity.
Increases nonspecific resistance of the body. Stimulates the phagocytic activity of granulocytes, macrophages. It increases the body's resistance to infectious and colds, promotes the excretion of radionuclides, increases the functional activity of bone marrow and spleen cells, enhances antibody formation.
Thanks to inulin, levulose, betaine improves metabolic processes, especially in the liver and kidneys.
In addition, the antiviral effect of the herb of Echinacea purpurea has been established in relation to the pathogens of influenza and herpes.
Pharmacokinetics:Insufficiently investigated in humans.
Indications:Increase nonspecific factors of body protection in uncomplicated acute infectious diseases and with a predisposition to frequent catarrhal diseases; in order to stimulate immunity in patients with uncomplicated acute infectious diseases (as an auxiliary treatment); prevention of ARVI and influenza; as an auxiliary drug for prolonged antibiotic therapy of chronic infectious diseases.
X.J00-J06.J06.9 Acute upper respiratory tract infection, unspecified
X.J10-J18.J10 Influenza caused by an identified influenza virus
XXI.Z20-Z29.Z29.8 Other specified preventive measures
Contraindications:Tuberculosis, leukemia, autoimmune diseases (including collagenoses), common atherosclerosis, multiple sclerosis, AIDS, HIV infection, children under 4 years of age (for the dosage form - tablets),and up to 1 year (for the drug form - drops), increased sensitivity to Echinacea and other plants of the family Compositae.
Carefully:Patients with recurrent infectious diseases of the respiratory tract require regular medical supervision.
For forms containing in the composition of ethanol: diabetes mellitus, chronic liver disease, chronic alcoholism, bronchial asthma, children's age (up to 12 years). Pregnancy and lactation.
Pregnancy and lactation:Category of recommendations for FDA is not defined. Qualitative and well-controlled studies on humans and animals have not been conducted. Do not apply!
There is no information on the penetration into breast milk. Do not apply!
Dosing and Administration:Echinacea preparations are taken internally. The dose, frequency and duration of application are set individually, depending on the dosage form used.
Side effects:Possible: allergic reactions; when used in high doses - nausea, vomiting, stool disorders, insomnia, increased excitability of the nervous system.
Overdose:Symptoms: nausea, vomiting, diarrhea, insomnia, increased excitability of the nervous system.
Treatment: symptomatic.
Interaction:Cephalosporins containing a methylthiotetrazol group (cefamandol, cefaferazone) together with Echinacea containing ethanol, can cause tetur-like reactions (nausea, sweating, headaches, palpitations). Reactions may occur 3 days after the end of cefalosporin treatment.
Echinacea preparations together with immunosuppressants (azathioprine, basiliximab, ciclosporin, daclizumab, muro-mionab, mycophenolate, tacrolimus) weaken their immunosuppressive effect (do not apply before and after transplantation).
With the simultaneous use of Echinacea preparations with econazole (vaginal cream), the action of econazole decreases. Simultaneous use is not recommended.
Special instructions:Preference should be given to freshly prepared aqueous infusions from whole medicinal plant material.
During the period of application of Echinacea, no other immunostimulating drugs should be prescribed.
High doses affect the activity of sperm enzymes - reduce mobility by 24-48 hours.
Application can cause an increase in the biochemical parameters: ALT, AST, the number of lymphocytes, IgE levels in the serum,ESR and a decrease in serum ferritin.
It is necessary to avoid prolonged, more than 8 weeks of using the drug.
In the case of long-term storage of medicinal forms in the form of aqueous extracts, turbidity may develop, a precipitate consisting of active polysaccharides appears (shake several times before use). Turbidity and flocculent formations do not affect efficiency.