Epigen sex (Epigen intim)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceAmmonium glycyrrhizinateAmmonium glycyrrhizinate
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    • Dosage form: & nbspspray for local and external use
    Composition:Composition per 100 ml of the preparation:

    Active substance: Activated glycyrrhizic acid (equivalent to ammonium glycyrrhizinate) 0.1 g;

    excipients: malic acid 3.0 g; fumaric acid 2.0 g; ascorbic acid 0.3 g; folic acid 0.08 g; propylene glycol 50.0 g; Tween - 80 (polysorbate - 80) 0.9 g; water purified to 100 ml.

    Description:

    The solution is from light yellow to light brown, with a characteristic odor.

    Pharmacotherapeutic group:Antiviral immunostimulating drug
    ATX: & nbsp

    R.07.A.X   Other preparations for the treatment of respiratory diseases

    Pharmacodynamics:

    The active substance of the drug Epigen Intim is activated glycyrrhizic acid, obtained by extraction from plant raw materials (licorice root).

    Activated glycyrrhizic acid has a complex effect that includes immunostimulating, antiviral, anti-inflammatory, antipruritic and regenerative.

    Activated glycyrrhizic acid induces the production of intrinsic interferons. Immunostimulating effect is manifested by an increase in the number and activity of T-lymphocytes, a decrease in the concentration of immunoglobulin G and an increase in the concentration of immunoglobulin A and M.

    Activated glycyrrhizic acid has antiviral action on different types of DNA and RNA viruses in vitro and in vivo (Varicella Zoster; herpes simplex virus type 1 and 2; cytomegalovirus, various types of human papilloma virus, including oncogenic ones). Activated glycyrrhizic acid interrupts the replication of viruses in the early stages, causes the virion to leave the capsid, thereby preventing its entry into the cells. Activated glycyrrhizic acid inactivates said viruses in non-toxic for normally functioning cells concentrations. Mutant strains of viruses resistant to acyclovir and iodoridine are also highly sensitive to glycyrrhizic acid, as well as non-mutant strains. The anti-inflammatory activity of activated glycyrrhizic acid is combined with a stimulating effect on the humoral and cellular immunity factors.Activated glycyrrhizic acid significantly inhibits the release of kinins and the synthesis of prostaglandins by connective tissue cells in the inflammatory zone. Regenerating effect is due to improved skin and mucosal repair.
    Pharmacokinetics:

    With external and local application, activated glycyrrhizic acid is deposited in the lesions. Systemic absorption is slow. The drug is found in the blood in trace amounts.

    Indications:

    treatment of a viral infection caused by the human papillomavirus, including asymptomatic isolation of human papillomavirus of high oncogenic risk as part of combined and complex therapy;

    treatment of a viral infection caused by the herpes simplex virus type I and P types as part of complex therapy;

    treatment of viral infection caused by the virus Varicella Zoster (shingles) as part of complex therapy;

    treatment of viral infection caused by cytomegalovirus in the complex therapy;

    prevention of recurrence of viral infections caused by the herpes simplex virus I and II types, virus Varicella Zoster, human papillomavirus, cytomegalovirus.prevention and treatment of genital warts and cervical pathologies caused by human papillomavirus, cytomegalovirus.

    prevention and treatment of conditions, accompanied by a decrease in local

    immunity, including nonspecific vulvovaginitis, candidiasis

    vulvovaginitis and bacterial vaginosis, as part of complex therapy;

    with the phenomena of discomfort in the genital area, accompanied by itching,

    burning and dryness of mucous membranes, including after sexual intercourse;

    with the phenomena of discomfort in the genital area, accompanied by itching,

    burning and dryness of the mucous membranes in the failure of ovarian function.

    Contraindications:

    Hypersensitivity to the components of the drug.

    Pregnancy and lactation:

    The drug is approved for use throughout the period of pregnancy and lactation.

    Dosing and Administration:

    Outer, intravaginal and intraurethral.

    Before use, shake the can.

    When using the balloon, keep it in a vertical position.

    With external application, the drug is applied to the entire affected surface of the skin from a distance of 4-5 cm by 1 -2 valve strokes,which is the optimal therapeutic dose.

    For intravaginal application of the drug is attached a special nozzle with a nebulizer. Remove the valve from the spray bottle and attach the nozzle valve. Then attach the nozzle to the vagina and make an injection by 1-2 clicks of the nozzle, which is the optimal therapeutic dose.

    When used by men, in addition to external application, the drug is injected into the external opening of the urethra by 1-2 pressures of the valve of the atomizer.

    With type I herpesvirus infection, shingles the drug is recommended to be applied 6 times a day to the lesion center for 5 days. If the infectious process persists, the treatment period is prolonged until the symptoms disappear completely.

    With herpesviral infection type II (genital herpes), cytomegalovirus infection it is recommended to apply 5 times a day for 14 days externally and intravaginally, after relapsing relapse - externally and intravaginally 3 times a day for 10 days.

    FROM prevention of recurrence of genital herpes and cytomegalovirus infection the drug is recommended to be applied externally and intravaginally from the 18-20 day of the menstrual cycle until the end of menstruation 2 times a day in the morning and in the evening.

    With papillomavirus infection the drug is recommended for use:

    -to remove genital warts - 3 times a day during the entire period of etiotropic therapy.

    - against the background of destruction - 5 times a day for 10 days and more until complete healing, - to prevent immediate relapse 3 times a day for 1 month.

    To prevent the progression of papillomavirus infection it is recommended to apply before and after sexual intercourse, as well as in case of provoking factors (stress, overfatigue, respiratory viral infections, microflora disorders, antibiotics, cytotoxic agents) 3 times a day intravaginally and externally during the entire period of exposure to provoking factors.

    With bacterial vaginosis, nonspecific vulvovaginitis, and vulvovaginal candidiasis: the drug is recommended to be administered intravaginally 3-4 times a day for 7-10 days. If necessary, repeat treatment after 10 days. When there are provoking factors (respiratory viral infections, antibiotics,cytostatics) - 3 times a day intravaginally and externally during the entire period of exposure to provoking factors.

    In cases of discomfort in the genital area, accompanied by itching, burning and dryness of the mucous membranes: 2 once a day (morning and evening) for 2-3 weeks. To prevent conditions of discomfort, use regularly after intercourse.

    As a preventive antiviral agent, the drug is recommended to use before and after intercourse.

    Side effects:

    Individual intolerance of the drug components is possible.

    In rare cases, local allergic reactions are possible, including in the form of contact dermatitis.

    Interaction:

    There was no interaction with the main groups of drugs used for complex treatment for these diseases (antibiotics and antiseptics, anti-inflammatory and painkillers).

    Synergism was found with simultaneous use of activated glycyrrhizic acid and other antiviral drugs, in particular, derivatives of acyclovir, iodoridine, interferon and other immunomodulators.

    Special instructions:

    The nozzle is washed with boiled water and soap and stored in the attached polyethylene packaging.

    The design of the nozzle allows you to maintain the effect of uniform irrigation of the cervix and vaginal walls.

    For use in hospital settings, intravaginal irrigation with a drug in mirrors can be performed without a nozzle.

    For effective action, no preliminary washing of the application site is required.

    In case of signs of intolerance, stop using the drug.
    Form release / dosage:Spray for topical and topical application 0,1%.
    Packaging:For 15 ml and 60 ml in a plastic bottle with a nebulizer.
    The cylinder is packed in polyvinyl chloride film (control of the first opening). Each cylinder, together with a spray nozzle for intravaginal application and instructions for use, is packaged in a cardboard box.
    For 15 ml ("free sample") in a plastic bottle with a nebulizer. Each cylinder, together with a spray nozzle for intravaginal application and instructions for use, is packaged in a cardboard box.

    Storage conditions:

    At temperatures from 15 ° to 30 ° C, out of the reach of children.

    Shelf life:3 years. Do not use after expiry date.
    Terms of leave from pharmacies:Without recipe
    Registration number:П N011741 / 02
    Date of registration:22.07.2008
    The owner of the registration certificate:INVAR, LLC INVAR, LLC Russia
    Manufacturer: & nbsp
    Representation: & nbspINVAR LLC INVAR LLC Russia
    Information update date: & nbsp19.08.2014
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