Active substanceAmmonium glycyrrhizinateAmmonium glycyrrhizinate
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  • Dosage form: & nbspcream for local and external use
    Composition:

    in 100 g of the drug contains:

    Active substance:

    Glycyrrhizic acid activated by 0.10 g (equivalent to ammonium glycyrrhizinate)

    Excipients: Malic acid, fumaric acid, ascorbic acid, polavaks (macrogol 20 stearate + cetostearyl alcohol [Cetyl alcohol, 60% stearyl alcohol, 40%]) fenonip (methyl parahydroxybenzoate + ethyl parahydroxybenzoate + butyl parahydroxybenzoate + izobutilparagidroksibenzoat + propyl parahydroxybenzoate + phenoxyethanol), flavor (butyrate ( 2427) + allylcaproate (2032) + ethyl vanillin (2464) + ethylmaltol (692) + lemongrass oil + ethyl isovalerate (2463) + cis-3-hexanol (2563) + propylene glycol), butylhydroxytoluene, purified water.

    Description:Cream from white to dark yellow with a characteristic smell.
    Pharmacotherapeutic group:antiviral agent for topical use
    ATX: & nbsp

    R.07.A.X   Other preparations for the treatment of respiratory diseases

    Pharmacodynamics:

    Activated glycyrrhizic acid has antiviral, anti-inflammatory, regenerative, immunostimulating and antipruritic action.

    Effects on different types of DNA and RNA viruses in vitro and in vivo (Varicella zoster; Herpes simplex 1 and 2 type; different types of human papillomavirus, incl. oncogenic). Interrupts the replication of viruses in the early stages, causes the virion to emerge from the capsid, thereby preventing its penetration into the cells, which is associated with selective dose-dependent inhibition of phosphorylating kinase P.

    It interacts with the structures of the virus, changing the different phases of the viral cycle, which is accompanied by irreversible inactivation of virus particles that are in a free state outside the cells. It blocks the introduction of active viral particles into the cell, disrupting the ability of the virus to induce the synthesis of new viral particles. It induces the formation of interferon, which is one of the components of antiviral action.

    Inactivates these viruses in non-toxic concentrations for normally functioning cells.Mutant strains of viruses resistant to acyclovir and iodoridine are also highly sensitive to glycyrrhizic acid, as well as non-mutant strains. The anti-inflammatory activity of activated glycyrrhizic acid is combined with a stimulating effect on the humoral and cellular immunity factors. It significantly inhibits the release of kinins by cells of connective tissue in the area of ​​inflammation.

    The special composition of the cream determines its hydrating effect.
    Pharmacokinetics:

    With external and local application, activated glycyrrhizic acid accumulates in the lesions. Systemic absorption is extremely slow, therefore in biological fluids, activated glycyrrhizic acid is practically not detected.

    Indications:

    The drug is used to treat and prevent lesions of the lips, mucous membranes and skin in the mouth and nose with a virus Herpes simplex (including those accompanied by dryness, ulceration, cracks).

    Contraindications:Hypersensitivity to the components of the drug.
    Dosing and Administration:

    Locally, externally.

    Apply a thin layer of the cream without rubbing on the affected skin and mucous membrane 3-5 times a day for 3 days.If necessary, the course of treatment is continued until the symptoms of the disease completely disappear.
    Side effects:

    In rare cases, local allergic reactions are possible.

    Interaction:

    Synergism was found with simultaneous use of glycyrrhizic acid and other antiviral drugs, in particular, derivatives of acyclovir, iodoridine and interferon. During the course of treatment of a viral infection by the drug, the use of interferonogens is not recommended.

    Form release / dosage:

    Cream for local and external use 0,1%.

    Packaging:Cream for local and external use of 0.1% to 2.5 grams in the sachet "free sample." 5 grams per plastic tube. Each tube together with instructions for medical use is placed in a cardboard box.
    Storage conditions:At temperatures not higher than 30 ° C, out of reach of children.
    Shelf life:3 years. Do not use after expiry date.
    Terms of leave from pharmacies:Without recipe
    Registration number:П N011741 / 01
    Date of registration:29.12.2008
    The owner of the registration certificate:INVAR, LLC INVAR, LLC Russia
    Manufacturer: & nbsp
    Representation: & nbspINVAR LLC INVAR LLC Russia
    Information update date: & nbsp16.02.2010
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