From the hematopoiesis: leukopenia, neutropenia, rarely - thrombocytopenia, anemia. The most significant drop in the number of leukocytes is usually observed from 9 to 14 days (up to 25 days), platelets - from 7 to 17 days of treatment.
From the digestive system: loss of appetite, nausea, vomiting, inflammation and or ulceration of the mucous membranes of the gastrointestinal tract (including stomatitis), diarrhea, bleeding from the gastrointestinal tract, heartburn and taste change, impaired liver function.
From the side of cardio-vascular system: very rarely - pain in the heart, arrhythmias, ischemia, myocardial infarction, angina pectoris, heart failure.
From the nervous system: rarely - cerebellar ataxia, violation sensitivity, disorientation, confusion, euphoria, nystagmus, retrobulbar neuritis, headache.
From the sense organs: Irritation of the eye mucosa, excessive lachrymation due to duct stenosis (10% -25%), photophobia, cataract, cortical blindness (at high doses), visual impairment.
On the part of the reproductive system: reversible oppression of the sexual glands, leading to amenorrhea or azoospermia.
From the skin and skin appendages: alopecia (rarely), hyperpigmentation of the skin, dryness and skin cracks, telangiectasia, palmar-plantar erythrodysesthesia syndrome (tingling sensation in the hands and feet, followed by pain, hyperemia and swelling), nail plate changes and convergence (rarely), photosensitization.
Allergic reactions: skin rash, dermatitis, urticaria, flushing of the skin of the palms and soles, bronchospasm, anaphylaxis (rarely).
Other: fever (rare), thrombophlebitis at the injection site, epistaxis, cough, shortness of breath, hyperuricemia, weakness; development of secondary infections.