From the hematopoiesis: leukopenia, neutropenia, rarely - thrombocytopenia, anemia. The most significant drop in the number of leukocytes is usually observed from 9 to 14 days (up to 25 days), platelets - from 7 to 17 days of treatment. Very rarely, pancytopenia, agranulocytosis.
From the digestive system: anorexia, nausea, vomiting, inflammation and / or ulceration of the mucous membranes of the gastrointestinal tract (including stomatitis), diarrhea, bleeding from the gastrointestinal tract, heartburn and taste change, glossitis, pharyngitis, esophagitis, mucositis, impaired liver function, cholecystitis.
From the cardiovascular system: very rarely - pain in the heart, arrhythmias, myocardial ischemia, myocarditis, myocardial infarction, angina pectoris, heart failure, cardiomyopathy, cardiogenic shock, lowering blood pressure.
From the nervous system: rarely - cerebellar ataxia, impaired sensitivity, disorientation, confusion, euphoria, nystagmus, retrobulbar neuritis, asthenia, headache.
From the sense organs: conjunctivitis, irritation of the mucous membrane of the eyes, lacrimation due to stenosis of lacrimal ducts, photophobia, cataract, cortical blindness (at high doses), diplopia, visual impairment.
On the part of the reproductive system: reversible oppression of the sexual glands, leading to amenorrhea or azoospermia.
From the skin and skin appendages: alopecia, hyperpigmentation of the skin, dryness and skin cracks, telangiectasia, palmar-plantar erythrodysesthesia syndrome (tingling sensation in the hands and feet, followed by pain, hyperemia and swelling), change and convergence of nail plates (rarely), photosensitization.
Allergic reactions: skin rash, dermatitis, urticaria, bronchospasm, anaphylactic shock (rarely).
Other: "tide" of blood to the face, fever (rarely), thrombophlebitis at the injection site, epistaxis, cough, shortness of breath, hyperuricemia, weakness, development of secondary infections.