The incidence of side effects described below was determined according to the following gradation: very often (> 10%), often (> 1% and <10%), infrequently (> 0.1% and <1%), rarely (> 0.01% and <0.1%), very rarely (<0.01%).
Allergic reactions
infrequently - skin rash, dermatitis, urticaria, bronchospasm;
rarely anaphylactic shock
From the hematopoiesis:
very often - leukopenia, neutropenia, myelosuppression, mostly dose-limiting;
rarely - thrombocytopenia, anemia.
The most significant decrease in the number of leukocytes is usually observed from 9 to 14 days (up to 25 days), platelets from 7 to 17 days of treatment, very rarely - pancytopegy, agranulocytosis.
From the immune system:
very often - immunosuppression with an increase in the incidence of infectious diseases.
The frequency is unknown - an increase in the blood concentrations of total thyroxine (T4) and total triiodothyronine (T3).
From the digestive system:
very often - anorexia, decreased appetite, inflammation and / or ulceration of the mucous membranes of the gastrointestinal tract (including stomatitis, pharyngitis, esophagitis, proctitis);
often - diarrhea, nausea, vomiting, heartburn, taste change;
infrequently - dehydration, bleeding from the gastrointestinal tract, impaired liver function, cholecystitis, mucositis, glossitis;
Very rarely - damage to the liver cells, lethal necrosis of the liver.
From the cardiovascular system:
Very often - ischemic changes on the ECG, dilated cardiomyopathy;
rarely - pain in the heart, arrhythmia, lowering blood pressure, myocarditis;
very rarely - myocardial infarction, heart failure, angina, cardiomyalgia, cardiogenic shock, violation of peripheral cerebral circulation, Raynaud's syndrome, cardiac arrest, sudden death.
Co side of the nervous system:
often - transient reversible cerebral syndrome (ataxia, confusion, extrapyramidal motor and cortical disorders), drowsiness, impaired sensation, euphoria, nystagmus, retrobulbar neuritis, headache, disorientation, asthenia;
infrequently - vertigo;
very rarely - leukoencephalopathy, cerebral infarction (with combined therapy with mitomycin or cisplastin).
From the sense organs
rarely - conjunctivitis, excessive lacrimation due to stenosis of lacrimal ducts, photophobia, diplopia, cortical blindness (at high doses), visual impairment, mucous membrane damage, cataracts, optic neuritis, limitation of eye mobility, eyelid reversal.
On the part of the reproductive system:
infrequently - reversible oppression of the function of the sexual glands, leading to amenorrhea or azoospermia.
From the skin and skin appendages:
often - alopecia (reversible);
infrequent - hyperpigmentation of the skin, depigmentation in the form of bands near the veins, dry and cracked skin, erythema, pruritus of skin, telangiectasia, photosensitization;
rarely - changes in nails (onycholysis, pain and thickening of the nail bed, paronychia), convergence of nail plates, syndrome of palmar-plantar erythrodysesthesia (tingling in the hands and feet, followed by pain, hyperemia, swelling and flaking).
Other:
infrequently, weakness; "tides" of blood to the skin of the face, thrombophlebitis at the injection site, thromboembolism;
rarely - fever, epistaxis, cough, shortness of breath, hyperuricemia, development of secondary infections, sepsis.