Heparin (Heparin)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceHeparin sodium + Benzocaine + Benzyl nicotinateHeparin sodium + Benzocaine + Benzyl nicotinate
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  • Heparin
    ointment externally 
    BIOSINTEZ, PAO     Russia
  • Heparin ointment
    ointment externally 
    BELMEDPREPARATY, RUP     Republic of Belarus
  • Heparin ointment
    ointment externally 
    NIZHFARM, JSC     Russia
    • Dosage form: & nbspointment for external use
    Composition:

    Active substances:


    Heparin sodium (in terms of

    - 0.0833 g

    heparin)

    (10000 ME)

    Benzocaine (anesthesin)

    -4.0 g

    Benzyl nicotinate

    - 0.08 g

    Excipients:


    Glycerol (glycerin distilled grade PK-94)

    - 11.7 g

    Vaseline (petroleum jelly)

    -5.5 g

    cosmetic stearin

    -3.3 g

    corn oil

    - 5.5 g

    emulsifier # 1

    - 8.0 g

    mEthyl parahydroxybenzoate (nipagine)

    -0.15 g

    Propylparahydroxybenzoate (nipazole)

    - 0.05 g

    purified water

    - up to 100 g
    Description:Ointment is white with a yellowish tinge.
    Pharmacotherapeutic group:Anticoagulant direct for topical application
    ATX: & nbsp

    C.05.B.A   Heparin-containing preparations for topical application

    C.05.B.A.53   Heparin in combination with other drugs

    Pharmacodynamics:Combination drug for external use, the effect of which is due to the properties of its constituent components. Anticoagulant direct action. Gradually released from the ointment heparin sodium reduces the inflammatory process and has an antithrombotic effect. Promotes resorption of existing ones and prevents the formation of new blood clots.It blocks thrombin synthesis, reduces platelet aggregation. Oppresses the activity of hyaluronidase, activates fibrinolytic properties of blood. Benzyl ester of nicotinic acid expands the surface vessels, contributing to the absorption of heparin. Local anesthetic benzocaine reduces the severity of pain. When applied to the skin, it has a local analgesic effect.
    Indications:Thrombophlebitis of superficial veins (prevention and treatment), postinjection and postinfusion phlebitis, external hemorrhoids, inflammation of postpartum hemorrhoids, trophic ulcers of the lower leg, elephantiasis, superficial periphlebitis, lymphangitis, surface mastitis, localized infiltrates and edema, trauma and bruises (incl. muscle tissue, tendons, joints), subcutaneous hematoma.
    Contraindications:Known hypersensitivity to the components of the ointment, ulcerative necrotic skin changes at places of presumed ointment application, decreased blood clotting, thrombocytopenia, increased bleeding.
    Pregnancy and lactation:The use of the drug during pregnancy is possible only if the expected benefit for the mother exceeds the potential risk to the fetus.
    Dosing and Administration:

    Outwardly.Ointment is applied a thin layer on the affected area at the rate of 0.5 - 1.0 g of ointment on a skin area 3 - 5 cm in diameter and gently rub the ointment into the skin.

    In thrombosis of external hemorrhoids, rectal tampons are used, ointment is applied to a coarse or linen base, which is applied directly to the thrombosed nodes and fixed. For the same purpose, you can use a tampon soaked in heparin ointment, which is injected into the anus.

    Ointment is used 2-3 times a day daily until the disappearance of inflammatory phenomena, on average from 3 to 7 days. The possibility of a longer treatment is determined by the doctor.

    Side effects:Hyperemia of the skin, allergic reactions.
    Overdose:Overdose is unlikely because of the low absorption of ointment components.
    Interaction:Do not prescribe locally with NSAIDs, tetracyclines, antihistamine drugs. It is not recommended to mix with other products for external use.
    Special instructions:

    Heparin ointment is not recommended for bleeding, as well as for open wounds, mucous membranes and in the presence of local purulent processes.Use with extreme caution with increased vascular permeability.

    The use of ointment is not recommended for deep venous thrombosis.

    Effect on the ability to drive transp. cf. and fur:The drug does not adversely affect the ability to drive vehicles and control mechanisms.
    Form release / dosage:Ointment for external use.
    Packaging:

    25 g in an aluminum tube or in a polymer tube.

    Tubu together with instructions for use are placed in a pack of cardboard.

    Storage conditions:

    In dry, dark place at a temperature of no higher than 20 ° C.

    Keep out of the reach of children.

    Shelf life:

    3 years.

    Do not use after the expiration date.

    Terms of leave from pharmacies:Without recipe
    Registration number:P N001706 / 01
    Date of registration:01.11.2008 / 11.09.2012
    Expiration Date:Unlimited
    The owner of the registration certificate:BIOSINTEZ, PAO BIOSINTEZ, PAO Russia
    Manufacturer: & nbsp
    Information update date: & nbsp24.03.2017
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