Heparin ointment (Heparin ointment)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceHeparin sodium + Benzocaine + Benzyl nicotinateHeparin sodium + Benzocaine + Benzyl nicotinate
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  • Heparin
    ointment externally 
    BIOSINTEZ, PAO     Russia
  • Heparin ointment
    ointment externally 
    BELMEDPREPARATY, RUP     Republic of Belarus
  • Heparin ointment
    ointment externally 
    NIZHFARM, JSC     Russia
    • Dosage form: & nbspointment for external use
    Composition:

    for 1 g:

    active substances: heparin sodium (in terms of heparin) -100 IU, benzocaine (anesthesin) - 40.0 mg, benzyl nicotinate - 0.8 mg;

    Excipients: glycerol 150.0 mg, emulsifier # 1 -80.0 mg, petrolatum 60.0 mg, stearic acid -50.0 mg, sunflower oil 50.0 mg, methyl parahydroxybenzoate 1.5 mg, propyl parahydroxybenzoate 0, 5 mg, purified water - up to 1 g.

    Description:Ointment is white with a yellowish tinge.
    Pharmacotherapeutic group:Anticoagulant direct action for topical application + other drugs
    ATX: & nbsp

    C.05.B.A   Heparin-containing preparations for topical application

    C.05.B.A.53   Heparin in combination with other drugs

    Pharmacodynamics:

    Heparin - an anticoagulant of direct action, belongs to the group of medium-molecular heparins. With external application has a local anticoagulant, anti-exacerbation, moderate anti-inflammatory effect. It blocks the formation of thrombin.Heparin reduces the inflammatory process and has an anticoagulant effect, indirectly improves microcirculation, which contributes to the process of resorption of hematomas and blood clots and a reduction in swelling of the tissues.

    Benzocaine is a local anesthetic for surface anesthesia. Reducing the permeability of the cell membrane for sodium ions, blocks the conduct of nerve impulses. Prevents the appearance of painful impulses in the endings of the sensory nerves and their conduct, along nerve fibers. Benzyl nicotinate expands the surface vessels, facilitating the absorption of heparin.

    Pharmacokinetics:

    Heparin. Absorbed slightly. The connection with plasma proteins is up to 95%, the volume of distribution is 0.06 l / kg. It does not penetrate the placenta and into breast milk. Intensively captured by endothelial cells and cells of the mononuclear-macrophage system, concentrated in the liver and spleen. It is metabolized in the liver by N-desulfamidase and heparinase of platelets, which is included in the metabolism of heparin at later stages. Desulfated molecules under the influence of kidney endoglycosidase are converted into low-molecular fragments.The half-life is 1-6 hours (on the average - 1.5 hours); increases with obesity, hepatic and / or renal insufficiency; decreases with thromboembolism of the pulmonary artery, infections, malignant tumors.

    It is excreted by the kidneys, mainly in the form of inactive metabolites, and only with the introduction of high doses is it possible to excrete (up to 50%) in an unnamed form. It is not excreted by hemodialysis.

    Benzocaine for external use is practically not absorbed. It is hydrolyzed by plasma and hepatic cholinesterase to metabolites of parahaminobenzoic acid and is excreted in the urine.

    Benzyl nicotinate. Pharmacokinetics has not been studied.

    Indications:Prevention and treatment of venous thrombophlebitis, postinjection and postinfusion phlebitis.
    Contraindications:Hypersensitivity to the components of the drug, ulcerative-necrotic processes, traumatic violation of the integrity of the skin, children under 2 years.
    Carefully:Increased tendency to bleeding, thrombocytopenia.
    Pregnancy and lactation:Application during pregnancy and during breastfeeding is possible only if the potential benefit to the mother exceeds the potential,risk to the fetus and the baby.
    Dosing and Administration:

    Outwardly. The ointment is applied a thin layer on the affected area. The maximum dose of the drug is 1 g (4 cm of ointment) per 5 cm site. The ointment is applied 2-3 times daily until the inflammation disappears, on average 3 to 7 days. The possibility of a longer treatment is determined by the doctor.

    Thrombophlebitis of the extremities, phlebitis after repeated intravenous injections. Ointment is applied a thin layer on the affected area (from the calculation of 0.5-1 g (2-4 cm of ointment) to a section 3-5 cm in diameter) and carefully rub the ointment into the skin. Ointment is applied 2-3 times a day daily until the disappearance of inflammatory phenomena, on average 3 to 7 days. The possibility of a longer treatment is determined by the doctor.

    Side effects:Hyperemia of the skin, allergic reactions, contact sensitivity.
    Overdose:

    To date, the phenomenon of overdose with the use of Heparin ointment is not described. With prolonged use on large surfaces, skin hyperemia, allergic reactions, contact sensitivity are possible.

    Treatment: cancellation of the drug. If necessary, a heparin antagonist - protamine sulfate (1% solution) is used.

    Interaction:

    Do not prescribe externally simultaneously non-steroidal anti-inflammatory drugs, tetracyclines, blockers of H1-histamine receptors. Ergot alkaloids, thyroxine, tetracycline, H1-histamine receptor blockers and nicotine reduce the effect of heparin.

    With simultaneous use with non-narcotic analgesics, cholinesterase inhibitors, the action of benzocaine is enhanced. With simultaneous use with benzocaine, antibacterial activity of sulfonamides decreases.

    Special instructions:Do not apply to open wounds, mucous membranes, if there are purulent processes. It is necessary to avoid getting the drug in the eye because of the possible development of irritation. In case of accidental ingestion of ointment in the eyes, they should be washed immediately with running water.
    Effect on the ability to drive transp. cf. and fur:No information.
    Form release / dosage:Ointment for external use.
    Packaging:For 25 grams of ointments in tubes of aluminum. Each tube together with the instruction is placed in a pack of cardboard.
    Storage conditions:In the dark place at a temperature of no higher than 25 ° C. Keep out of the reach of children.
    Shelf life:

    3 years.

    Do not use after the expiration date printed on the package.

    Terms of leave from pharmacies:Without recipe
    Registration number:LS-001434
    Date of registration:27.12.2011 / 10.02.2015
    Expiration Date:Unlimited
    The owner of the registration certificate:BELMEDPREPARATY, RUP BELMEDPREPARATY, RUP Republic of Belarus
    Manufacturer: & nbsp
    BELMEDPREPARATY, RUP Republic of Belarus
    Information update date: & nbsp27.03.2017
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